2019
DOI: 10.7554/elife.50925.sa2
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Author response: Cyclin-dependent kinase 5 (CDK5) regulates the circadian clock

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Cited by 3 publications
(18 citation statements)
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“…3A, B, ko cells). As expected, the protein accumulation did not last longer, confirming that CDK5 is important for PER2 protein stability (Brenna et al, 2019). Subsequently, we analyzed CLOCK cellular distribution.…”
Section: Resultssupporting
confidence: 76%
See 2 more Smart Citations
“…3A, B, ko cells). As expected, the protein accumulation did not last longer, confirming that CDK5 is important for PER2 protein stability (Brenna et al, 2019). Subsequently, we analyzed CLOCK cellular distribution.…”
Section: Resultssupporting
confidence: 76%
“…CDK5 kinase activity in the SCN is diurnal, with an off/on the state under light: dark (12:12) conditions (Brenna et al,2019). To understand whether the enzymatic activity can be circadian, we challenged the hypothesis using the NIH3T3 (immortalized mouse embryonic fibroblasts) cell lines as a model system.…”
Section: Resultsmentioning
confidence: 99%
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“…For many years it was unknown whether phosphorylation could regulate this step of the circadian clock. Recent evidence suggests that CDK5 is likely to be involved in this process (Brenna et al, 2019). This kinase can phosphorylate PER2 in the SCN at Serine 394 (Ser-394) in a circadian fashion.…”
Section: The Negative Loopmentioning
confidence: 99%
“…PER2 nuclear translocation oscillates during the day. In the SCN, the total PER2 protein starts to rise at ZT 8 (Brenna et al, 2019) and peaks at ZT 16 (Nam et al, 2014), where it interacts with CKI δ/ε (Figure 3 12-16). It has been reported that CKIε targets PER2 to the proteasomal degradation (26S proteasome), via interaction with a member of the Skp-Cullin-F box (SCF) E3 ubiquitin ligase complex containing Beta-transducin repeatscontaining proteins 1-2 [β-TrCP1-2 (Reischl et al, 2007;Ohsaki et al, 2008)].…”
Section: The Negative Loopmentioning
confidence: 99%