Author Correction: Epigenetic stress responses induce muscle stem-cell ageing by Hoxa9 developmental signals

Schwörer, Simon; F, Becker; Feller, Christian; Baig, Ali H.; Köber, Ute; Henze, Henriette; Kraus, Johann M.; Xin, Baoping; Lechel, André; Lipka, Daniel B.; Varghese, Christy S.; Schmidt, Mario; Rohs, Remo; Aebersold, Ruedi; Medina, Kay L.; Kestler, Hans A.; Neri, Francesco; Tümpel, Stefan; Rudolph, K. Lenhard

doi:10.1038/s41586-019-1455-1

Cited by 2 publications

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“…Hoxd8 belongs to the Hox gene family, an important regulator family that functions in embryogenesis (Mcginnis and Krumlauf, 1992). Recent studies suggested that reactivation of this developmentally critical gene family played an unexpected role during aging (Schwörer et al, 2016). For example, Hoxa9 was discovered to be reactivated in aged FIGURE 5 | Transcription factor (TF) HOXD8 is a new senescence regulator in mouse embryonic fibroblasts (MEFs).…”

Section: Discussionmentioning

confidence: 99%

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Single-Cell Transcriptome Analysis Reveals Six Subpopulations Reflecting Distinct Cellular Fates in Senescent Mouse Embryonic Fibroblasts

et al. 2020

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Replicative senescence is a hallmark of aging, which also contributes to individual aging. Mouse embryonic fibroblasts (MEFs) provide a convenient replicative senescence model. However, the heterogeneity of single MEFs during cellular senescence has remained unclear. Here, we conducted single-cell RNA sequencing on senescent MEFs. Principal component analysis showed obvious heterogeneity among these MEFs such that they could be divided into six subpopulations. Three types of gene expression analysis revealed distinct expression features of these six subpopulations. Trajectory analysis revealed three distinct lineages during MEF senescence. In the main lineage, some senescence-associated secretory phenotypes were upregulated in a subset of cells from senescent clusters, which could not be distinguished in a previous bulk study. In the other two lineages, a possibility of escape from cell cycle arrest and coupling between translation-related genes and ATP synthesis-related genes were also discovered. Additionally, we found co-expression of transcription factor HOXD8 coding gene and its potential target genes in the main lineage. Overexpression of Hoxd8 led to senescence-associated phenotypes, suggesting HOXD8 is a new regulator of MEF senescence. Together, our single-cell sequencing on senescent MEFs largely expanded the knowledge of a basic cell model for aging research.

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Section: Discussionmentioning

confidence: 99%

“…* , * * , and * * * represent p-values less than 0.05, 0.01, and 0.001 by t-test, respectively. individuals and impaired the function of the muscle stem cell (Schwörer et al, 2016). As for Hoxd8, it has been reported to regulate the cell cycle and oncogenesis in several carcinomas (Liu et al, 2016;Mansour and Senga, 2017).…”

Section: Discussionmentioning

confidence: 99%

Single-Cell Transcriptome Analysis Reveals Six Subpopulations Reflecting Distinct Cellular Fates in Senescent Mouse Embryonic Fibroblasts

et al. 2020

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“…Similar research also confirmed that HOXA9 cooperated with STAT5 locates in the same genomic loci resulting in an increased JAK/STAT signaling [ 51 ]. Related evidence also showed that HOXA9 was induced in aged mice, which in turn activates several developmental pathways including Wnt, TGFβ, and JAK/STAT signaling pathway [ 52 ]. While the exact mechanism on HOXA9 associated with JAK/STAT signaling pathway in solid tumors is further needed.…”

Section: Jak/stat Signaling Pathwaymentioning

confidence: 99%

Role of HOXA9 in solid tumors: mechanistic insights and therapeutic potential

et al. 2022

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HOXA9 functioning as a transcription factor is one of the members of HOX gene family, which governs multiple cellular activities by facilitating cellular signal transduction. In addition to be a driver in AML which has been widely studied, the role of HOXA9 in solid tumor progression has also received increasing attention in recent years, where the aberrant expression of HOXA9 is closely associated with the prognosis of patient. This review details the signaling pathways, binding partners, post-transcriptional regulation of HOXA9, and possible inhibitors of HOXA9 in solid tumors, which provides a reference basis for further study on the role of HOXA9 in solid tumors.

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Author Correction: Epigenetic stress responses induce muscle stem-cell ageing by Hoxa9 developmental signals

Cited by 2 publications

References 0 publications

Single-Cell Transcriptome Analysis Reveals Six Subpopulations Reflecting Distinct Cellular Fates in Senescent Mouse Embryonic Fibroblasts

Single-Cell Transcriptome Analysis Reveals Six Subpopulations Reflecting Distinct Cellular Fates in Senescent Mouse Embryonic Fibroblasts

Role of HOXA9 in solid tumors: mechanistic insights and therapeutic potential

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