Autoimmune meningitis and encephalitis in adult-onset still disease – Case report

Bożek, Milena; Konopko, Magdalena; Wierzba-Bobrowicz, Teresa; Witkowski, Grzegorz; Makowicz, Grzegorz; Sienkiewicz-Jarosz, Halina

doi:10.1016/j.pjnns.2017.06.006

Cited by 8 publications

(4 citation statements)

References 27 publications

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“…At present, despite the poor outcome in several patients, AOSD remains a multi-systemic disorder of unknown etiology, which is difficult to diagnose and scarcely studied. To the best of the authors' knowledge, the number of studies on AOSD is relatively low, and in Poland the epidemiology of this disease has not been fully elucidated [26,27,28,29,30]. Table 1.…”

Section: Introductionmentioning

confidence: 99%

Adult-onset Still’s disease in Poland – a nationwide population-based study

Bogdan

Nitsch–Osuch

Samel-Kowalik

et al. 2021

Ann Agric Environ Med.

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Introduction. Adult-onset Still's disease (AOSD) is a rare systemic inflammatory disorder of unknown etiology, which affects young adults and is associated with multiple organ involvement and life-threatening complications. The aim of the study was to establish the incidence and prevalence of AOSD in Poland, and factors related to this disease among hospitalized patients. Materials and method. A retrospective, population-based study was conducted, using data from hospital discharge records compiled by the National Institute of Public Health in 2009-2018. Results. Based on hospitalization records and census data in a group of the 1,050 patients included in the study, women were predominant (60%) and patients' mean and median ages at hospitalization were 42 (95% CI: 40.8-42.8) and 38 years, respectively. The average annual incidence rate of AOSD during the 10-year period was established at the level of 0.32/100,000 (95% CI: 0.30-0.34), and the point prevalence at the end of 2018 was 2.7/100,000. The most common comorbidities were: cardiovascular diseases (14%), diseases of the musculoskeletal system and connective tissue (14%), endocrine, nutritional and metabolic diseases (9%). Conclusions. AOSD is a rare disease Poland with gender and territorial differences in incidence ratek, and predominance of cardiovascular diseases among comorbidities. The presented data may be useful for comparisons of the Polish population with other geographical regions. Predominance of patients from urban regions and predominance of women may suggest environmental and personal factors in AOSD development; however, further research seems to be necessary.

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Section: Introductionmentioning

confidence: 99%

Adult-onset Still’s disease in Poland – a nationwide population-based study

Bogdan

Nitsch–Osuch

Samel-Kowalik

et al. 2021

Ann Agric Environ Med.

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“…3 Till now, only ten cases of aseptic meningitis have been described in the literature. [5][6][7][8][9][10][11] Most of the reported cases are relatively young and have neutrophilic leukocytosis in the CSF. Our patient was unique in two aspects, i.e., her age at presentation and her CSF picture.…”

Section: Discussionmentioning

confidence: 99%

Adult-Onset Still’s Disease in an Elderly Patient Presenting as Aseptic Meningitis: A Case Report

Risal,

Dhungana,

Ghimire

2023

Clin Med�Insights�Arthritis�Musculoskelet Disord

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Adult-onset Still’s disease (AOSD) is a rare auto-inflammatory disease of unknown origin characterized mainly by fever, arthritis, and a rash. Aseptic meningitis is a rare complication of AOSD and is seen most commonly in young adults. Here, we report a case of AOSD in a 78-year female with fever and altered sensorium with lymphocyte predominant pleocytosis in the cerebrospinal fluid who was initially managed as tubercular meningitis. Adult-onset Still’s disease was diagnosed as there was no response to antitubercular drugs even after 3 months and based on persistent fever, inflammatory arthritis, rash, and highly raised inflammatory markers.

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“…Imaging data on damage to other organs are scarce and are often case reports. Periportally increased T2 intensity on the liver [22], myocarditis [23], or central nervous system inflammation [24] have been reported.…”

Section: Radiologicalmentioning

confidence: 99%

Strategy and Challenges of Paraclinical Examinations in Adult-Onset Still’s Disease

Poursac

Odriozola

Truchetet

2022

JCM

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Adult-onset Still’s disease is a complex autoinflammatory disease with a multifactorial etiology. Its presentation is less stereotypical than that of a monogenic autoinflammatory disease and is actually relatively common with few specific signs. To avoid under- or over-prescription of complementary examinations, it is useful to advance in a structured manner, taking into consideration the actual added value of each supplemental examination. In this review, we detail the different complementary tests used in adult Still’s disease. We consider them from three different angles: positive diagnostic approach, the differential diagnosis, and the screening for complications of the disease. After discussing the various tests at our disposal, we look at the classical diagnostic strategy in order to propose a structured algorithm that can be used in clinical practice. We conclude with the prospects of new complementary examinations, which could in the future modify the management of patients.

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Autoimmune meningitis and encephalitis in adult-onset still disease – Case report

Abstract: Adult-onset Still disease is a rare cause of inflammatory changes in central nervous system, which if diagnosed, may be treated successfully with steroids (commonly available agent), intravenous immunoglobulins or more specific immunomodulating regiments.

Cited by 8 publications

References 27 publications

Adult-onset Still’s disease in Poland – a nationwide population-based study

Adult-onset Still’s disease in Poland – a nationwide population-based study

Adult-Onset Still’s Disease in an Elderly Patient Presenting as Aseptic Meningitis: A Case Report

Strategy and Challenges of Paraclinical Examinations in Adult-Onset Still’s Disease

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