Author Correction: Hepatitis B, Hepatitis C, tuberculosis and sexually-transmitted infections among HIV positive patients in Kazakhstan

Mukhatayeva, Ainur; Mustafa, Aidana; Dzissyuk, Natalya; Bayserkin, Bauyrzhan; Vermund, Sten H.; Ali, Syed

doi:10.1038/s41598-021-97673-x

Cited by 3 publications

(3 citation statements)

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“…Existing studies have been conducted covering only limited disperse geographic regions. [7][8][9][10][11] The digitalisation of the national healthcare system and the establishment of the UNEHS over the last decade make it feasible to conduct nationwide large-scale epidemiological studies in Kazakhstan. [12][13][14] Therefore, the objective of this in-depth epidemiological study is to estimate the incidence and mortality rates of TB in Kazakhstan, using large-scale administrative health data records between 2014 and 2019, available in the UNEHS database.…”

Section: Open Accessmentioning

confidence: 99%

“…Regardless of the public health impact of TB, there are limited comprehensive reports and publications on the epidemiology of TB in Kazakhstan. Existing studies have been conducted covering only limited disperse geographic regions 7–11. The digitalisation of the national healthcare system and the establishment of the UNEHS over the last decade make it feasible to conduct nationwide large-scale epidemiological studies in Kazakhstan 12–14…”

Section: Introductionmentioning

confidence: 99%

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Epidemiology of tuberculosis in Kazakhstan: data from the Unified National Electronic Healthcare System 2014–2019

Sakko,

Madikenova,

Kim

et al. 2023

BMJ Open

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ObjectivesThis study aims to estimate tuberculosis (TB) incidence, mortality rates and survival HRs in Kazakhstan, using large-scale administrative health data records during 2014–2019.DesignA retrospective cohort study.SettingsData for patients with TB in Kazakhstan during 2014–2019, reported in the Unified National Electronic Healthcare System.ParticipantsPatients with TB in Kazakhstan (ICD-10 (The International Classification of Diseases, 10th revision) codes: A15–A19).Outcome measuresDemographic factors, diagnoses and comorbidities were analysed using descriptive, bivariate and multivariable statistical analyses. TB incidence and mortality rates were calculated, and Cox regression and Kaplan-Meier survival analysis were performed to assess risk factors for survival rates.ResultsOf the 149 122 patients with TB, 91 437 (61%) were males, and 139 931 (94%) had respiratory TB. From 2014 to 2019, TB incidence declined from 227 to 15.2 per 100 000 individuals, while all-cause mortality increased from 8.4 to 15.2 per 100 000. Age-specific TB incidence was lowest for 0–10 years of age and highest for 20 years of age. Being older, man, urban residence versus rural, retired versus employed, having HIV and having diabetes versus no comorbidities were associated with lower survival rates.ConclusionTo date, this is the largest TB published study for Kazakhstan, characterising TB incidence and mortality trends by demographic factors, and risk factors for survival rates. The findings highlight the need for targeted interventions to address the growing burden of TB, particularly among older adults, men, urban residents and those with HIV and diabetes. The study underscores the importance of using administrative health data to inform policy and health system responses to TB in Kazakhstan.

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Section: Open Accessmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Epidemiology of tuberculosis in Kazakhstan: data from the Unified National Electronic Healthcare System 2014–2019

Sakko,

Madikenova,

Kim

et al. 2023

BMJ Open

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“…14 Currently, all available data is either from single-center analysis or from studies performed within high-risk populations. [15][16][17] For example, two major Liver transplant centers in Kazakhstan performed a little over 200 cases of orthotopic liver transplants with half of the referrals due to viral hepatitis B, C and D. Among 131 liver transplantation cases at Syzganov Center, Almaty, 47 cases were due to HBV and HBV+HDV infection, and 12 cases -due to HCVinduced liver cirrhosis. 18 Another study from the National Oncology Center in Nur-Sultan reported 30 patients with liver cirrhosis due to HBV and HBV+HDV infections, and four cases of HCV infection among 64 transplantations carried out at the center.…”

Section: Introductionmentioning

confidence: 99%

Epidemiological Characteristics of Chronic Viral Hepatitis in Kazakhstan: Data from Unified Nationwide Electronic Healthcare System 2014–2019

Ashimkhanova¹,

Syssoyev²,

Gusmanov³

et al. 2022

IDR

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Background: Viral hepatitis is the leading cause of hepatic cirrhosis and liver-related mortality, yet there are no countrywide epidemiological studies available to date in Kazakhstan. The aim of the study was to perform an estimation of mortality, prevalence and incidence of Hepatitis B and C infections and liver-related complications. Methods: Using centralized healthcare data from the Unified National Electronic Health System (UNEHS) for the period 2014-2019, a total of 82,700 registered patients with chronic viral hepatitis B (HBV), C (HCV) and D (HDV) have been extracted based on ICD −10 codes. Crude rates of incidence, prevalence and mortality, as well as age-, sex-and year-specific rates of incidence and mortality per 100,000 population were estimated. Unadjusted and adjusted hazard ratios were estimated using Cox proportional hazards regression modeling. Results: For the total number of 82,700 patients, 56.6% were represented by chronic HCV infection and 43.4% by HBV infection. The prevalence of coinfection was 10% for HBV+HDV and 3.5% for HBV+HCV. Both HBV and HCV were more prevalent among female patients (56%) and among Kazakh ethnic group (64.8%). Males with HBV had a higher probability of death than females; this trend was stronger among male patients with HCV. Russian ethnic groups infected with HBV had a higher risk of death compared to Kazakh and other ethnic groups. Whereas in HCV-infected patients, Russian ethnic group and other ethnic group had similar risk for death, but higher compared to Kazakhs. Conclusion: During the 2014-2019 period, prevalence, incidence and mortality from chronic HBV and HCV infections increased. Despite the disproportionately higher infection rate among females with chronic viral hepatitis, all-cause mortality was more than twofold higher among males. Higher death rates in Russian ethnic group compared to other ethnicities need to be evaluated in further studies for other confounding factors and associated comorbidities in this group.

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Improved Algorithm-Based Magnetic Resonance Images Combined with Computed Tomography in the Diagnosis of Acquired Immune Deficiency Syndrome Combined with Spinal Tuberculosis

Jiang

Shi

et al. 2022

Scientific Programming

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This study aimed to analyze the diagnostic value of magnetic resonance imaging (MRI) combined with computed tomography (CT) based on the improved algorithm for acquired immune deficiency syndrome (AIDS) combined with spinal tuberculosis, so as to provide an effective reference theory for the clinical application of imaging diagnosis. The ResNet and Inception network structure were combined to form an improved convolutional neural grid classification (CNGC) algorithm. The improved algorithm was applied to AIDS patients with spinal tuberculosis to evaluate its diagnostic effect and value. 50 patients with AIDS and spinal tuberculosis and 50 patients with spinal tumors were selected for MRI and CT scans. The results showed that the accuracy, specificity, and sensitivity of the improved ResNet-Inception algorithm were much higher than those of the ResNet18 and GoogLeNet algorithms. In addition, compared with the training losses of ResNet18 and GoogLeNet algorithms that converged after 700 times, the ResNet-Inception algorithm only required 350 times to achieve convergence. Based on the improved ResNet-Inception algorithm, the false positive rate (FPR) of AIDS combined with spinal tuberculosis in imaging examinations was about 4%, which was greatly lower than that of the other two traditional algorithms ( P < 0.05 ). It can be seen that the improved ResNet-Inception algorithm was more valuable than traditional algorithms for MRI combined with CT in the diagnosis of AIDS combined with spinal tuberculosis and showed great clinical value for the diagnosis of the disease and the differential diagnosis of spinal tumors.

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Author Correction: Hepatitis B, Hepatitis C, tuberculosis and sexually-transmitted infections among HIV positive patients in Kazakhstan

Cited by 3 publications

References 0 publications

Epidemiology of tuberculosis in Kazakhstan: data from the Unified National Electronic Healthcare System 2014–2019

Epidemiology of tuberculosis in Kazakhstan: data from the Unified National Electronic Healthcare System 2014–2019

Epidemiological Characteristics of Chronic Viral Hepatitis in Kazakhstan: Data from Unified Nationwide Electronic Healthcare System 2014–2019

Improved Algorithm-Based Magnetic Resonance Images Combined with Computed Tomography in the Diagnosis of Acquired Immune Deficiency Syndrome Combined with Spinal Tuberculosis

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