Autoimmune Hepatitis: A Classic Autoimmune Liver Disease

Moy, Libia; Levine, Jeremiah

doi:10.1016/j.cppeds.2014.10.005

Cited by 15 publications

(18 citation statements)

References 42 publications

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“…Thus, the upregulation of vimentin, at day 1 pi, might be an indirect effect provoked by E75CV1 infection on surrounding non-infected cells. Coincidently, vimentin and other proteins specifically upregulated at day 1 pi with E75CV1, such as HSPB1, enolase or LCP-1 (Additional file 1), share both their potential role in immune defense and their description as autoantigens in autoimmune disorders [34]. In particular, the role of HSPs as immunogenic molecules able to activate T cells has been long known [35] and several reports have shown that pretreatment with HSPs protects from autoimmune disease [36].…”

Section: Table 6 Analysis Of the Canonical Pathways Corresponding To mentioning

confidence: 99%

Comparative proteomic analysis reveals different responses in porcine lymph nodes to virulent and attenuated homologous African swine fever virus strains

Herrera-Uribe

Jiménez-Marín

Lacasta

et al. 2018

Vet Res

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African swine fever (ASF) is a pathology of pigs against which there is no treatment or vaccine. Understanding the equilibrium between innate and adaptive protective responses and immune pathology might contribute to the development of strategies against ASFV. Here we compare, using a proteomic approach, the course of the in vivo infection caused by two homologous strains: the virulent E75 and the attenuated E75CV1. Our results show a progressive loss of proteins by day 7 post-infection (pi) with E75, reflecting tissue destruction. Many signal pathways were affected by both infections but in different ways and extensions. Cytoskeletal remodelling and clathrin-endocytosis were affected by both isolates, while a greater number of proteins involved on inflammatory and immunological pathways were altered by E75CV1. 14-3-3 mediated signalling, related to immunity and apoptosis, was inhibited by both isolates. The implication of the Rho GTPases by E75CV1 throughout infection is also evident. Early events reflected the lack of E75 recognition by the immune system, an evasion strategy acquired by the virulent strains, and significant changes at 7 days post-infection (dpi), coinciding with the peak of infection and the time of death. The protein signature at day 31 pi with E75CV1 seems to reflect events observed at 1 dpi, including the upregulation of proteosomal subunits and molecules described as autoantigens (vimentin, HSPB1, enolase and lymphocyte cytosolic protein 1), which allow the speculation that auto-antibodies could contribute to chronic ASFV infections. Therefore, the use of proteomics could help understand ASFV pathogenesis and immune protection, opening new avenues for future research.Electronic supplementary materialThe online version of this article (10.1186/s13567-018-0585-z) contains supplementary material, which is available to authorized users.

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Section: Table 6 Analysis Of the Canonical Pathways Corresponding To mentioning

confidence: 99%

Comparative proteomic analysis reveals different responses in porcine lymph nodes to virulent and attenuated homologous African swine fever virus strains

Herrera-Uribe

Jiménez-Marín

Lacasta

et al. 2018

Vet Res

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“…When elevation of transaminase occurs in idiosyncratic DILI, mitochondrial dysfunction is already present, which leads to hepatocyte death. In contrast, liver injury due to viral infection or autoimmunity is induced by an immune response to antigens on the hepatocytes . The different pathophysiological causes of liver damage may explain the variable responses to immunosuppression therapy: AIH‐induced ALI/ALF responds well to immunosuppression therapy, while drug‐induced ALI/ALF does not …”

Section: Discussionmentioning

confidence: 99%

“…In contrast, liver injury due to viral infection or autoimmunity is induced by an immune response to antigens on the hepatocytes. [39][40][41][42] The different pathophysiological causes of liver damage may explain the variable responses to immunosuppression therapy: AIHinduced ALI/ALF responds well to immunosuppression therapy, while drug-induced ALI/ALF does not. 6 During the review process, we analyzed diagnostic efficacy of IP-10, SOD2 and CK-18F to predict DILI development using receiver-operator curve analysis.…”

Section: Discussionmentioning

confidence: 99%

Serum markers for mitochondrial dysfunction and cell death are possible predictive indicators for drug‐induced liver injury by direct acting antivirals

Kakisaka

Yoshida

Suzuki

et al. 2017

Hepatology Research

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Aim:We prospectively screened patients treated with direct-acting antivirals (DAA) in order to detect and analyze serum markers that are present prior to the development of drug-induced liver injury (DILI). Methods:The levels of various serum markers among DILI, non-DILI and control groups were compared. The DILI group consisted of eight patients whose alanine aminotransferase (ALT) levels exceeded 32 IU/L during the DAA treatment. Eight patients without DILI were selected for the non-DILI group via a matched-group design based on age, sex and disease severity. Additionally, eight healthy volunteers were employed as the controls. Serum measurements of cytokines/chemokines, cytokeratin-18 fragment (CK-18F) and super oxidase dismutase-2 (SOD2) were evaluated on the date at which hepatitis C virus RNA was absent (baseline). For patients with DILI, serum measurements taken before treatment, 1 week before pronounced transaminase elevation (prominence-1 W) and on the date at which pronounced elevation of transaminase occurred (prominence) were also evaluated.Results: All patients treated with DAA had normalized transaminase levels at baseline. In patients with DILI, interferon-inducible protein-10 (IP-10) levels were higher at prominence-1 W than at baseline. Those patients also had significantly higher levels of SOD2 and CK-18F at prominence-1 W than at baseline.Conclusion: Elevated IP-10 may be a preconditioning chemokine for DAA-induced liver injury, and damage markers associated with cell death and mitochondrial dysfunction are potential predictive serum markers for DILI.

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“…dIscusIón La HAI es una enfermedad heterogénea con edad de presentación variable que afecta a cualquier raza, y, de no ser tratada, puede progresar de forma frecuente a cirrosis 10 . El sistema de puntaje inicial descrito en 1999 tiene la posibilidad de ser aplicado antes o después del tratamiento inmunosupresor (Ver Tabla 1) 13 .…”

Section: Presentación De Caso Clínicounclassified

“…A pesar de no conocerse la causa específica de la enfermedad, se considera que se desarrolla en personas con predisposición genética que se exponen a algún agente desencadenante como bacterias, virus, hongos u otras partículas externas al organismo 9,10 ; la caracterización del cuadro clínico es de amplio rango presentándose desde formas asintomáticas solo detectables por elevaciones moderadas de las aminotransferasas hasta casos de hepatitis severa fulminante 1, 11,12 . De esta forma, la mayoría de los pacientes son asintomáticos o presentan formas leves de la enfermedad, siendo los síntomas generales inespecíficos como astenia, fatiga y debilidad un motivo de consulta frecuente.…”

Section: Introductionunclassified

Bacteremia por Aeromonas caviae en paciente con hepatitis autoinmune: presentación de caso

Díaz

Figueroa

Rivera

2017

revmed

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RESUMENLa hepatitis autoinmune es una enfermedad inflamatoria hepática mediada por un mecanismo de autoinmunidad. Este trastorno tiene un amplio espectro clínico y debe ser sospechado en presencia de elevación de inmunoglobulinas y aminotransferasas en un paciente con histopatología positiva para hepatitis. El diagnóstico se realiza descartando otras causas de hepatitis (viral, secundaria a medicamentos) y complementado con los estudios de autoanticuerpos típicos de esta enfermedad. El tratamiento se fundamenta en la monoterapia con corticoesteroides o su asociación con otros inmunomoduladores, obteniéndose buenas tasas de respuesta terapéutica. La tasa de infección hospitalaria en pacientes con cirrosis hepática oscila entre 32-34% siendo la bacteremia la cuarta fuente más frecuente, la cual tiene como etiología al género Aeromonas en un 5%. Se presenta el caso de una paciente de 51 años con hepatitis autoinmune quien consulta por descompensación de enfermedad hepática secundaria a bacteremia por un microorganismo poco común. MÉD.UIS. 2017;30(3):121-7.Palabras claves: Hepatitis Autoinmune. Bacteremia. Aeromonas. Autoanticuerpos. Autoinmunidad. Bacteremia caused by Aeromonas caviae in-patient with autoinmune hepatitis: case report ABSTRACTAutoimmune hepatitis is an inflammatory hepatic disease mediated by an autoimmune mechanism. This disorder has a broad clinical spectrum and should be suspected in the presence of elevated aminotransferases and immunoglobulins in a patient with histopathology hepatitis. Diagnosis is made by ruling out other causes of hepatitis (viral, secondary to drugs) and confirmation with positive autoantibodies. Treatment is based on corticosteroid monotherapy or its association with other immunomodulators, obtaining good therapeutic response rates. Rate of hospital infection in patients with hepatic cirrhosis ranges from 32-34%, with bacteremia being the fourth most frequent source, where Aeromonas represents 5% of these cases. We report the case of a 51-year-old patient with autoimmune hepatitis who consults for decompensation of secondary liver disease with a rare microorganism. MÉD.UIS. 2017;30(3):121-7.

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Autoimmune Hepatitis: A Classic Autoimmune Liver Disease

Cited by 15 publications

References 42 publications

Comparative proteomic analysis reveals different responses in porcine lymph nodes to virulent and attenuated homologous African swine fever virus strains

Comparative proteomic analysis reveals different responses in porcine lymph nodes to virulent and attenuated homologous African swine fever virus strains

Serum markers for mitochondrial dysfunction and cell death are possible predictive indicators for drug‐induced liver injury by direct acting antivirals

Bacteremia por Aeromonas caviae en paciente con hepatitis autoinmune: presentación de caso

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