Auric Chloride Induced Micellization on Fractal Patterned Dicationic Amphiphiles and Stabilization of Gold Nanoparticles

Abstract

The present article reports the development of sunlight-mediated rapid synthesis of bile acid derived dicationic amphiphiles, namely, dicationic cysteamine-conjugated cholic acid (DCaC), dicationic cysteamine-conjugated deoxycholic acid (DCaDC), and dicationic cysteamine-conjugated lithocholic acid (DCaLC) by adopting thiol–yne click chemistry approach. The auric chloride (AuHCl 4 ) induced micellization of amphiphiles from fractal pattern to chainlike aggregates was examined by critical micelle concentration measurements, quenching studies, field emission scanning electron microscopy, and optical microscopy techniques. The micelles thus formed act as ideal templates for the stabilization of gold nanoparticles (AuNPs) and exhibit good stability for more than 6 months. The synthesized AuNPs were characterized using UV–visible spectroscopy, high-resolution transmission electron microscopy, DLS, zeta potential, and contact angle measurements. These NPs showed high salt tolerance, and the levels were found to be 420, 460, and 580 mM for DCaC-, DCaDC-, and DCaLC-capped AuNPs, respectively.

Multifunctional Properties of Commercial Bile Salts for Advanced Materials Engineering

“…There have been interesting experiments in which cholic, deoxycholic, and lithocholic acids were modified with cysteamine and used for the manufacturing of Au NP suspensions with enhanced stability. [34] Ag and Au NPs were also prepared [35] using phenylalanineconjugated cholic acid for application in colorimetric sensors. It was found that ─OH and NH─C═O groups of phenylalanineconjugated cholic acid were involved in the reduction of ions in the precursor solutions, whereas other hydrophilic and hydrophobic groups facilitated particle dispersion.…”

“…There have been interesting experiments in which cholic, deoxycholic, and lithocholic acids were modified with cysteamine and used for the manufacturing of Au NP suspensions with enhanced stability. [ 34 ]…”

Synthesis ofN‐Acetylcysteine Conjugated Cholic Acid Stabilized Gold and Silver Nanoparticles: Evaluation of Their Catalytic Activity and Toxicity Assessment

“…[31] Besides they reported bile acid derived facially amphiphilic thiols stabilized Ag and Au NPs. [32] Clarke et al demonstrated in-vitro antibacterial activity of unconjugated and conjugated bile salts on Staphylococcus aureus. [33] Camilleri et al reported antimicrobial activity of new bile acid-based gemini surfactants where it and they showed increased antibacterial activity as increase in the number of primary amino groups.…”