Aureonitols A and B, Two New C13‐Polyketides from Chaetomium globosum, an Endophytic Fungus in Salvia miltiorrhiza

Shen, Yang; Zhao, Wen-Ting; Chen, Heng-Ye; Zhang, Lei; Liu, Ting-Kai; Chen, He‐Ping; Yang, Jian; Yang, Xiao‐Long

doi:10.1002/cbdv.201900364

Cited by 13 publications

(4 citation statements)

References 26 publications

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“…A known compound, equisetin (70, Figure 4), was purified from C. globosum of Salvia miltiorrhiza. Compound 70 displayed activity against multidrug-resistant E. faecalis, E. faecium, S. aureus, and S. epidermidis with MIC values of 3.13, 6.25, 3.13, and 6.25 µg/mL, respectively [49].…”

Section: Chaetomiummentioning

confidence: 99%

Fungal Endophytes: A Potential Source of Antibacterial Compounds

Deshmukh

Dufossé²,

Chhipa

et al. 2022

JoF

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Antibiotic resistance is becoming a burning issue due to the frequent use of antibiotics for curing common bacterial infections, indicating that we are running out of effective antibiotics. This has been more obvious during recent corona pandemics. Similarly, enhancement of antimicrobial resistance (AMR) is strengthening the pathogenicity and virulence of infectious microbes. Endophytes have shown expression of various new many bioactive compounds with significant biological activities. Specifically, in endophytic fungi, bioactive metabolites with unique skeletons have been identified which could be helpful in the prevention of increasing antimicrobial resistance. The major classes of metabolites reported include anthraquinone, sesquiterpenoid, chromone, xanthone, phenols, quinones, quinolone, piperazine, coumarins and cyclic peptides. In the present review, we reported 451 bioactive metabolites isolated from various groups of endophytic fungi from January 2015 to April 2021 along with their antibacterial profiling, chemical structures and mode of action. In addition, we also discussed various methods including epigenetic modifications, co-culture, and OSMAC to induce silent gene clusters for the production of noble bioactive compounds in endophytic fungi.

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Section: Chaetomiummentioning

confidence: 99%

Fungal Endophytes: A Potential Source of Antibacterial Compounds

Deshmukh

Dufossé²,

Chhipa

et al. 2022

JoF

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“…Seven substances, including aureonitols A (130) and B (131), chaetoviridin G (132), chaetomugilin I (123), equisetin (134), and chaetoglobosins E (135) and F (136), have been obtained from a solid fermentation culture of the endophytic fungus C. globosum derived from the aerial parts of Salvia miltiorrhiza. Amidst these compounds, 134 displays significant activities against four multidrug-resistant bacteria: E. faecalis, E. faecium, S. aureus, and S. epidermidis, with MIC values of 3-6 µg/mL [135].…”

Section: Biosynthetic Gene Clusters Of Secondary Metabolites Of Endop...mentioning

confidence: 99%

Antimicrobial Action Mechanisms of Natural Compounds Isolated from Endophytic Microorganisms

Eshboev,

Mamadalieva,

Nazarov

et al. 2024

Antibiotics

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Infectious diseases are a significant challenge to global healthcare, especially in the face of increasing antibiotic resistance. This urgent issue requires the continuous exploration and development of new antimicrobial drugs. In this regard, the secondary metabolites derived from endophytic microorganisms stand out as promising sources for finding antimicrobials. Endophytic microorganisms, residing within the internal tissues of plants, have demonstrated the capacity to produce diverse bioactive compounds with substantial pharmacological potential. Therefore, numerous new antimicrobial compounds have been isolated from endophytes, particularly from endophytic fungi and actinomycetes. However, only a limited number of these compounds have been subjected to comprehensive studies regarding their mechanisms of action against bacterial cells. Furthermore, the investigation of their effects on antibiotic-resistant bacteria and the identification of biosynthetic gene clusters responsible for synthesizing these secondary metabolites have been conducted for only a subset of these promising compounds. Through a comprehensive analysis of current research findings, this review describes the mechanisms of action of antimicrobial drugs and secondary metabolites isolated from endophytes, antibacterial activities of the natural compounds derived from endophytes against antibiotic-resistant bacteria, and biosynthetic gene clusters of endophytic fungi responsible for the synthesis of bioactive secondary metabolites.

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“…Chamiside A isolated from Chaetomium nigricolor showed effective antibacterial against S. aureus [31]. Equisetin purified from an endophytic fungus, Chaetomium globosum showed activity against several multidrug-resistant bacteria [32].…”

Section: Antibacterial Activitymentioning

confidence: 99%

Bioactive molecules from fungal endophytes and their applications in pharmaceutical industries: challenges and future scope

et al. 2023

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Medicinal plants are an important source of bioactive compounds and have been used to isolate various bioactive compounds having industrial applications. The demand for plants derived bioactive molecules is increasing gradually. However, the extensive use of these plants to extract bioactive molecules has threatened many plant species. Moreover, extracting bioactive molecules from these plants is laborious, costly, and time-consuming. So, some alternative sources and strategies are urgently needed to produce these bioactive molecules similar to that of plant origin. However, the interest in new bioactive molecules has recently shifted from plants to endophytic fungi because many fungi produce bioactive molecules similar to their host plant.Endophytic fungi live in mutualistic association within the healthy plant tissue without causing disease symptoms to the host plant. These fungi are a treasure house of novel bioactive molecules having broad pharmaceutical, industrial, and agricultural applications. The rapid increase in publications in this domain over the last three decades proves that natural product biologists and chemists are paying great attention to the natural bioactive products from endophytic fungi. Though endophytes are source of novel bioactive molecules but there is need of advanced technologies like clustered regularly interspaced short palindromic repeats and CRISPR-associated protein 9 (CRISPR-Cas9) and epigenetic modifiers to enhance the production of compounds having industrial applications. This review provides an overview of the various industrial applications of bioactive molecules produced by endophytic fungi and the rationale behind selecting specific plants for fungal endophyte isolation. Overall, this study presents the current state of knowledge and highlights the potential of endophytic fungi for developing alternative therapies for drug-resistant infections.

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Aureonitols A and B, Two New C₁₃‐Polyketides from Chaetomium globosum, an Endophytic Fungus in Salvia miltiorrhiza

Cited by 13 publications

References 26 publications

Fungal Endophytes: A Potential Source of Antibacterial Compounds

Fungal Endophytes: A Potential Source of Antibacterial Compounds

Antimicrobial Action Mechanisms of Natural Compounds Isolated from Endophytic Microorganisms

Bioactive molecules from fungal endophytes and their applications in pharmaceutical industries: challenges and future scope

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