Author Correction: The genetic legacy of continental scale admixture in Indian Austroasiatic speakers

Tätte, Kai; Pagani, Luca; Pathak, Ajai Kumar; Kõks, Sulev; Duy, Binh Ho; Ho, Xuan Dung; Sultana, Gazi Nurun Nahar; Sharif, Mohd Istiaq; Asaduzzaman, Md; Behar, Doron M.; Hadid, Yarin; Villems, Richard; Chaubey, Gyaneshwer; Kivisild, Toomas; Metspalu, Mait

doi:10.1038/s41598-019-42195-w

Cited by 2 publications

(1 citation statement)

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“…The admixture between local Indians and incoming Southeast Asians took place ~2000-3800 years ago giving rise to the AAA ancestry. Notably, the Indian population(s) with whom the incoming Southeast Asians mingled were AASI related with little to no West Eurasian ancestry fraction [47]. Finally, it has been showed that the Tibeto-Burmans (ATBs) derived their ancestry through admixture with low-altitude East Asians who migrated from China and likely across Northern India or Myanmar [48] leading to the high genomic proximity between Indians of ATB ancestry and East Asians.…”

Section: Discussionmentioning

confidence: 99%

Investigating the likely association between genetic ancestry and COVID-19 manifestations

Das

Ghate

2020

Preprint

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The novel coronavirus 2019-nCoV/SARS-CoV-2 infection has shown discernible variability across the globe. While in some countries people are recovering relatively quicker, in others, recovery times have been comparatively longer and numbers of those succumbing to it high.In this study, we aimed to evaluate the likely association between an individual's ancestry and the extent of COVID-19 manifestation employing Europeans as the case study. We employed 10,215 ancient and modern genomes across the globe assessing 597,573 single nucleotide polymorphisms (SNPs). Pearson's correlation coefficient (r) between various ancestry proportions of European genomes and COVID-19 death/recovery ratio was calculated and its significance was statistically evaluated. We found significant positive correlation (p=0.03) between European Mesolithic hunter gatherers (WHG) ancestral fractions and COVID-19 death/recovery ratio and a marginally significant negative correlation (p=0.06) between Neolithic Iranian ancestry fractions and COVID-19 death/recovery ratio. We further identified 404 immune response related single nucleotide polymorphisms (SNPs) by comparing publicly available 753 genomes from various European countries against 838 genomes from various Eastern Asian countries in a genome wide association study (GWAS). Prominently, we identified that SNPs associated with Interferon stimulated antiviral response, Interferon-stimulated gene 15 mediated antiviral mechanism and 2′-5′ oligoadenylate synthase mediated antiviral response show large differences in allele frequencies between Europeans and East Asians. Overall, to the best of our knowledge, this is the first study evaluating the likely association between genetic ancestry and COVID-19 manifestation. While our current findings improve our overall understanding of the COVID-19, we note that the development of effective therapeutics will benefit immensely from more detailed analyses of individual genomic sequence data from COVID-19 patients of varied ancestries.

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Section: Discussionmentioning

confidence: 99%