Author response to: Comment on: Effect of donor nephrectomy time during circulatory-dead donor kidney retrieval on transplant graft failure

Heylen, Line; Jochmans, Ina

doi:10.1002/bjs.11626

Cited by 4 publications

(3 citation statements)

References 7 publications

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“…However, the study did not report if this system impacted CIT but only the feasibility, safety, and effectiveness of the traction system. To our knowledge, none of the large transplant registries collect information on back-table time, although this might be a valuable variable to investigate[ 62 ].…”

Section: Cit Stepsmentioning

confidence: 99%

Cold ischemia time in liver transplantation: An overview

Cesaretti,

Izzo,

Pellegrino

et al. 2024

World J Hepatol

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The standard approach to organ preservation in liver transplantation is by static cold storage and the time between the cross-clamping of a graft in a donor and its reperfusion in the recipient is defined as cold ischemia time (CIT). This simple definition reveals a multifactorial time frame that depends on donor hepatectomy time, transit time, and recipient surgery time, and is one of the most important donor-related risk factors which may influence the graft and recipient’s survival. Recently, the growing demand for the use of marginal liver grafts has prompted scientific exploration to analyze ischemia time factors and develop different organ preservation strategies. This review details the CIT definition and analyzes its different factors. It also explores the most recent strategies developed to implement each timestamp of CIT and to protect the graft from ischemic injury.

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Section: Cit Stepsmentioning

confidence: 99%

Cold ischemia time in liver transplantation: An overview

Cesaretti,

Izzo,

Pellegrino

et al. 2024

World J Hepatol

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“…Although rewarming occurs on the back‐table, it is unknown whether donor or recipient back‐table time affects post‐transplant kidney outcomes 6,12 …”

Section: Kidneymentioning

confidence: 99%

“…Many registries do not collect these times and UNOS stopped registering implantation time in 2015 16 . To our knowledge, none of the large transplant registries collect information on back‐table time, although this might be a valuable variable to investigate 12 …”

Section: Strategies To Protect the Graftmentioning

confidence: 99%

“Time is tissue”—A minireview on the importance of donor nephrectomy, donor hepatectomy, and implantation times in kidney and liver transplantation

Heylen

Pirenne

Naesens

et al. 2021

American Journal of Transplantation

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Donor organs are exposed to sequential temperature changes during the transplantation process. The role of donor warm ischemia and cold ischemia times on post‐transplant outcomes has been extensively studied. Much less attention has been paid to the transient ischemia occurring during donor organ removal and implantation. Recently, it has become clear that prolonged donor nephrectomy and implantation time are independently associated with delayed graft function after kidney transplantation. In addition, implantation time correlates with post‐transplant kidney graft function, histology, and survival. Similar detrimental associations of donor hepatectomy and implantation time with early allograft dysfunction, ischemic cholangiopathy, and graft and patient survival after liver transplantation have been demonstrated. This review details kidney and liver temperature changes occurring during procurement and transplantation. It summarizes the effects of the ischemia the kidney and liver sustain during these phases on short‐ and long‐term post‐transplant outcomes, advocating the standardized reporting of donor hepatectomy, donor nephrectomy, and implantation times in (inter)national registries. The review also explores strategies to protect the graft from this ischemic injury.

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Comment on: Effect of donor nephrectomy time during circulatory-dead donor kidney retrieval on transplant graft failure

Straalen

Minnee

2020

British Journal of Surgery

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Author response to: Comment on: Effect of donor nephrectomy time during circulatory-dead donor kidney retrieval on transplant graft failure

Cited by 4 publications

References 7 publications

Cold ischemia time in liver transplantation: An overview

Cold ischemia time in liver transplantation: An overview

“Time is tissue”—A minireview on the importance of donor nephrectomy, donor hepatectomy, and implantation times in kidney and liver transplantation

Comment on: Effect of donor nephrectomy time during circulatory-dead donor kidney retrieval on transplant graft failure

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