Autoimmune component in the etiology of sarcoidosis

Старшинова, Анна; Малкова, Анна; Зинченко, Ю. С.; Basantsova, Natalia; Кудлай, Д. А.; Яблонский, П. К.

doi:10.21292/2075-1230-2020-98-5-54-62

Cited by 9 publications

(5 citation statements)

References 46 publications

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“…Currently, there is an evidence of the trigger role of M. tuberculosis in the development of diseases such as sarcoidosis, systemic lupus erythematosus, rheumatoid arthritis, primary biliary cirrhosis and many others ( 11 , 19 , 38 – 40 ).…”

Section: Discussionmentioning

confidence: 99%

“…The concept of The autoimmune/inflammatory syndrome induced by adjuvants (ASIA), proposed in 2011 by Shoenfeld Y et al. and the beginning of research on various pathological processes within ASIA, opened new perspectives for understanding of several granulomatosis diseases, for example sarcoidosis, as an autoimmune pathology ( 16 – 19 ).…”

Section: Introductionmentioning

confidence: 99%

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Identification of autoimmune markers in pulmonary tuberculosis

et al. 2023

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IntroductionPathogenesis of many autoimmune diseases is mainly promoted by poorly regulated and/or wrong targeted immune response to pathogens including M. tuberculosis. Autoimmunity is one of the processes with are characteristics of tuberculosis (Tbc). The aim was to determine the autoimmune clinical and immunological features in patients with pulmonary Tbc.Materials and methodsA prospective comparative study was performed in 2017 – 2019 with the inclusion of 46 patients with Tbc. The trigger factors and clinical manifestations, autoantibodies, peripheral blood B cell subsets were stained with fluorochrome-conjugated monoclonal antibodies. 40 healthy volunteers in the control group, were matched for age with no chronic diseases, contacts with TB patients and changes in their laboratory parameters. A statistical analysis was done with GraphPad Prism 6, Statistica 10 (Statsoft) and MedCalc – version 18.2.1 values.ResultsThere were no significant ASIA triggers in Tbc patients and control group. 21.1% of Tbc patients had a high level of a rheumatoid factor and in 47.4% complement system factor C3 was high; anti-MCV was detected in 60.7% of Tbc patients. Relative and absolute frequencies of “naïve” Bm1 cells and eBm5 were significantly decreased and activated pre-germinal-center Bm2’ cells were significantly increased in Tbc patients. The CD24++CD38++ B cells were increased in Tbc vs control group (10.25% vs 5.42%), p < 0.001, and 19 cell/1μL (10; 290 vs 11 cell/1μL (6; 20), p = 0.029, respectively). The frequency of CXCR3+CCR4– Tfh1 cells was significantly lower in Tbc vs control one (26.52% vs. 31.00%, p = 0.004), while CXCR3–CCR4+ Tfh2 cells were increased in Tbc (20.31% vs. controls (16.56%, p = 0.030). The absolute numbers of Tfh1 cells were decreased in the Tbc vs. control (24 cell/1μL vs. 37 cell/1μL p = 0.005).ConclusionThe results of our study showed that the detection of a rheumatoid factor, the components of complement system and anti-MCV in complex with alterations in B cells and follicular Th cell subsets may indicate a presence of autoimmunity in the pathogenesis of tuberculosis, but they are not specific. The indicators of autoimmune-related provide new opportunities in the Tbc treatment.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Identification of autoimmune markers in pulmonary tuberculosis

et al. 2023

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“…In some cases when it is impossible to eliminate the pathogen or chronic autoimmune inflammation develops ( 6 , 24 – 26 ), collagen overproduction in the area of granulomas is induced, which eventually causes fibrosis and substitution of lung tissue with connective tissue. Fibrotic changes start at the periphery of granulomas and extend centrally ( 27 ).…”

Section: The Pathogenesis Of Sarcoidosis Progressionmentioning

confidence: 99%

Sarcoidosis: Progression to the chronic stage and pathogenic based treatment (narrative review)

et al. 2022

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Many factors confirm the autoimmune nature of sarcoidosis and help in determining the strategy of patient management and treatment initiation. However, the causes and the mechanisms of disease progression that result in fibrosis and insufficiency of the affected organ remain unclear. This narrative review aims to analyse the mechanisms and biomarkers of sarcoidosis progression, as well as the pathogenetic basis of sarcoidosis therapy. The following characteristics of progressive chronic sarcoidosis were revealed: the disease develops in patients with a genetic predisposition (SNP in genes GREM1, CARD15, TGF-β3, HLA-DQB1*06:02, HLA-DRB1*07/14/15), which contributes either the decreased ability of antigen elimination or autoimmune inflammation. Various prognostic biomarkers of disease progression (decreased levels of neopterin, elastase, sIL-2R, chitotriosidase, glycoprotein Krebs von den Lungen, Th17 cell count, reduced quantity of TNF-α in peripheral blood or bronchoalveolar lavage fluid) have been described and can potentially be used to determine the group of patients who will benefit from the use of corticosteroids/cytostatic drugs/biologics.

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“…The theory of autoimmune/inflammatory syndrome, induced by adjuvants (ASIA) was developed by Professor Y. Shoenfeld. This new data opened up new ways of understanding the pathogenesis of sarcoidosis [11,12].…”

Section: Introductionmentioning

confidence: 99%

Sarcoidosis and Autoimmune Inflammatory Syndrome Induced by Adjuvants

Старшинова

Zinchenko

Малкова

et al. 2023

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Currently, sarcoidosis remains one of the diseases with unknown etiology, which significantly complicates its diagnosis and treatment. Various causes of sarcoidosis have been studied for many years. Both organic and inorganic trigger factors, provoking the development of granulomatous inflammation are considered. However, the most promising and evidence-based hypothesis is the development of sarcoidosis as an autoimmune disease, provoked by various adjuvants in genetic predisposed individuals. This concept fits into the structure of the autoimmune/inflammatory syndrome, induced by adjuvants (ASIA) that was proposed in 2011 by Professor Shoenfeld Y. In this paper, the authors reveal the presence of major and minor ASIA criteria for sarcoidosis, propose a new concept of the course of sarcoidosis within the framework of ASIA, and point out the difficulties in creating a model of the disease and the selection of therapy. It is obvious that the data obtained not only bring us closer to understanding the nature of sarcoidosis, but also potentiate new studies confirming this hypothesis by obtaining a model of the disease.

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Autoimmune component in the etiology of sarcoidosis

Cited by 9 publications

References 46 publications

Identification of autoimmune markers in pulmonary tuberculosis

Identification of autoimmune markers in pulmonary tuberculosis

Sarcoidosis: Progression to the chronic stage and pathogenic based treatment (narrative review)

Sarcoidosis and Autoimmune Inflammatory Syndrome Induced by Adjuvants

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