Autoimmune Lymphoproliferative Syndrome

Cojocaru, Manole; Cojocaru, Inimioara Mihaela; Siloşi, Isabela; Vrabie, Camelia Doina

doi:10.2478/v10011-010-0006-y

Cited by 27 publications

(52 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…According to the information found in literature, the risk of progression during years for patients with risk factors 0, 1, 2 or 3 is: 5%, 21%, 37% or 58%, respectively. In a study done by Mayo Clinic, 73% of examinees were of IgG class, 14% IgM, 11% IgA and 2% were biclonal (21,22). Our results show similar distribution of Ig classes, except for the IgM and IgA classes that are almost twice less present (Table III).…”

Section: Discussionsupporting

confidence: 71%

Free Light Chains of Immunoglobulin as a Prognostic Factor for Some Plasmaproliferative Diseases

Mijusković¹,

Radović²,

Pejović³

et al. 2011

Journal of Medical Biochemistry

View full text Add to dashboard Cite

Kratak sadr`aj: Kvantitativno odre|ivanje monoklonskih imunoglobulina i njihovih fragmenata koristi se za pra}enje toka i terapijskog odgovora kod plazmaproliferativnih bolesti. Cilj odre|ivanja slobodnih lakih lanaca imunoglobulina u seru mu bolesnika jeste provera zna~aja njihovog koli~nika (k/l indeks) kao prognosti~kog faktora remisije, progresije i pre `ivlja vanja. Koncentracije imunoglobulina i slobodnih lakih lanaca odre|ivane su imunonefelometrijskom metodom na analizatoru SIEMENS DADE Behring II sa reagensima (FREELITE, The Binding Site, UK). U ispitivanje je uklju~en 151 bolesnik tokom perioda od 7 godina, koji su razvrstani u 3 grupe: 1. bolest lakih lanaca ili Bence Jones mijelom (37); 2. biklo nalna gamapatija sa slobodnim lakim lancima (23) i 3. mo no klonska gamapatija neutvr|enog znaaja (91). Referen tnim intervalom za k/l indeks smatraju se vrednosti 0,26-1,65. Prema Internacionalnom progno znom indeksu za multipli mijelom, kao patolo{ki uzet je k/l indeks <0,03 ili >32. Bolesnici iz prve dve grupe sa pato lo{kim k/l inde ksom i kombinacijom nepovoljnih faktora rizika (76,7%) imali su prose~no vreme pre`ivljavanja 22-30 meseci, nasuSummary: Quantitation of monoclonal immuno globulins and their fragments is used for moni to ring the plasmaproliferative disease course and the effect of therapy. The aim of free light chains examination was to evaluate the significance of the FLC ratio as a prognostic factor for remis sion, progression and survival in different disease groups. The concentrations of immunoglobulins and free light chains were measured by an immunonep he lometric method on a »SIEMENS« DADE BN II analyser with reagents (Freelite, The Binding Site, UK). In this examination 151 patients from 3 different disease groups: 1. Light chain disease or Bence Jones myeloma (37), 2. Biclonal gammopathy with FLC (23) and 3. Mono clonal gam mo pathy of undetermined significance (91), were investi gated during a period of 7 years. The reference interval for FLC ratio is 0.26-1.65. According to the Inter national Staging System for multiple myeloma, a serum FLC ratio of <0.03 or >32 was taken as abnormal. The patients with light chain disease and biclonal gammopathy with FLC with an abnormal FLC ratio and a combination of adverse risk factors (76.7%) had median survival times of 22-30 months, versus patients with a normal or slightly varied

show abstract

Section: Discussionsupporting

confidence: 71%

Free Light Chains of Immunoglobulin as a Prognostic Factor for Some Plasmaproliferative Diseases

Mijusković¹,

Radović²,

Pejović³

et al. 2011

Journal of Medical Biochemistry

View full text Add to dashboard Cite

show abstract

“…It is estimated that Lp‐PLA2 may be a predictive biomarker of sub‐clinical inflammation in cardiovascular diseases including ischemia stroke . Increasing evidence have revealed the influence of Lp‐PLA2 on ischemia stroke may be genetically determined . In the previous cross‐sectional study in Japanese population, Wang et al .…”

Section: Discussionmentioning

confidence: 99%

Association of Lp‐PLA2 G994T gene polymorphism with risk of ischemic stroke in Chinese population

Ni¹,

Gu²,

Hu³

et al. 2017

J Biochem & Molecular Tox

View full text Add to dashboard Cite

The association between lipoprotein-associated phospholipase A2 (Lp-PLA2) G994T gene polymorphism and the risk of ischemic stroke is unclear. The aim of this study is to investigate the influence of Lp-PLA2 G994T genetic variant on the pathogenesis of ischemic stroke in Chinese population. A total of 348 patients with a clinical diagnosis of ischemic stroke and 260 gender-matched control subjects under physical examination were recruited from hospitals and genotyped for G994T gene polymorphism. The results showed that there was a significant difference in the genotype distribution between the two groups and people with GT or TT genotype were associated with the higher risk of ischemic stroke even after adjusting the effects of potential confounding factors. In addition, both ischemic stroke patients and control subjects carrying T allele showed relatively lower Lp-PLA2 activity and higher oxLDL level. Therefore, Lp-PLA2 G994T gene polymorphism may be an independent risk factor of ischemic stroke in Chinese population.

show abstract

“…It was followed by the association between RA, SS and Graves' disease (20% of cases). Indeed, SS and Graves' disease are the autoimmune diseases most frequently associated with polyautoimmunity [2] [43]. Anaya, in her systematic review on polyautoimmunity during SS, found that the autoimmune diseases that were frequently associated with it, were autoimmune thyroiditis, RA, SLE, SSC.…”

Section: Discussionmentioning

confidence: 99%

“…The presence of 5 autoimmune diseases in a MAS is an exceptional situation [14] [29] [30] [32] [43]. MAS fitted both Humbert and Dupont types 2 and 3 in 18 cases (72%), type 2 in 5 cases (20%) and type 3 in 1 case (4%).…”

Section: Discussionmentioning

confidence: 99%

Multiple Autoimmune Syndrome: A Study of 25 Senegalese Cases

Niasse¹,

Kane²,

Mabom³

et al. 2020

OJRA

View full text Add to dashboard Cite

Introduction: Multiple autoimmune syndrome is rarely described in the African literature. We report 25 cases. Patients and Method: A Retrospective, descriptive study was carried out in the Rheumatology Department of Aristide Le Dantec University Hospital in Dakar from 2013 to September 2019. Patients with at least 3 distinct autoimmune diseases were included. Results: Twenty-five cases of multiple autoimmune syndrome were collected in 23 women and 2 men, with a mean age of 42.4 years (extremes: 24 and 67 years). The mode of discovery of the disease was a connective tissue disease in 19 cases (76%) and an organ-specific autoimmune disease in 6 cases. According to Humbert and Dupond's classification, 18 patients (72%) had both type 2 and type 3 criteria. An isolated type 2 was noted in 5 cases (20%) and an isolated type 3 in 1 case (4%). One case (4%) was unclassifiable. The evolution under treatment was marked by remission in 84% of cases. Conclusion: Multiple autoimmune syndromes account for 5.66% of the autoimmune diseases in our study. They predominate in young women with a mean age of 42.4 years. Not all entities were classifiable by the Humbert and Dupond's classification. The evolution under treatment was marked by remission in 84% of cases.

show abstract

Autoimmune Lymphoproliferative Syndrome

Cited by 27 publications

References 14 publications

Free Light Chains of Immunoglobulin as a Prognostic Factor for Some Plasmaproliferative Diseases

Free Light Chains of Immunoglobulin as a Prognostic Factor for Some Plasmaproliferative Diseases

Association of Lp‐PLA2 G994T gene polymorphism with risk of ischemic stroke in Chinese population

Multiple Autoimmune Syndrome: A Study of 25 Senegalese Cases

Contact Info

Product

Resources

About