Autoimmune pancreatitis, a single centre experience within the United Kingdom

Risk Factors for Rate of Relapse and Effects of Steroid Maintenance Therapy in Patients With Autoimmune Pancreatitis: Systematic Review and Meta-analysis

“…Finally, 72 studies (62 full-text articles and 10 abstracts) were included in a qualitative synthesis and full-text was reviewed to establish eligibility for quantitative analysis. After review of the studies, 31 full-text articles 6,9,11,12, and 5 abstracts [51][52][53][54][55] (1 randomized clinical trial, 21 retrospective studies, and 14 prospective studies) fulfilled the inclusion criteria and were selected for meta-analysis ( Figure 1). Table 1 reports the features of the studies selected for quantitative analysis.…”

“…The number of patients treated with steroids varied greatly, ranging from 11 55 to 736. 6 Thirteen studies [24][25][26]28,32,34,35,[37][38][39]41,49,52,55 included fewer than 30 patients, with wide CIs resulting in inaccurate estimates of relapse rates. Twenty-two studies were performed in Asian countries, 11 and 12 were conducted in Western countries.…”

“…Twenty-two studies were performed in Asian countries, 11 and 12 were conducted in Western countries. 5,12,28,30,31,35,38,43,46,51,54,55 Two were multinational studies. 6,40 Twenty-three studies were conducted at single centers.…”

“…6,40 Twenty-three studies were conducted at single centers. [24][25][26][27][28][29][30]33,35,[37][38][39]42,[49][50][51][52][53][54][55] Thirteen studies were multicentric. 6,9,11,12,31,34,36,40,41,[45][46][47][48] In 8 studies 12,24,[32][33][34]36,44,50 relapse was defined radiologically, whereas in 17 studies 9,[27][28][29][30][31]35,[39][40]<...>…”

“…Relapse was not clearly defined in 11 studies (including 4 abstracts). 6,11,25,26,37,38,43,[51][52][53]55 In 16 studies 9,11,[24][25][26]29,32,37,39,41,44,45,47,48,50,55 MST lasted more than 1 year (long-term maintenance). In 13 studies 12,27,28,30,31,33,35,36,38,42,43,46,49 MST was shorter than 1 year (short-term maintenance).…”