The secretion of small extracellular vesicles (EVs) plays a crucial role in intercellular communication and cellular homeostasis. However, there are still many unanswered questions regarding the transport processes within the endosomal system that lead to the generation and secretion of small EVs. This review will specifically address the transport of endocytic vesicles throughout the cell and the involvement of motor proteins, particularly kinesins, in the transport of endosomal compartments destined for the secretion of EVs.