Self-care in post-transplanted patients of hematopoietic progenitors at home is transcendental to improve their health conditions. The purpose of the educational activity on self-care is to establish communicative strategies to improve their situation, reducing preventable post-transplant complications and avoiding constant readmissions. The personalized counseling provided by the nurse to the patient and family members improves their quality of life. Objectives: To determine the level of self-care of patients undergoing hematopoietic progenitor transplantation in a specialized oncologic institution, 2022. Methodology: quantitative, descriptive, non-experimental, cross-sectional design. The population consisted of 108 patients attending the TAMO service, the type of sampling was probabilistic. An instrument with 2 dimensions of self-care was applied: knowledge and skills with 30 items with a Likert scale. The instrument was validated with a Cronbach's alpha of 0.8. The results show that 100% of the patients have adequate self-care. In relation to the dimensions: knowledge 94.4%, in skills 87% presented high levels respectively. It is concluded that continuing nursing education maintains solvency in self-care in the patient's daily life.