Author response: Dopamine receptor 1 neurons in the dorsal striatum regulate food anticipatory circadian activity rhythms in mice

Gallardo, Christian M.; Darvas, Martin; Oviatt, Mia; Chang, Cheng‐Nan; Michalik, Mateusz; Huddy, Timothy F.; Meyer, Emily E.; Shuster, S. Andrew; Aguayo, Antonio; Hill, Elizabeth M.; Kiani, Karun; Ikpeazu, Jonathan; Martinez, Johan S; Purpura, Mari; Smit, Andrea N.; Patton, Danica F.; Mistlberger, Ralph E.; Palmiter, Richard D.; Steele, Andrew D.

doi:10.7554/elife.03781.023

Cited by 2 publications

(9 citation statements)

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“…Dopamine signaling is modulated by circadian machinery and, conversely, dopamine signaling influences circadian rhythms [20][21][22][30][31][32][33][34][35]. For example,…”

Section: Studies Have Shown Functional Overlap and Interactions Betmentioning

confidence: 99%

“…Daily access to food leads to anticipatory behavioral activity that may also be dependent on dopamine signaling [30,37,38]. Previous studies of mice with a constitutive knockout (KO) of D1R showed attenuated FAA, whereas D2R KO mice showed normal FAA [21,39]. The D1R KO mice had a weakened PER2 RNA expression in their striatum as well.…”

Section: Studies Have Shown Functional Overlap and Interactions Betmentioning

confidence: 99%

“…The D1R KO mice had a weakened PER2 RNA expression in their striatum as well. In mice lacking TH, viral reintroduction of dopamine production in the dorsal striatum was sufficient for FAA, suggesting that dopamine signaling to D1R neurons in the dorsal striatum permits the expression of FAA [21]. In addition, timed daily D1R agonist injection caused anticipatory activity even in mice fed ad libitum (AL), suggesting that D1R neurons can control behavioral rhythms [21].…”

Section: Studies Have Shown Functional Overlap and Interactions Betmentioning

confidence: 99%

“…In mice lacking TH, viral reintroduction of dopamine production in the dorsal striatum was sufficient for FAA, suggesting that dopamine signaling to D1R neurons in the dorsal striatum permits the expression of FAA [21]. In addition, timed daily D1R agonist injection caused anticipatory activity even in mice fed ad libitum (AL), suggesting that D1R neurons can control behavioral rhythms [21]. Taken together, these results suggested that the SN dopamine-striatal D1R neurons may constitute a critical component of the circadian response to scheduled feeding.…”

Section: Studies Have Shown Functional Overlap and Interactions Betmentioning

confidence: 99%

“…The location of the neurons responsible for the anticipation of food and other related stimuli have been elusive [9,14,15] [ 16,17]. Recent studies have implicated everything from liver-derived ketones (requiring intact period gene in the liver) [18] to neuronal expression of Reverb-ɑ (Nr1d1) [19] to dopamine receptors 1 and 2 as important for mediating FAA [20][21][22].…”

Section: Introductionmentioning

confidence: 99%

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Type 1 dopamine receptor (D1R)-independent circadian food anticipatory activity in mice

Assali

Sidikpramana

Villa

et al. 2020

Preprint

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Circadian rhythms are entrained by light and influenced by non-photic stimuli, such as feeding. The activity preceding scheduled mealtimes, food anticipatory activity (FAA), is elicited in rodents fed a limited amount at scheduled times. FAA is thought to be the output of an unidentified food entrained oscillator. Previous studies, using gene deletion and receptor pharmacology, implicated dopamine type receptor 1 (D1R) signaling in the dorsal striatum as necessary for FAA in mice. To further understand the role of D1R in promoting FAA, we utilized the Cre-lox system to create cell type-specific deletions of D1R. We were unsuccessful in obtaining conditional deletion of D1R when using transgenically driven D1R-Cre. We then created a conditional deletion of D1R in GABA neurons using Vgat-ires-Cre line, which had attenuated FAA, but the amount was higher than expected based on prior results using a constitutive knockout of D1R, D1R KODrago. This result prompted us to re-test the original D1R KODrago line, which expressed less FAA than controls, but only moderately so. To determine if genetic drift had diminished the effect of D1R deletion on FAA, we re-established the D1R KODrago knockout line from cryopreserved samples. The reestablished D1R KODrago-cryo had a clear impairment of FAA compared to controls, but still developed increased activity preceding mealtime across the 4 weeks of timed feeding. Finally, we tested a different deletion allele of D1R created by the Knockout Mouse Project. This line of D1R KOKOMP mice had a significant impairment in the acquisition of FAA, but eventually reached similar levels of premeal activity compared to controls after 4 weeks of timed feeding. Taken together, our results suggest that D1R signaling promotes FAA, but other dopamine receptors likely contribute to FAA given that mice lacking the D1 receptor still retain some FAA.

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“…Dopamine signaling is modulated by circadian machinery and, conversely, dopamine signaling influences circadian rhythms [20][21][22][30][31][32][33][34][35]. For example,…”

Section: Studies Have Shown Functional Overlap and Interactions Betmentioning

confidence: 99%

Section: Studies Have Shown Functional Overlap and Interactions Betmentioning

confidence: 99%

Section: Studies Have Shown Functional Overlap and Interactions Betmentioning

confidence: 99%

Section: Studies Have Shown Functional Overlap and Interactions Betmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Type 1 dopamine receptor (D1R)-independent circadian food anticipatory activity in mice

Assali

Sidikpramana

Villa

et al. 2020

Preprint

View full text Add to dashboard Cite

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Behavioral and Gene Regulatory Responses to Developmental Drug Exposures in Zebrafish

et al. 2022

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Developmental consequences of prenatal drug exposure have been reported in many human cohorts and animal studies. The long-lasting impact on the offspring—including motor and cognitive impairments, cranial and cardiac anomalies and increased prevalence of ADHD—is a socioeconomic burden worldwide. Identifying the molecular changes leading to developmental consequences could help ameliorate the deficits and limit the impact. In this study, we have used zebrafish, a well-established behavioral and genetic model with conserved drug response and reward pathways, to identify changes in behavior and cellular pathways in response to developmental exposure to amphetamine, nicotine or oxycodone. In the presence of the drug, exposed animals showed altered behavior, consistent with effects seen in mammalian systems, including impaired locomotion and altered habituation to acoustic startle. Differences in responses seen following acute and chronic exposure suggest adaptation to the presence of the drug. Transcriptomic analysis of exposed larvae revealed differential expression of numerous genes and alterations in many pathways, including those related to cell death, immunity and circadian rhythm regulation. Differential expression of circadian rhythm genes did not correlate with behavioral changes in the larvae, however, two of the circadian genes, arntl2 and per2, were also differentially expressed at later stages of development, suggesting a long-lasting impact of developmental exposures on circadian gene expression. The immediate-early genes, egr1, egr4, fosab, and junbb, which are associated with synaptic plasticity, were downregulated by all three drugs and in situ hybridization showed that the expression for all four genes was reduced across all neuroanatomical regions, including brain regions implicated in reward processing, addiction and other psychiatric conditions. We anticipate that these early changes in gene expression in response to drug exposure are likely to contribute to the consequences of prenatal exposure and their discovery might pave the way to therapeutic intervention to ameliorate the long-lasting deficits.

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Author response: Dopamine receptor 1 neurons in the dorsal striatum regulate food anticipatory circadian activity rhythms in mice

Cited by 2 publications

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Type 1 dopamine receptor (D1R)-independent circadian food anticipatory activity in mice

Type 1 dopamine receptor (D1R)-independent circadian food anticipatory activity in mice

Behavioral and Gene Regulatory Responses to Developmental Drug Exposures in Zebrafish

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