Due to the COVID-19 pandemic’s high death rate and rapid spread, an effective vaccination is urgently needed. The detrimental consequences of the COVID-19 vaccination have received a lot of attention in reports on the vaccine’s side effects. The liver problem that appears after getting the COVID-19 immunization causes clinical hepatology considerable concern. Hepatitis is one of the clinical issues that the COVID-19 vaccine may cause. Often, the autoimmune pathogenic process is mentioned in relation to the pathophysiology. Although the precise cause of the COVID-19 vaccine-related liver dysfunction is not yet understood, immunopathological mechanisms are likely to be involved.