Autobiographical memory in temporal lobe epilepsy: Role of hippocampal and temporal lateral structures

Imagining future events in patients with unilateral temporal lobe epilepsy

“…Contrary to our hypothesis that side of lesion -particularly right-lateralized lesions -would differentially impact the ability to generate episodic events that rely heavily on contextual detail, the total AI internal detail scores were not significantly different between-patient groups. This lack of significant difference between the LTLE and the RTLE groups in construction of past and future events supports findings from previous studies that examined the role of the left-and right-sided temporal lobe seizure foci on recall of past events (Addis, Moscovitch, et al, 2007;Addis, Wong, et al, 2007;Gascoigne et al, 2013;Herfurth et al, 2010;Lah et al, 2006;Noulhiane et al, 2007;StLaurent et al, 2009;Viskontas et al, 2000;Voltzenlogel et al, 2006).…”

“…In contrast, some studies have shown that patients with LTLE have deficits in recall of semantic autobiographical details relative to either healthy control participants (Barr et al, 1990;Lah, Grayson, Lee, & Miller, 2004) or patients with RTLE (Herfurth et al, 2010) on the autobiographical knowledge section of the Goldberg-Barnett Remote Memory Battery (Goldberg & Barnett, 1985), an adopted Autobiographical Fluency Test (Dritschel, Williams, Baddeley, & Nimmo-Smith, 1992) for Names and a modified version of the Autobiographical Memory Interview (AMI; Kopelman, Wilson, & Baddeley, 1989), respectively. Between-group differences, however, in recall of semantic autobiographical details was not found in several studies (Addis, Moscovitch, et al, 2007;Addis, Wong, & Schacter, 2007;Viskontas et al, 2000;Voltzenlogel et al, 2006).…”

“…1990; Spencer, Williamson, Spencer, & Mattson, 1987). Second, patients with unilateral TLE have deficits in recall of personally experienced past events (Addis, Moscovitch, & McAndrews, 2007;Barr, Goldberg, Wasserstein, & Novelly, 1990;Herfurth, Kasper, Schwarz, Stefan, & Pauli, 2010;Lah, Lee, Grayson, & Miller, 2006;Noulhiane et al, 2007;St-Laurent, Moscovitch, Levine, & McAndrews, 2009;Viskontas, McAndrews, & Moscovitch, 2000;Voltzenlogel, Despr es, Vignal, Kehrli, & Manning, 2007) and semantic details/ facts (Barr et al, 1990;Herfurth et al, 2010;Lah et al, 2006). As recall of past personally experienced events is expected to be related to or dependent on the same mechanisms as generation of future events, patients with TLE provide an excellent opportunity to study relations/mechanisms of past and future events construction further.…”

Correlation between calbindin expression in granule cells of the resected hippocampal dentate gyrus and verbal memory in temporal lobe epilepsy

“…In patients with chronic TLE, impairment of declarative memory has been demonstrated, and epilepsy severely affects long-term delayed recall of visual and verbal information [37,38]. Some patients with a focus in the left temporal lobe could not recall autobiographical memories from their childhood [39]. Left HS correlated with impairments in verbal episodic memory while visuo-spatial working memory was affected in right HS [40,41].…”

FMRI contributions to addressing autobiographical memory impairment in temporal lobe pathology

“…Overall, memory for the past has been much less investigated than anterograde memory (i.e., acquisition of new information) in patients with TLE. However, in the last decade an increasing number of studies also explored remote memory in TLE patients [82][83][84][85][86][87][88] . They revealed that TLE affects remote memory, particularly AM, with left TLE leading to severe AM deficit.…”