The end milling process plays a crucial role in shaping the material into surface structures that meet the stringent requirements of these demanding industries. The present paper aims to optimize the end milling process of Al6061 with nano tungsten carbide reinforcement at 6% by studying metal removal rate (MRR), and surface finish based on the parameters of depth of cut, feed, and cutting speed. The aluminium metal matrix composite is prepared with 6 weight percentage of nano tungsten carbide is reinforced with Al6061 alloy is casted by using stir casting method. RSM analysis is used to find the best operating condition by using L9 orthogonal array. The ANOVA result shows that cutting speed is the most domineering factor which influences the MRR and feed rate is the most influencing factor on surface roughness.