Australia Antigen, Hepatitis Virus and Downs Syndrome*

Blumberg, Baruch S.; Gerstley, Betty Jane S.; Sutnick, Alton I.; Millman, Irving; London, W. Thomas

doi:10.1111/j.1749-6632.1970.tb39358.x

Cited by 35 publications

(5 citation statements)

References 24 publications

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“…*Au(0) = patients without Australia antigen or antibody. consistent with our earlier observations that Au(1) is more common in males than in females in 22 of 23 populations studied (London et al, 1969;Sutnick et al, 1968;Blumberg et al, 1970b;Blumberg et al, 1972). The higher frequency of antibody in females has not been observed previously.…”

Section: Discussionsupporting

confidence: 93%

“…Au(1) is more frequent in males (14-3%) than in females (6 4%) (Table I). This difference is not statistically significant (x2 = 1-972, P >0 10), but it is consistent with findings in other healthy and disease populations (London, Sutnick, and Blumberg, 1969;Sutnick et al, 1968;Blumberg et al, 1970b;Blumberg et al, 1972). Antibody is more frequent in females (30 0%) than in males (22.9%), but this difference is also not significant (x2 = 0-26, P >0 50).…”

Section: Resultssupporting

confidence: 80%

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Australia Antigen and Antibody in Transfused Children with Thalassaemia

Vierucci¹,

London²,

Blumberg³

et al. 1972

Archives of Disease in Childhood

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Section: Discussionsupporting

confidence: 93%

Section: Resultssupporting

confidence: 80%

Australia Antigen and Antibody in Transfused Children with Thalassaemia

Vierucci¹,

London²,

Blumberg³

et al. 1972

Archives of Disease in Childhood

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“…similar functional defects or anomalies can be found in different (aneuploid) aberrations" [ 1121. Similarly, lymphocyte abnormalities have been described [ 109,1141, especially a diminished cellular immune response [ 115,1161. Significant abnormalities in DS subjects of B cells, T cells, and cells bearing receptors for the Fc portion of IgG were reported [117].…”

mentioning

confidence: 98%

Down syndrome—a disruption of homeostasis

1983

Am. J. Med. Genet.

273

139

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A major question in human genetics concerns the relationship between the extra chromosome material in the Down syndrome (DS) and its effects. It is suggested here that a generalized disruption of evolved genetic balance in cells of affected individuals leads to decreased developmental and physiological buffering against genetic and environmental forces. Examples of consequences in DS of this model of disruption of homeostasis are presented: i) increased variance for metric traits, ii) amplified instability of developmental pathways, iii) reduced precision of physiological homeostatic controls, and iv) generalized increased morbidity. Evolution has selected for interacting systems. When this evolved balance is disrupted, as in autosomal aneuploidy, the organism is generally disrupted. The model emphasizes the role of environment in producing much of the DS phenotype. Traits less buffered than others in the general population are the ones most disturbed in DS and account for much of the DS phenotype.

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“…when compared with their non-Down's institutionalised peers (Blumberg & Alter 1965, Blumberg et al 1967, Sutnick et al 1968). Blumberg et al (1970) have suggested that the Down's patients were either uniquely susceptible to the virus or retained the agent chronically due to an inherited immunologic defect possibly involving impaired lymphocyte function. Blumberg et al (1970) have suggested that the Down's patients were either uniquely susceptible to the virus or retained the agent chronically due to an inherited immunologic defect possibly involving impaired lymphocyte function.…”

mentioning

confidence: 99%

“…These findings have been confirmed by a number of studies (Krugman & Giles 1970, Skinhoj et al 1971, Chance 1972, Hollinger et al 1972, Boughton & Hawkes 1973, Rundle et al 1975). Blumberg et al (1970) have suggested that the Down's patients were either uniquely susceptible to the virus or retained the agent chronically due to an inherited immunologic defect possibly involving impaired lymphocyte function.…”

mentioning

confidence: 99%

Hepatitis associated antigen and the ABO locus in Down's syndrome

Rundle¹,

Atkin²,

Sudell³

1975

Clinical Genetics

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The recent observation by Arndt-Hansen et al. (1974) of increased frequency of blood group A over group 0 in blood donors positive for the hepatitis associated antigen has been investigated in Down's syndrome, in order to establish if this could account for the increased frequency of the antigen in that syndrome.Seventy-one of 227 subjects with Down's syndrome (31.3 %) were found to be positive for the antigen by haemagglutination, and comparison of these with the HAA-subjects failed to reveal any differences in the ABO blood groups.

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Australia Antigen, Hepatitis Virus and Downs Syndrome*

Cited by 35 publications

References 24 publications

Australia Antigen and Antibody in Transfused Children with Thalassaemia

Australia Antigen and Antibody in Transfused Children with Thalassaemia

Down syndrome—a disruption of homeostasis

Hepatitis associated antigen and the ABO locus in Down's syndrome

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