Autofluorescence Imaging Videobronchoscopy Improves Assessment of Tumor Margins and Affects Therapeutic Strategy in Central Lung Cancer

Zarić, Bojan; Becker, Heinrich D.; Perin, Branislav; Stojanovic, Goran; Jovelić, Aleksandra; Eri, Zivka; Panjković, Milana; Ilić, Miroslav; Matijašević, Jovan; Milan, A.

doi:10.1093/jjco/hyp135

Cited by 27 publications

(26 citation statements)

References 21 publications

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“…11,13,40,41 AFI has shown significantly higher sensitivity in almost all the studies to date. Some studies 19,22,23,49 have found that AFI has superior specificity to WLB, while some other studies have found sim- ilar or lower specificity. 20,21,24 Whether AFI can improve detection of lung cancer or precancerous lesions is still controversial.…”

Section: Diagnostic Performance Of Afi Versus Wlbmentioning

confidence: 99%

“…Cetti et al 24 evaluated the diagnostic performance of AFI in lung cancer, and recruited patients with suspected lung cancer, and excluded patients with already diagnosed central-airway lung cancer. Zaric et al 22,23,49 evaluated AFI in the assessment of tumor extent (margins), and recruited patients with suspected lung cancer, and excluded patients with suspected or known lung cancer metastases.…”

Section: Diagnostic Performance Of Afi Versus Wlbmentioning

confidence: 99%

“…Three studies by Zaric et al 22,23,49 evaluated AFI for assessing tumor extent, and the biopsies were taken from the margins of the visualized pathologic mucosa. The other studies [19][20][21]24,50 were designed to evaluate AFI in the diagnosis of cancers and precancerous lesions, and the biopsies were taken from the cores of the suspicious areas, under either AFI or WLB.…”

Section: Diagnostic Performance Of Afi Versus Wlbmentioning

confidence: 99%

“…Some studies have found that AFI is better than WLB for detecting superficial cancers and precancerous lesions, [19][20][21][22][23] whereas some other studies have reported controversial results. 24 In this paper we describe the working mechanisms and characteristics of AFBs, mainly AFI, and the diagnostic performance of AFI for detecting lung cancers and precancerous lesions.…”

Section: Introductionmentioning

confidence: 99%

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Value of Autofluorescence Imaging Videobronchoscopy in Detecting Lung Cancers and Precancerous Lesions: A Review

Wang

et al. 2013

Respir Care

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SummaryBronchoscopy technology is a desirable method for detecting lung cancers arising in the central airways. Most early cancers and precancerous lesions are not visible on conventional white-light bronchoscopy (WLB). Autofluorescence bronchoscopy (AFB) is a newly developed technology that exploits the difference in autofluorescence intensity between normal and tumorous tissues to detect bronchial cancers and precancerous lesions. Several types of AFB systems have been used in clinical practice, and autofluorescence imaging videobronchoscopy (AFI) is one of these AFBs. In most of the studies on AFB other than AFI, AFB has provided a much higher sensitivity but a lower specificity than WLB. Regarding AFI, recent studies have reported controversial results on the sensitivity and specificity for detecting cancers and precancerous lesions, compared with WLB. In this paper we describe the working mechanisms and characteristics of AFBs, mainly AFI, and the diagnostic performance of AFI, compared with WLB, other AFBs, and narrow-band imaging, for detecting lung cancers and precancerous lesions. Key words: autofluorescence imaging videobronchoscopy; autofluorescence bronchoscopy; white-light bronchoscopy; narrow-band imaging; lung cancer; precancerous lesion. [Respir Care 2013;58(12):2150 -2159

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Section: Diagnostic Performance Of Afi Versus Wlbmentioning

confidence: 99%

Section: Diagnostic Performance Of Afi Versus Wlbmentioning

confidence: 99%

Section: Diagnostic Performance Of Afi Versus Wlbmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Value of Autofluorescence Imaging Videobronchoscopy in Detecting Lung Cancers and Precancerous Lesions: A Review

Wang

et al. 2013

Respir Care

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“…21 Recent literatures reveal that autoflourescence imaging video bronchoscopy significantly improves the assessment of central lung cancer extension and influences the therapeutic strategy and that this technique has greater sensitivity and specificity, in assessment of tumor margins, than white light bronchoscopy alone. 22,23 Thus, the application of autofluorescence bronchoscopy may also increase diagnostic yield of the procedure.…”

Section: Discussionmentioning

confidence: 99%

Diagnostic yield of conventional transbronchial needle aspiration in suspected bronchogenic carcinoma without intraluminal growth on bronchoscopy

2017

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Background: Bronchogenic carcinoma with spread along the mucosal plane presents as an exophytic mass. Most of the submucosal and peribronchial patterns of this malignancy are harder to detect by standard diagnostic procedures such as bronchial washing, brushing and forceps biopsy. We sought to investigate the utility of transbronchial needle aspiration (TBNA) in the diagnosis of bronchogenic carcinoma without intraluminal mass, through prospective analysis of routine diagnostic bronchoscopies performed in a 24-month period, at a tertiary care hospital.Methods: Patients with suspected bronchogenic carcinoma (clinical and radiological) underwent standard computed tomography (CT) of thorax. Further the patients were subjected to conventional TBNA, singly, and in combination with bronchial washings and brushings. The results were analyzed statistically for the diagnostic yield of TBNA.Results: Among the 42 patients assessed, 29 had malignancy confirmed by forceps biopsy or CT guided Fine Needle aspiration cytology or biopsy and bronchoscopy. Among them, 17 cases were detected by a combination of the results of bronchial washing, brushing and TBNA. The individual sensitivities amounted to 3.4% (n=1), 51.72% (n=15) and 27.6% (n=8), respectively. There were no false positive results. Concerning different bronchoscopic sampling techniques, 9 cases were diagnosed solely by bronchial brushings and 2 cases by TBNA alone. No periprocedural complications were encountered.Conclusions: Value of bronchial brushing in the diagnosis of bronchogenic carcinoma without bronchoscopically visible intraluminal mass is above that of conventional TBNA. Addition of bronchial washings, to bronchial brushings and TBNA has an insignificant impact on the diagnosis.

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Early Lung Cancer: Methods for Detection

Yasufuku

2012

Interventions in Pulmonary Medicine

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Autofluorescence Imaging Videobronchoscopy Improves Assessment of Tumor Margins and Affects Therapeutic Strategy in Central Lung Cancer

Abstract: Our results confirm that AFI videobronchoscopy significantly improves the assessment of central lung cancer extension and influences the therapeutic strategy. This technique has greater sensitivity and specificity, in assessment of tumor margins, than WLB alone.

Cited by 27 publications

References 21 publications

Value of Autofluorescence Imaging Videobronchoscopy in Detecting Lung Cancers and Precancerous Lesions: A Review

Value of Autofluorescence Imaging Videobronchoscopy in Detecting Lung Cancers and Precancerous Lesions: A Review

Diagnostic yield of conventional transbronchial needle aspiration in suspected bronchogenic carcinoma without intraluminal growth on bronchoscopy

Early Lung Cancer: Methods for Detection

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