Author Correction: Structures of a deltacoronavirus spike protein bound to porcine and human receptors

Ji, Weiwei; Peng, Qi; Fang, Xueqiong; Li, Zehou; Li, Yaxin; Xu, Cunfa; Zhao, Shuqing; Li, Jizong; Chen, Rong; Mo, Guoxiang; Wei, Zhanyong; Xu, Ying; Li, Bin; Zhang, Shuijun

doi:10.1038/s41467-023-40128-w

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“… Schematic representation of the APN protein with the different domains and virus–binding regions indicated. Virus–binding regions of TGEV, PEDV, and PDCoV are indicated, as previously reported [ 23 , 26 , 41 , 42 ]. The porcine APN amino acid sequence comparison with human, monkey, mouse, canine, bovine and chicken shows a homology range from 63.3% to 83.3%.…”

Section: Figurementioning

confidence: 88%

“…PEDV is more susceptible to Vero-E6 and BHK-21 cells at a higher level than that of TGEV and PDCoV. The growth potential of coronavirus in a variety of cells correlated with the utilization of its receptor molecule [ 37 , 42 ]. Most known coronaviruses become infective in cells when their functional receptor molecule is expressed by transfection with a plasmid encoding the receptor molecule [ 37 ].…”

Section: Discussionmentioning

confidence: 99%

“…The chicken APN had a 73.8% amino acid identity to pAPN in domain II, which is the lowest among different species (Figure 8). [23,26,41,42]. The porcine APN amino acid sequence comparison with human, monkey, mouse, canine, bovine and chicken shows a homology range from 63.3% to 83.3%.…”

Section: Vero E6 and Bhk-21 Cells Are Both More Susceptible To Pedvmentioning

confidence: 99%

“…The porcine APN amino acid sequence comparison with human, monkey, mouse, canine, bovine and chicken shows a homology range from 63.3% to 83.3%. When [23,26,41,42]. The porcine APN amino acid sequence comparison with human, monkey, mouse, canine, bovine and chicken shows a homology range from 63.3% to 83.3%.…”

Section: Vero E6 and Bhk-21 Cells Are Both More Susceptible To Pedvmentioning

confidence: 99%

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Different Infectivity of Swine Enteric Coronaviruses in Cells of Various Species

Li,

Chen,

et al. 2024

Pathogens

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Swine enteric coronaviruses (SECoVs), including porcine deltacoronavirus (PDCoV), transmissible gastroenteritis virus (TGEV), porcine epidemic diarrhea virus (PEDV), and swine acute diarrhea syndrome coronavirus (SADS-CoV), have caused high mortality in piglets and, therefore, pose serious threats to the pork industry. Coronaviruses exhibit a trend of interspecies transmission, and understanding the host range of SECoVs is crucial for improving our ability to predict and control future epidemics. Here, the replication of PDCoV, TGEV, and PEDV in cells from different host species was compared by measuring viral genomic RNA transcription and protein synthesis. We demonstrated that PDCoV had a higher efficiency in infecting human lung adenocarcinoma cells (A549), Madin–Darby bovine kidney cells (MDBK), Madin–Darby canine kidney cells (MDCK), and chicken embryonic fibroblast cells (DF-1) than PEDV and TGEV. Moreover, trypsin can enhance the infectivity of PDCoV to MDCK cells that are nonsusceptible to TGEV. Additionally, structural analyses of the receptor ectodomain indicate that PDCoV S1 engages Aminopeptidase N (APN) via domain II, which is highly conserved among animal species of different vertebrates. Our findings provide a basis for understanding the interspecies transmission potential of these three porcine coronaviruses.

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Section: Figurementioning

confidence: 88%

Section: Discussionmentioning

confidence: 99%

Section: Vero E6 and Bhk-21 Cells Are Both More Susceptible To Pedvmentioning

confidence: 99%

Section: Vero E6 and Bhk-21 Cells Are Both More Susceptible To Pedvmentioning

confidence: 99%

See 2 more Smart Citations

Different Infectivity of Swine Enteric Coronaviruses in Cells of Various Species

Li,

Chen,

et al. 2024

Pathogens

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show abstract

Author Correction: Structures of a deltacoronavirus spike protein bound to porcine and human receptors

Cited by 1 publication

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Different Infectivity of Swine Enteric Coronaviruses in Cells of Various Species

Different Infectivity of Swine Enteric Coronaviruses in Cells of Various Species

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