Autoimmune and Neoplastic Thyroid Diseases Associated with Hepatitis C Chronic Infection

Fallahi, Poupak; Ferrari, Silvia; Politti, U; Giuggioli, Dilia; Ferri, Clodoveo; Antonelli, Alessandro

doi:10.1155/2014/935131

Cited by 26 publications

(16 citation statements)

References 119 publications

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“…Another chronic infection by hepatitis C virus (HCV) is reported to take responsibility for an increased prevalence of malignant TNs, like papillary thyroid cancer. It is attributed to the inflammatory circumstance in the thyroid gland resulted from a range of inflammatory process induced by HCV infection [21]. Thus, inflammation, especially chronic, low-grade inflammation, plays a vital role in MS, promoting TN formation.…”

Section: Discussionmentioning

confidence: 99%

A Mechanism Exploration of Metabolic Syndrome Causing Nodular Thyroid Disease

Zhang

Huang

et al. 2019

International Journal of Endocrinology

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Background Metabolic syndrome (MS) and its components have been demonstrated to facilitate the prevalence of thyroid nodules (TNs). The underlying pathogenesis needs to be elucidated. Methods A total of 2722 subjects, who underwent health checkup in our institute from December 2014 to November 2018, were retrospectively and randomly collected. After exclusion, 2068 subjects were chosen, and their anthropic and clinical data were collected. Results After matching age, gender, uric acid (UA), and creatinine (Cr) by propensity score matching (PSM), subjects with MS had higher prevalence of TNs than those without MS, as well as higher thyroid-stimulating hormone (TSH) and inflammatory levels, indicated by the higher white blood cell (WBC), lymphocyte (LY), and monocyte/high-density lipoprotein (Mo/HDL). After matching age, gender, UA, Cr, TSH, free triiodothyronine (FT3), thyroxine (FT4), WBC, NE, LY, Mo, NE/LY, LY/Mo, and Mo/HDL by PSM, no significant difference of the prevalence of TNs was found between MS and non-MS groups. Step logistic regression suggested glucose intolerance (GI), among all the components of MS, was an independent impact factor of TNs and was considered to contribute most to the formation of TNs. The prevalence of TNs was higher in the GI group after matching age, gender, body mass index (BMI), systolic blood pressure (SBP), diastolic blood pressure (DBP), fasting blood sugar (FBS), UA, Cr, triglyceride (TG), cholesterol (CHOL), HDL, and low-density lipoprotein (LDL). Conclusions Patients with MS have a higher prevalence of TNs, probably due to the elevated TSH and inflammatory levels in vivo. Among the components of MS, glucose intolerance contributes most to the development of TNs.

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Section: Discussionmentioning

confidence: 99%

A Mechanism Exploration of Metabolic Syndrome Causing Nodular Thyroid Disease

Zhang

Huang

et al. 2019

International Journal of Endocrinology

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“…However, several works have suggested that the presence of these autoantibodies in chronic HCV‐infected individuals may be associated with virus‐induced pathogenesis. Thus, HCV infection has been related to production of ATG, autoimmune and neoplastic thyroid diseases . In addition, a variable prevalence of ANA (12–65%) and SMA (33–37%) have been detected in HCV‐related MC .…”

Section: Discussionmentioning

confidence: 99%

High prevalence of a variety of autoantibodies in a population of hepatitis C virus‐infected individuals

Navarta

Espul

Acosta‐Rivero

2018

APMIS

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Hepatitis C virus (HCV) infection has been related to self-reactivity, extrahepatic manifestations and autoimmune diseases. The main goals of this work were to study the prevalence of autoantibodies and their relationship with viral titers and biochemical markers of hepatic damage in patients infected with HCV. Autoantibodies (ANA, AMA, SMA, APC, LKM, DNAds, ANCA, ATG and RF) were determined in 73 individuals with chronic HCV infection and 44 healthy volunteers. The presence of these antibodies was related to demographic variables, viral titers and biochemical parameters. A high prevalence of autoantibodies, particularly for RF, that was associated with female gender was observed in HCV-infected patients. In addition, SMA, ANA and ATG showed increased frequencies in HCV infection. Interestingly, the concurrent detection of SMA and more than one autoantibody was associated with high gGT levels. Notably, concurrent higher gGT, HCV and SMA levels were observed in male patients as compared to their female counterparts. These results indicate a relationship between HCV infection and the concurrent detection of various autoantibodies in the absence of symptoms of autoimmune diseases. They also suggest a link among the presence of a variety of autoantibodies simultaneously with SMA, increased gGT levels and HCV titers in a population of male patients.

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“…After adjusting for time of visit, Charlson comorbidity index score, and type of TCM service used, the hazard ratio of these comorbidities became less than 1 and was non-significant. This means the TCM-seeking behaviour is associated with extrahepatic diseases rather than hepatitis C. This finding might be attributed to the side effects of interferon-based antiviral therapy and the lack of satisfaction with the current conventional therapies [ 27 ].…”

Section: Discussionmentioning

confidence: 99%

Utilization and prescription patterns of traditional Chinese medicine for patients with hepatitis C in Taiwan: a population-based study

Liu

Chu

Chiang

et al. 2016

BMC Complement Altern Med

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BackgroundTo characterize the utilization of Traditional Chinese Medicine (TCM) among patients with hepatitis C (HC).MethodsThis study examined datasets from the National Health Insurance Research Database in Taiwan. One cohort, including one million patients randomly sampled from the beneficiaries of the National Health Insurance Programme from January 1 to December 31 in 2010, was chosen for this analysis. People who had at least three outpatient or inpatient records and had been diagnosed with hepatitis C virus infection from 2000 to 2010 were defined as patients with HC. Patients with HC who had at least one TCM outpatient clinical record from 2000 to 2010 were defined as TCM users (N = 5,691), whereas patients with no TCM outpatient records were defined as non-TCM users (N = 2,876). The demographic data, treatment modalities and disease distributions of TCM users were analysed.ResultsOverall, 66.4 % of the patients with HC had used TCM from 2000 to 2010. Of the TCM users, 54.1 % were female. The utilization rate of TCM increased with age and peaked in the age group of those 40 − 64 years old. Herbal remedies (52.4 %) were the most commonly used agents, followed by combination therapy (46.4 %) and acupuncture alone (1.2 %). Patients who had more extrahepatic diseases and were taking more antiviral agents tended to visit TCM clinics. Jia-Wei-Xiao-Yao-San and Dan-Shen (Salvia miltiorrhiza) were the most commonly used formula and single herb, with 88,124 person-days and 59,252 person-days, respectively.ConclusionsOur nationwide population-based study revealed a high prevalence and specific usage patterns of TCM in patients with HC in Taiwan.

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Autoimmune and Neoplastic Thyroid Diseases Associated with Hepatitis C Chronic Infection

Cited by 26 publications

References 119 publications

A Mechanism Exploration of Metabolic Syndrome Causing Nodular Thyroid Disease

A Mechanism Exploration of Metabolic Syndrome Causing Nodular Thyroid Disease

High prevalence of a variety of autoantibodies in a population of hepatitis C virus‐infected individuals

Utilization and prescription patterns of traditional Chinese medicine for patients with hepatitis C in Taiwan: a population-based study

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