Author Correction: Mir-21 Mediates the Inhibitory Effect of Ang (1–7) on AngII-induced NLRP3 Inflammasome Activation by Targeting Spry1 in lung fibroblasts

Sun, Nana; Yu, Chang; Pan, Miao; Zhang, Yue; Yang, Qian; Zheng, Ze Mao; Meng, Ying

doi:10.1038/s41598-020-78308-z

Cited by 3 publications

(2 citation statements)

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“…37 A recent study also demonstrated that miR-21-5p targeting SPRY1 played a vital role in lung fibroblasts. 38 In this study, dual-luciferase assay results showed that miR-21-5p indeed directly targets SPRY1 in RAW 264.7 cells. The overexpression of SPRY1 enhanced the protective effect of the miR-21-5p inhibitor on inflammation responses.…”

Section: Discussionmentioning

confidence: 53%

Mogroside V alleviates inflammation response by modulating miR-21-5P/SPRY1 axis

Han,

Liu,

Liu

et al. 2024

Food Funct.

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Section: Discussionmentioning

confidence: 53%

Mogroside V alleviates inflammation response by modulating miR-21-5P/SPRY1 axis

Han,

Liu,

Liu

et al. 2024

Food Funct.

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“…ACE-2 down-regulation leads to an increased activation of NF-κB through the angiotensin receptor type 1 (AT1R) and mediated by protein kinases: mitogen-activated protein-kinase/extracellular signal axis-regulated-kinase (MAPK/ERK). This represents the mechanism of first-occurring NLR family pyrin domain containing 3 (NLRP3) inflammasome activation during SARS-CoV-2 infection [30,31].…”

Section: Sars-cov-2 Infection In Children and Immune Functionmentioning

confidence: 99%

Immunonutrition and SARS-CoV-2 Infection in Children with Obesity

et al. 2022

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Since the beginning of the SARS-CoV-2 pandemic, there has been much discussion about the role of diet and antiviral immunity in the context of SARS-CoV-2 infection. Intake levels of vitamins D, C, B12, and iron have been demonstrated to be correlated with lower COVID-19 incidence and mortality. Obesity has been demonstrated to be an independent risk for the severity of COVID-19 infection in adults and also in children. This may be due to different mechanisms, mainly including the gut dysbiosis status observed in obese children. Moreover, the existence of a gut–lung axis added new knowledge to on the potential mechanisms by which diet and dietary substances may affect immune function. The aim of this narrative review is to address the intricate inter-relationship between COVID-19, immune function, and obesity-related inflammation and to describe the role of nutrients and dietary patterns in enhancing the immune system. Two ways to fight against COVID-19 disease exist: one with an antiviral response through immune system boosting and another with antioxidants with an anti-inflammatory effect. In the current pandemic situation, the intake of a varied and balanced diet, rich in micronutrients and bioactive compounds including fibers, should be recommended. However, clinical studies conducted on children affected by SARS-CoV-2 infection and comorbidity are warranted.

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