2022
DOI: 10.1038/s41586-022-05578-0
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Author Correction: Failure of human rhombic lip differentiation underlies medulloblastoma formation

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Cited by 4 publications
(3 citation statements)
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“…We could speculate that OTX2 down-regulation may determine the activation of the pathways of cerebellar differentiation in MB cells. These data have great importance because the use of the combination of AA7.1, as specific targets of Prune-1, and SP-2577 molecules might also result at the interplay between Gr3 and Gr4 MB, with OTX-2 being an important component of Gr4 MB predisposition too [16].…”
Section: Discussionmentioning
confidence: 99%
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“…We could speculate that OTX2 down-regulation may determine the activation of the pathways of cerebellar differentiation in MB cells. These data have great importance because the use of the combination of AA7.1, as specific targets of Prune-1, and SP-2577 molecules might also result at the interplay between Gr3 and Gr4 MB, with OTX-2 being an important component of Gr4 MB predisposition too [16].…”
Section: Discussionmentioning
confidence: 99%
“…In Gr3, we found that Prune-1 enhances the canonical TGF-β pathway followed by OTX2 and SNAIL up-regulation and PTEN down-regulation [15]. Furthermore, OTX2 maintains rhombic lip (RL) identity by inhibiting the CBFA complex until the cells exit the RL and differentiate [16]. The overexpression of OTX2 results in failed RL differentiation.…”
Section: Introductionmentioning
confidence: 99%
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