2024
DOI: 10.1111/cns.70042
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Autoimmune astrocytopathy double negative for AQP4‐IgG and GFAP‐IgG: Retrospective research of clinical practice, biomarkers, and pathology

Pei‐Hao Lin,
Hai‐Yan Yao,
Li Huang
et al.

Abstract: ObjectiveThe objective of this study is to investigate the presence of astrocyte antibodies in patients, excluding aquaporin‐4 or glial fibrillary acidic protein (GFAP) antibodies, while evaluating associated biomarkers and pathologies.MethodsPatient serum and cerebrospinal fluid (CSF) were tested for antibodies using tissue‐ and cell‐based assays. Neurofilament light chain (NFL) and GFAP in the CSF were detected using single‐molecule array (SIMOA).Results116 patients accepted SIMOA. Fifteen functional neurolo… Show more

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