Author Correction: Cancer LncRNA Census reveals evidence for deep functional conservation of long noncoding RNAs in tumorigenesis

Carlevaro-Fita, Joana; Lanzós, Andrés; Feuerbach, Lars; Hong, Chen; Mas-Ponte, David; Pedersen, Jakob Skou; Johnson, Rory

doi:10.1038/s42003-022-03769-z

Cited by 3 publications

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“…Apart from a few well-known lncRNAs, the landscape of cancer lncRNAs is far from complete. The diverse functional repertoire of lncRNAs in cancer can be explored through (1) their function as driver genes, resulting from early mutations that are positively selected during tumorigenesis, or (2) as downstream genes, resulting from non-genetic changes in their expression, localization, or molecular interactions [108]. Although both categories contribute to cancer phenotypes, most efforts to discover cancer lncRNAs only take advantage of differential expression approaches.…”

Section: Describing the Novel Lncrnas Drivers In Cancer Through Multi...mentioning

confidence: 99%

“…More recently, to enhance the discovery of cancer-related lncRNAs and gain insight into their biology, the Cancer lncRNA Census (CLC) was presented as a tool to provide functional or genetic evidence of lncRNAs roles in cancer by integrating genomic and transcriptomic data associated with cancer in different mammalian species [108]. To date, it is not completely clear whether mutated lncRNAs can drive tumorigenesis and whether such altered functions could be conserved during evolution.…”

Section: Describing the Novel Lncrnas Drivers In Cancer Through Multi...mentioning

confidence: 99%

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Multi-Omics Mining of lncRNAs with Biological and Clinical Relevance in Cancer

Salido-Guadarrama,

Romero-Cordoba,

Rueda-Zarazua

2023

IJMS

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In this review, we provide a general overview of the current panorama of mining strategies for multi-omics data to investigate lncRNAs with an actual or potential role as biological markers in cancer. Several multi-omics studies focusing on lncRNAs have been performed in the past with varying scopes. Nevertheless, many questions remain regarding the pragmatic application of different molecular technologies and bioinformatics algorithms for mining multi-omics data. Here, we attempt to address some of the less discussed aspects of the practical applications using different study designs for incorporating bioinformatics and statistical analyses of multi-omics data. Finally, we discuss the potential improvements and new paradigms aimed at unraveling the role and utility of lncRNAs in cancer and their potential use as molecular markers for cancer diagnosis and outcome prediction.

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Section: Describing the Novel Lncrnas Drivers In Cancer Through Multi...mentioning

confidence: 99%

Section: Describing the Novel Lncrnas Drivers In Cancer Through Multi...mentioning

confidence: 99%

Multi-Omics Mining of lncRNAs with Biological and Clinical Relevance in Cancer

Salido-Guadarrama,

Romero-Cordoba,

Rueda-Zarazua

2023

IJMS

View full text Add to dashboard Cite

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Expression of long noncoding RNA MEG3 and microRNA-302b-3p in colon cancer: Correlation with clinical stage and value in predicing prognosis after surgical treatment

Sun,

Yue

2023

WCJD

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Multi-Omics Mining of LNC-RNAs With Biological and Clinical Relevance in Cancer

Salido-Guadarrama,

Romero-Cordoba,

Rueda-Zarazua

2023

Preprint

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In this review, we will cover a general overview of the current panorama on lncRNAs with an actual or potential role as biological markers in cancer. We will discuss examples of multi-omics approaches that integrates information on somatic aberrations, gene expression and epigenomics, with the scope of providing a more comprehensive view of the functional impact of lncRNA profiles and how these paradigm can be exploited for the discovery and selection of lncRNAs with a functional role and their use as variables informing on progression and prognostic and help guiding the selection of therapeutic strategies for cancers. Finally, we propose a perspective for future evolution of the study of lncRNAs and the discovery of their functional and harnessing their potential to assist in clinical management of malignancies.

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Author Correction: Cancer LncRNA Census reveals evidence for deep functional conservation of long noncoding RNAs in tumorigenesis

Cited by 3 publications

References 0 publications

Multi-Omics Mining of lncRNAs with Biological and Clinical Relevance in Cancer

Multi-Omics Mining of lncRNAs with Biological and Clinical Relevance in Cancer

Expression of long noncoding RNA MEG3 and microRNA-302b-3p in colon cancer: Correlation with clinical stage and value in predicing prognosis after surgical treatment

Multi-Omics Mining of LNC-RNAs With Biological and Clinical Relevance in Cancer

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