Autofluorescence and spectral-domain optical coherence tomography of optic disk melanocytoma

Clinical and Spectral-Domain Optical Coherence Tomography Appearance of Optic Disc Melanocytoma: A New Classification and Differentiation from Pigmented Choroidal Lesions

“…The SD-OCT findings of melanoma and nevus we observed were consistent with previous large series [5,6,7,8,9,10,11,12,13,14,15,16,17,18,19]. The heavily pigmented Type 1 optic disc melanocytoma is usually distinguishable from choroidal melanoma and choroidal nevus by funduscopic findings, but SD-OCT may help confirm the diagnosis and identify associated features, such as subretinal fluid, that could affect the clinical course.…”

“…These are summarized in Table 3[5,6,7,8,9,10,11,12,13,14,15,16,17,18,19]. Our cases corroborate a constellation of findings that have previously been reported and that are typical of most heavily pigmented optic disc melanocytomas: a very prominent and dense optical shadowing by the heavily pigmented tumor; a sharply demarcated interface between the tumor and a thin, hyperreflective layer of the disorganized overlying retina, and hyperreflective dots accumulated at the tumor-retina interface.…”

“…The SD-OCT features of choroidal melanoma and nevus have been well described [1,2,3,4]. While a number of case reports and small case series include limited descriptions of the corresponding features of the classic, darkly pigmented optic disc melanocytoma, these have not included the uncommon, more lightly pigmented form of the tumor [5,6,7,8,9,10,11,12,13,14,15,16,17,18,19]. We compared the features of both the classic, darkly pigmented and the atypical, more lightly pigmented optic disc melanocytoma with those of pigmented choroidal lesions.…”

Optic disc melanocytoma: a case report

“…Melanocytomas have endogenous melanin and lipofuscin that transiently emit light (autofluorescence) when exposed to a light source. However, in comparison with a malignant melanoma, they show hypoautofluorescence in FAF as seen in our patient [ 2 , 4 , 8 ]. Newer imaging modalities like Infrared autofluorescence (IRAF) and short wave autofluorescence (SWAF) have shown greater sensitivity in identifying melanocytomas [ 8 ].…”

Optic nerve melanocytoma: pathophysiology, clinical considerations, and diagnostic novelties

“…By retinal fluorescein angiography, there is hypofluorescence and autohypofluorescence 4,19,21,34,38 , probably secondary to pigmented and densely compacted cells 19.38 , with relatively little vascularization and lipofuscin absence 38 . By autofluorescence, the adjacent retina is isoautofluorescent 41 . The adjacent region of the tumor may be hyperfluorescent when it is associated papilledema 4,19 or subretinal fluid 2 (Fig.…”