Author Correction: Trans-differentiation of outer hair cells into inner hair cells in the absence of INSM1

Wiwatpanit, Teerawat; Lorenzen, Sarah M.; Cantú, Jorge A.; Foo, Chuan Zhi; Hogan, Ann; Márquez, Freddie; Clancy, John; Schipma, Matthew J.; Cheatham, Mary Ann; Duggan, Anne; Garcı́a-Añoveros, Jaime

doi:10.1038/s41586-018-0795-6

Cited by 1 publication

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“…Currently, three transcription factors involved in OHC and IHC fate determination have been identified. Insm1 plays a role in critical stages of embryonic development and prevents OHCs from differentiating into IHCs [ 32 ], and deletion of Insm1 leads to the expression of IHC-specific genes. Ikzf2 is another key transcriptional regulator of OHC maturation [ 33 ], and lack of Ikzf2 in OHCs leads to the reduction of critical OHC-expressed genes while ectopic expression of Ikzf2 in IHCs up-regulates the expression of OHC-specific genes [ 33 ].…”

Section: Signaling Pathways and Transcription Factors In Hair Cell Re...mentioning

confidence: 99%

Stem Cell-Based Hair Cell Regeneration and Therapy in the Inner Ear

Qi,

Huang,

et al. 2023

Neurosci. Bull.

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Hearing loss has become increasingly prevalent and causes considerable disability, thus gravely burdening the global economy. Irreversible loss of hair cells is a main cause of sensorineural hearing loss, and currently, the only relatively effective clinical treatments are limited to digital hearing equipment like cochlear implants and hearing aids, but these are of limited benefit in patients. It is therefore urgent to understand the mechanisms of damage repair in order to develop new neuroprotective strategies. At present, how to promote the regeneration of functional hair cells is a key scientific question in the field of hearing research. Multiple signaling pathways and transcriptional factors trigger the activation of hair cell progenitors and ensure the maturation of newborn hair cells, and in this article, we first review the principal mechanisms underlying hair cell reproduction. We then further discuss therapeutic strategies involving the co-regulation of multiple signaling pathways in order to induce effective functional hair cell regeneration after degeneration, and we summarize current achievements in hair cell regeneration. Lastly, we discuss potential future approaches, such as small molecule drugs and gene therapy, which might be applied for regenerating functional hair cells in the clinic.

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Section: Signaling Pathways and Transcription Factors In Hair Cell Re...mentioning

confidence: 99%