Autoimmune-Like Hepatitis

Abstract

A 59-year-old female received a matched related donor stem cell transplant for chronic myelogenous leukemia. After being successfully treated with prednisone for chronic graft versus host disease that initially started 50 days posttransplant, she developed hepatic dysfunction during the steroid taper on day 531, as evidenced by jaundice, elevated liver enzymes, and increased bilirubin. Liver biopsy showed histology suggestive of autoimmune-like hepatitis, which is a rare manifestation of chronic "hepatitic" graft versus host disease.

Evaluation and Determination of Tramadol and Methadone in Vitreous Samples With the Aid of Dispersive Liquid-Liquid Microextraction- High Performance Liquid Chromatography

“…Blood is still considered the first choice in the toxicological analysis, but it may not be available in many situations, or because corruption cannot be used for measurement. Therefore, the role and importance of other body environments will be further enhanced Vitreous toxicology analyzes have many benefits [42] . Vitreous fluid due to simple sampling without the need for autopsy is one of the samples to be considered in forensic medicine and also after death [43], blood contamination and bacteria are relatively safe .…”