Autoantibody Panel Screening in Recurrent Miscarriages

Marai, Ibrahim; Carp, Howard; Shai, Shafrira; Shabo, Ronen; Fishman, Gadi; Shoenfeld, Yehuda

doi:10.1111/j.1600-0897.2004.00153.x

Cited by 50 publications

(38 citation statements)

References 32 publications

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“…In spite of the bulk knowledge about APA, the concept of autoimmune basis of infertility is still controversial, particularly regarding the presence of ACL [10] [11] [18]. In the present study, the significantly higher ACL IgM positivity rate in women with primary infertility was consistent with that reported by other workers [12] [14]. This may be due to the ability of ACL antibodies to cause tiny blood clots, preventing blood from flowing to the reproductive organs or placenta [6]- [8] [19].…”

Section: Discussionsupporting

confidence: 82%

“…Moreover, anti-beta2-GPI antibodies induce the activation of endothelial cells, resulting in a proinflammatory state which favors the prothrombotic diathesis of the syndrome [13]. Marai et al (2004) [14] demonstrated a significant association between ACL and anti-antiphosphatidylserine with infertility compared to control parous women. Moreover, studies suggested a possible role of ACL in failure of implantation after in vitro fertilization and embryo transfer [14] [15].…”

Section: Introductionmentioning

confidence: 99%

“…Marai et al (2004) [14] demonstrated a significant association between ACL and anti-antiphosphatidylserine with infertility compared to control parous women. Moreover, studies suggested a possible role of ACL in failure of implantation after in vitro fertilization and embryo transfer [14] [15].…”

Section: Introductionmentioning

confidence: 99%

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Association between the Presence of Serumanti-Cardiolipin Antibodies and Infertility

Hasan¹,

Hwaid²,

Mahdy³

2016

JBM

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Background: Infertility is a common problem affecting 15% -20% of couples. The increased incidence of anticardiolipin (ACL) antibodies in infertile women supports the contention that these autoantibodies contribute to the infertility. Objectives: To investigate whether there is an association between the presence of serum ACL antibodies and infertility in both men and women in Diyala province. Subjects and methods: The present study was conducted in Baquba city for the period from October 2013 to November 2014. Subjects included in this study were chosen from those attending Baquba Teaching Hospital, Al-Batool Teaching Hospital for Maternity and Children and some Primary Health Care Centers in Baquba. The subjects were categorized as follows: 30 apparently healthy males with age ranged between (18 -45) years; 30 apparently healthy women (age range: 18 -47 years) had at least two live births without any miscarriages; 25 women (age range: 18 -43 years) had reproductive failure for at least one year of marriage; 30 women (age range: 24 -44 years) with at least one live birth had no pregnancy for at least two years after last child; 40 males with primary infertility (no children after at least five years of marriage and their active sperm count was zero). Detection of anti-ACL IgG and IgM was done using enzyme-linked immunosorbant assay (ELISA) commercial kits (Wendell/Shelm/Germany). All data were statistically analyzed. Results: The results revealed that the anti-ACL IgM positivity rate was significantly higher among women with primary fertility compared to healthy women (p = 0.006). Similarly, the anti-ACL IgM and anti-ACL IgG were significantly among women with secondary infertility compared to healthy women (p = 0.012) and (p = 0.038) respectively. Although the anti-ACL IgG and IgM positivity rate among men with primary infertility was higher than that of healthy control. However, the differences were failed to reach the statistical significance (p = 0.07) and (p = 0.31) respectively. Conclusion: The presence of high levels of anticardiolipin antibodies in * Corresponding author.A.-R. Sh. Hasan et al. 96women with primary and secondary infertility as well as in men with primary infertility may support the contention that these autoantibodies contribute to the infertility in both sexes.

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Section: Discussionsupporting

confidence: 82%

Section: Introductionmentioning

confidence: 99%

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Association between the Presence of Serumanti-Cardiolipin Antibodies and Infertility

Hasan¹,

Hwaid²,

Mahdy³

2016

JBM

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“…Our study, as well as the previous research [11] [12] [15] [16] [23], has demonstrated that infectious inflammatory processes of various etiology, endocrine changes, antiphospholipid syndrome, and other disorders in the female body, as well as combinations of the above mentioned changes that have causal relationship to adverse pregnancy outcomes are accompanied by certain abnormalities in the production of embryotropic antibodies. During the preconception care after the first ELI-P-Complex testing, abnormal content of embryotropic antibodies was revealed in 92.4% (n = 2041) of Group A women.…”

Section: Discussionmentioning

confidence: 70%

“Eli-P-Complex” Diagnostic Test for Preconception Care in Women with History of Adverse Pregnancy Outcome: A Randomized Multicenter Trial

Цахилова¹,

Sharkovskaya²,

Yakimovich³

et al. 2015

ARSci

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“…Data of the literature show that anti-dsDNA may be present in 2 % of women with habitual abortions (14). Of antibodies against extractable nuclear antigens (ENA-Profile), 3-component antibody to non-histone proteins (anti-SS-A) (especially in association with elevated serum immunoglobulin E levels) as well as antibodies against ribonucleoproteins (anti-RNP), when present in high titres, may lead to abortion (14,22). As APS, that belongs to acquired thrombophilias, is usually demonstrated in patients with repeated events of thromboembolism which cannot be explained by other causes, these patients require life-long anticoagulation (2, 3).…”

mentioning

confidence: 99%

Antibodies and autoimmune diseases in relation to reproductive failures

Kovács¹

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IV. Kovacs M., Hartwig M., Aleksza M., Tihanyi M., Nagy T., Vajda Gy., Daru J., XVII. Bodorkos I., Aleksza M., Horvath E., Dancza T., Farkas A., Gyorkos A., Kovacs M., Tiboly M., Toth P., Gasztonyi B.: Haemotherapy and its serological aspects of patients suffering from immunohaematological diseases. Blood Reviews, Suppl., 21, 119., 2007. IF: 5.922XVIII. Farkas A., Kovacs M., Gyorkos A., Milics M., Nagy Gy., Tarnok F.: Serious clinical manifestations of Systemic lupus erythematosus -case report. Magyar Belorv.

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Autoantibody Panel Screening in Recurrent Miscarriages

Abstract: RM was associated with autoantibodies to aTPO and the combined panel of aTPO, aTG and anti-ENA, but not with aPL. aPL were associated with infertility.

Cited by 50 publications

References 32 publications

Association between the Presence of Serumanti-Cardiolipin Antibodies and Infertility

Association between the Presence of Serumanti-Cardiolipin Antibodies and Infertility

“Eli-P-Complex” Diagnostic Test for Preconception Care in Women with History of Adverse Pregnancy Outcome: A Randomized Multicenter Trial

Antibodies and autoimmune diseases in relation to reproductive failures

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