Author response: Ribosomal profiling during prion disease uncovers progressive translational derangement in glia but not in neurons

Scheckel, Claudia; Imeri, Marigona; Schwarz, Petra; Aguzzi, Adriano

doi:10.7554/elife.62911.sa2

2020

DOI: 10.7554/elife.62911.sa2

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Author response: Ribosomal profiling during prion disease uncovers progressive translational derangement in glia but not in neurons

Claudia Scheckel

Marigona Imeri

Petra Schwarz

et al.

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Glial activation in prion diseases is strictly nonautonomous and requires neuronal PrP^Sc

Lakkaraju

Sorce

Senatore

et al. 2021

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Although prion infections cause cognitive impairment and neuronal death, transcriptional and translational profiling shows progressive derangement within glia but surprisingly little changes within neurons. Here we expressed PrPC selectively in neurons, astrocytes or oligodendrocytes of mice. After prion infection, both astrocyte and neuron-restricted PrPC expression led to copious brain accumulation of PrPSc. As expected, neuron-restricted expression was associated with typical prion disease. However, mice with astrocyte-restricted PrPC expression experienced a normal life span, did not develop clinical disease, and did not show astro- or microgliosis. Besides confirming that PrPSc is innocuous to PrPC-deficient neurons, these results show that astrocyte-born PrPSc does not activate the extreme neuroinflammation that accompanies the onset of prion disease and precedes any molecular changes of neurons. This points to a nonautonomous mechanism by which prion-infected neurons instruct astrocytes and microglia to acquire a specific cellular state that, in turn, drives neural dysfunction.

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Glial activation in prion diseases is strictly nonautonomous and requires neuronal PrP^Sc

Lakkaraju

Sorce

Senatore

et al. 2021

Preprint

Self Cite

View full text Add to dashboard Cite

show abstract

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Author response: Ribosomal profiling during prion disease uncovers progressive translational derangement in glia but not in neurons

Cited by 1 publication

References 0 publications

Glial activation in prion diseases is strictly nonautonomous and requires neuronal PrP^Sc

Glial activation in prion diseases is strictly nonautonomous and requires neuronal PrP^Sc

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Author response: Ribosomal profiling during prion disease uncovers progressive translational derangement in glia but not in neurons

Cited by 1 publication

References 0 publications

Glial activation in prion diseases is strictly nonautonomous and requires neuronal PrPSc

Glial activation in prion diseases is strictly nonautonomous and requires neuronal PrPSc

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Glial activation in prion diseases is strictly nonautonomous and requires neuronal PrP^Sc

Glial activation in prion diseases is strictly nonautonomous and requires neuronal PrP^Sc