2023
DOI: 10.3390/cells12202434
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Aurora Kinase A Regulates Cell Transitions in Glucocorticoid-Induced Bone Loss

Xiaojing Qiao,
Yang Yang,
Yan Zhao
et al.

Abstract: Glucocorticoid-induced bone loss is a severe and toxic effect of long-term therapy with glucocorticoids, which are currently prescribed for millions of people worldwide. Previous studies have uncovered that glucocorticoids reciprocally converted osteoblast lineage cells into endothelial-like cells to cause bone loss and showed that the modulations of Foxc2 and Osterix were the causative factors that drove this harmful transition of osteoblast lineage cells. Here, we find that the inhibition of aurora kinase A … Show more

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