Authentication of Antibiotics Using Portable Near-Infrared Spectroscopy and Multivariate Data Analysis

Assi, Sulaf; Arafat, Basel; Lawson-Wood, Kathryn; Robertson, I.D.

doi:10.1177/0003702820958081

Cited by 20 publications

(10 citation statements)

References 30 publications

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“…Intensity variations in spectra obtained from each tablet category were minimized by employing the multiplicative scatter correction (MSC) technique. 36,37 MSC is a commonly used normalization technique that adjusts individual spectra to better match a reference, which is typically the data set mean, by adjusting offsets and scaling. 38 Measurement specicity was enhanced by calculating the second derivatives of spectra prior to applying PCA.…”

Section: Resultsmentioning

confidence: 99%

Discrimination of commercial ibuprofen tablets by using a button sample holder and mid-infrared spectroscopy

Singh

White

2022

Anal. Methods

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Section: Resultsmentioning

confidence: 99%

Discrimination of commercial ibuprofen tablets by using a button sample holder and mid-infrared spectroscopy

Singh

White

2022

Anal. Methods

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“…While both used acetonitrile detection of the antibiotic from soil prior to spectroscopical analysis, our work represents the detection directly in soil samples which makes it easier and practical to use if FTIR is coupled to a hand held device. Assi et al ( 2021 ) validated the use of portable near infra-red spectroscopy for detection of several groups of antibiotics in their pure form. The results obtained showed an increase in transmittance peaks that were proportional to the azithromycin concentrations in the soil sample.…”

Section: Discussionmentioning

confidence: 99%

Biodegradation of COVID19 antibiotic; azithromycin and its impact on soil microbial community in the presence of phenolic waste and with temperature variation

Ibrahim

El-Bialy

Gomaa

2023

World J Microbiol Biotechnol

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The increase in using antibiotics, especially Azithromycin have increased steadily since the beginning of COVID19 pandemic. This increase has led to its presence in water systems which consequently led to its presence upon using this water for irrigation. The aim of the present work is to study the impact of irrigation using Azithromycin containing water on soil microbial community and its catabolic activity in the presence of phenolic wastes as compost. Wild berry, red grapes, pomegranate, and spent tea waste were added to soil and the degradation was monitored after 5 and 7 days at ambient and high temperatures. The results obtained show that at 30 °C, soil microbial community collectively was able to degrade Azithromycin, while at 40 °C, addition of spent tea as compost was needed to reach higher degradation. To ensure that the degradation was biotic and depended on degradation by indigenous microflora, a 25 kGy irradiation dose was used to kill the microorganisms in the soil and this was used as negative control. The residual antibiotic was assayed using UV spectroscopy and High Performance Liquid Chromatography (HPLC). Indication of Azithromycin presence was studied using Fourier Transform Infrared Spectroscopy (FTIR) peaks and the same pattern was obtained using the 3 used detection methods, the ability to assign the peaks even in the presence of soil and not to have any overlaps, gives the chance to study this result in depth to prepare IR based sensor for quick sensing of antibiotic in environmental samples.

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“…Miniaturization of infrared spectrometers will lead to their wider use in consumer electronics—such as mobile phones enabling food control, the detection of hazardous chemicals and wearable electronics. Besides the highly interesting infrared fingerprint and functional group regions (2.5–20.0 μm), a Fourier-transform near-infrared spectrometer operating between 0.76 and 2.50 μm can be used for the counterfeit detection of medical drugs 1 , or the detection of Earth’s greenhouse gases such as methane and CO 2 (ref. 2 ); however, higher sensitivity and specificity are usually achieved in the mid-wave infrared region.…”

Section: Mainmentioning

confidence: 99%

Integrated photodetectors for compact Fourier-transform waveguide spectrometers

et al. 2022

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Extreme miniaturization of infrared spectrometers is critical for their integration into next-generation consumer electronics, wearables and ultrasmall satellites. In the infrared, there is a necessary compromise between high spectral bandwidth and high spectral resolution when miniaturizing dispersive elements, narrow band-pass filters and reconstructive spectrometers. Fourier-transform spectrometers are known for their large bandwidth and high spectral resolution in the infrared; however, they have not been fully miniaturized. Waveguide-based Fourier-transform spectrometers offer a low device footprint, but rely on an external imaging sensor such as bulky and expensive InGaAs cameras. Here we demonstrate a proof-of-concept miniaturized Fourier-transform waveguide spectrometer that incorporates a subwavelength and complementary-metal–oxide–semiconductor-compatible colloidal quantum dot photodetector as a light sensor. The resulting spectrometer exhibits a large spectral bandwidth and moderate spectral resolution of 50 cm−1 at a total active spectrometer volume below 100 μm × 100 μm × 100 μm. This ultracompact spectrometer design allows the integration of optical/analytical measurement instruments into consumer electronics and space devices.

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Authentication of Antibiotics Using Portable Near-Infrared Spectroscopy and Multivariate Data Analysis

Cited by 20 publications

References 30 publications

Discrimination of commercial ibuprofen tablets by using a button sample holder and mid-infrared spectroscopy

Discrimination of commercial ibuprofen tablets by using a button sample holder and mid-infrared spectroscopy

Biodegradation of COVID19 antibiotic; azithromycin and its impact on soil microbial community in the presence of phenolic waste and with temperature variation

Integrated photodetectors for compact Fourier-transform waveguide spectrometers

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