Autoantibody studies of female patients with reproductive failure

Serum anti-carbonic anhydrase I and II antibodies and polycystic ovary syndrome

“…Although, many organ specific antibodies were studied in PCOS, anticarbonic anhydrase antibodies have not been well studied previously. In one study, only in nine patients with PCOS, endometriosis, and unexplained infertility, the presence of anti-CA I antibodies were demonstrated [8]. However the literature review failed to show any study reporting statistically significant difference in anti-CA antibodies' levels between women with and without PCOS.…”

“…The main pathophysiologic mechanisms of PCOS are inherent ovarian dysfunction, disturbances of the hypothalamic-pituitary-ovarian axis by external and internal factors and hyperinsulinaemia [17]. Besides these, nowadays, autoimmune disturbances have also been demonstrated in some cases [6,8]. Although, many organ specific antibodies were studied in PCOS, anticarbonic anhydrase antibodies have not been well studied previously.…”

“…Several autoimmune diseases have been demonstrated in women with PCOS and in sera of those, various systemic and organ-specific autoantibodies have been recognized [6][7][8]. Some of these autoantibodies are antinuclear antibodies, anti-histone, anti-nucleosome, antidsDNA antibodies, smooth muscle cells, liver-kidney microsome, thyroid microsome, gastric parietal cell, reticulin, mithocondrial antibodies, autoimmune thyroiditis, thyroperoxidase or thyroglobulin antibodies and thyrotropin [6].…”

“…We found 13 (26%) anti-CA I and 2 (4%) anti-CA II antibody positive subjects in 50 PCOS women. It has been suggested that autoimmune mechanisms may be involved, and antibodies against different candidate auto antigens, including carbonic anhydrases as a group of metalloenzymes widely distributed in human tissues, have been demonstrated in subjects with some autoimmune diseases [8]. Although previously CA II autoantibodies have been observed in various autoimmune and idiopathic diseases, such as Systemic Lupus Erythematosus (SLE) (28.5%), Graves' disease (25%), Sjögren syndrome (SjS) (62%), and primary biliary cirrhosis (25%), rheumatoid arthritis (27.8%), endometriosis (69.6%) [8,[19][20][21], according to our findings there were no significant differences in anti-CA II antibody frequencies between PCOS patients and controls (p>0.05).…”

“…Serum anti-CA I antibodies have been reported in SLE, SjS and primary biliary cirrhosis [8,[19][20][21] . In contrast with CA II, CA I is expressed mainly in erythrocytes.…”