Author response: Eya2 promotes cell cycle progression by regulating DNA damage response during vertebrate limb regeneration

Sousounis, Konstantinos; Bryant, Donald M.; Fernandez, Jose Martinez; Eddy, Samuel S; Tsai, Stephanie; Gundberg, Gregory C; Han, Jihee; Courtemanche, Katharine; Levin, Michael; Whited, Jessica L.

doi:10.7554/elife.51217.sa2

2020

DOI: 10.7554/elife.51217.sa2

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Author response: Eya2 promotes cell cycle progression by regulating DNA damage response during vertebrate limb regeneration

Konstantinos Sousounis

Donald M. Bryant

Jose Martinez Fernandez

et al.

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Negative cell cycle regulation by Calcineurin is necessary for proper beta cell regeneration in zebrafish

Massoz,

Bergemann,

Lavergne

et al. 2023

Preprint

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Stimulation of pancreatic beta cell regeneration could be a therapeutic lead to treat diabetes. Unlike humans, the zebrafish can efficiently regenerate beta cells, notably from ductal pancreatic progenitors. To gain insight into the molecular pathways involved in this process, we established the transcriptomic profile of the ductal cells after beta cell ablation in the adult zebrafish. These data highlighted the protein phosphatase calcineurin as a new potential modulator of beta cell regeneration. We showed that calcineurin overexpression abolished the regenerative response, leading to glycemia dysregulation. On the opposite, calcineurin inhibition increased ductal cell proliferation and subsequent beta cell regeneration. Interestingly, the enhanced proliferation of the progenitors was paradoxically coupled with their exhaustion. This suggests that the proliferating progenitors are next entering in differentiation. Calcineurin appears as a guardian which prevents an excessive progenitor proliferation to preserve the pool of progenitors. Altogether, our findings reveal calcineurin as a key player in the balance between proliferation and differentiation to enable a proper beta cell regeneration.

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Negative cell cycle regulation by Calcineurin is necessary for proper beta cell regeneration in zebrafish

Massoz,

Bergemann,

Lavergne

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

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Author response: Eya2 promotes cell cycle progression by regulating DNA damage response during vertebrate limb regeneration

Cited by 1 publication

References 0 publications

Negative cell cycle regulation by Calcineurin is necessary for proper beta cell regeneration in zebrafish

Negative cell cycle regulation by Calcineurin is necessary for proper beta cell regeneration in zebrafish

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