Author's reply to the comment by Chow

Humble, Stephen R.; Li, L.; Dalton, Andrew

doi:10.1002/ejp.772

Cited by 1 publication

(1 citation statement)

References 5 publications

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“…Although much research has been conducted to alleviate persistent post‐surgical pain in the last few decades, the monitoring and management of this condition still remains a clinical challenge [1] . Local anesthetics (LA) have been widely accepted in recent years for postoperative analgesia, obstetric, dental pain and chronic pain management [2] . In general, LA can be divided into esters and amides according to their structure, which can reversibly and temporarily block the conduction of nerve impulses through binding to Na + channels on the nerve membrane to produce analgesic effect [3] .…”

Section: Introductionmentioning

confidence: 99%

Preparation of Ropivacaine Encapsulated by Zeolite Imidazole Framework Microspheres as Sustained‐Release System and Efficacy Evaluation

Wang

Tang

et al. 2023

Chemistry A European J

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The management of persistent postoperative pain still remains a clinical challenge currently. Although ropivacaine (RVC) is widely used for postoperative analgesia as a local anesthetic, the short half‐life makes it difficult to achieve the desired duration of analgesia. Herein, a RVC sustained‐release microspheres encapsulated by zeolite imidazole framework‐8 (RVC@ZIF‐8) was synthesized for the first time, which prolonged the sustained‐release of RVC and decreased the resulting drug toxicity. RVC can continuously release in vitro for at least 96 h with high drug loading of 30.6 % and RVC@ZIF‐8 had excellent biocompatibility and low cytotoxicity. In sciatic nerve block model, the sensory block time of RVC@ZIF‐8 was significantly prolonged compared with RVC, achieving more than 72 h post injection and no inflammation or lesion were found. Based on high drug loading, ideal sustained‐release and superior biological safety, RVC@ZIF‐8 will be a novel delivery material for local anesthetic with potential application.

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Section: Introductionmentioning

confidence: 99%