Autoimmune Pancreatitis: The Emerging Role of Serologic Biomarkers

Wiley, John W.; Pietropaolo, Massimo

doi:10.2337/db08-1655

Cited by 8 publications

(2 citation statements)

References 16 publications

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“…A research team in Japan succeeded in inducing AIP in newborn athymic mice by immunising them with lactoferrin and CAII [30] . Another research group detected antibodies against amylase α2 in AIP [31] . None of the reported markers are so specific that they can discriminate safely between AIP and PaCa.…”

Section: Discussionmentioning

confidence: 99%

Serum Protein Signatures Differentiating Autoimmune Pancreatitis versus Pancreatic Cancer

Felix

Fritz

et al. 2013

PLoS ONE

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Autoimmune pancreatitis (AIP) is defined by characteristic lymphoplasmacytic infiltrate, ductal strictures and a pancreatic enlargement or mass that can mimic pancreatic cancer (PaCa). The distinction between this benign disease and pancreatic cancer can be challenging. However, an accurate diagnosis may pre-empt the misdiagnosis of cancer, allowing the appropriate medical treatment of AIP and, consequently, decreasing the number of unnecessary pancreatic resections.Mass spectrometry (MS) and two-dimensional differential gel electrophoresis (2D-DIGE) have been applied to analyse serum protein alterations associated with AIP and PaCa, and to identify protein signatures indicative of the diseases. Patients' sera were immunodepleted from the 20 most prominent serum proteins prior to further 2D-DIGE and image analysis. The identity of the most-discriminatory proteins detected, was performed by MS and ELISAs were applied to confirm their expression. Serum profiling data analysis with 2D-DIGE revealed 39 protein peaks able to discriminate between AIP and PaCa. Proteins were purified and further analysed by MALDI-TOF-MS. Peptide mass fingerprinting led to identification of eleven proteins. Among them apolipoprotein A-I, apolipoprotein A-II, transthyretin, and tetranectin were identified and found as 3.0-, 3.5-, 2-, and 1.6-fold decreased in PaCa sera, respectively, whereas haptoglobin and apolipoprotein E were found to be 3.8- and 1.6-fold elevated in PaCa sera. With the exception of haptoglobin the ELISA results of the identified proteins confirmed the 2D-DIGE image analysis characteristics. Integration of the identified serum proteins as AIP markers may have considerable potential to provide additional information for the diagnosis of AIP to choose the appropriate treatment.

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Section: Discussionmentioning

confidence: 99%

Serum Protein Signatures Differentiating Autoimmune Pancreatitis versus Pancreatic Cancer

Felix

Fritz

et al. 2013

PLoS ONE

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“…Several studies have noted antibodies to amylase in AIP patients. Wiley and Pietropaolo [ 70 ] note that autoantibodies and autoreactive T cells in CD-28-deficient NOD mice (which develop AIP) recognized pancreatic amylase. Another study found that the administration of tolerogenic amylase-coupled fixed spleen cells reduced the severity of the disease [ 71 ].…”

Section: Pathogenesis Of Aip: the Role Of Autoantibodiesmentioning

confidence: 99%

Autoantibodies in Autoimmune Pancreatitis

Smyk

Rigopoulou

Κουτσουμπασ

et al. 2012

International Journal of Rheumatology

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Autoimmune pancreatitis (AIP) was first used to describe cases of pancreatitis with narrowing of the pancreatic duct, enlargement of the pancreas, hyper-γ-globulinaemia, and antinuclear antibody (ANA) positivity serologically. The main differential diagnosis, is pancreatic cancer, which can be ruled out through radiological, serological, and histological investigations. The targets of ANA in patients with autoimmune pancreatitis do not appear to be similar to those found in other rheumatological diseases, as dsDNA, SS-A, and SS-B are not frequently recognized by AIP-related ANA. Other disease-specific autoantibodies, such as, antimitochondrial, antineutrophil cytoplasmic antibodies or diabetes-specific autoantibodies are virtually absent. Further studies have focused on the identification of pancreas-specific autoantigens and reported significant reactivity to lactoferrin, carbonic anhydrase, pancreas secretory trypsin inhibitor, amylase-alpha, heat-shock protein, and plasminogen-binding protein. This paper discusses the findings of these investigations and their relevance to the diagnosis, management, and pathogenesis of autoimmune pancreatitis.

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Biomarkers of acute and chronic pancreatitis

Kaphalia¹

2014

Biomarkers in Toxicology

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Autoimmune Pancreatitis: The Emerging Role of Serologic Biomarkers

Cited by 8 publications

References 16 publications

Serum Protein Signatures Differentiating Autoimmune Pancreatitis versus Pancreatic Cancer

Serum Protein Signatures Differentiating Autoimmune Pancreatitis versus Pancreatic Cancer

Autoantibodies in Autoimmune Pancreatitis

Biomarkers of acute and chronic pancreatitis

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