2014
DOI: 10.1016/j.autrev.2014.01.003
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Autoimmune primary ovarian insufficiency

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Cited by 175 publications
(155 citation statements)
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“…Currently, the histopathological analysis of the ovary is the only way to definitively diagnose autoimmune oophoritis, although due to general inaccessibility of the ovaries, this is often not attainable. 17,18 Instead, the majority of women with POI are diagnosed based on presence of antibodies reactive against ovarian tissue. Further, autoimmune POI is almost always associated with autoimmunity against other organs, in particular, autoimmune Addison's disease and the presence of serum autoantibodies targeting the adrenal gland.…”
Section: Autoimmune Oophoritis As a Cause For Primary Ovarian Insuffimentioning
confidence: 99%
“…Currently, the histopathological analysis of the ovary is the only way to definitively diagnose autoimmune oophoritis, although due to general inaccessibility of the ovaries, this is often not attainable. 17,18 Instead, the majority of women with POI are diagnosed based on presence of antibodies reactive against ovarian tissue. Further, autoimmune POI is almost always associated with autoimmunity against other organs, in particular, autoimmune Addison's disease and the presence of serum autoantibodies targeting the adrenal gland.…”
Section: Autoimmune Oophoritis As a Cause For Primary Ovarian Insuffimentioning
confidence: 99%
“…Some genetic mutations and disorders of the endocrine system can accelerate or modulate the rate at which the ovarian reserve is exhausted and cause premature ovarian insufficiency (POI) (1). Among the various causes of DOR, abnormal immune function may be a great contributor to this phenomenon (2). Patients with DOR often become infertile and have a poor response to in vitro fertilization (IVF) (3,4).…”
Section: Introductionmentioning
confidence: 99%
“…In contrast, testing for ovarian autoantibodies is currently thought to be of limited diagnostic value as although they are found in around 50% of patients with POI, they also have a high prevalence in controls (31%) [34]. The presence of many other autoantibodies has been investigated; however, reliable markers to diagnose non-adrenal autoimmunity are yet to be identified [32].Approximately 10-30% of women with POI may suffer from additional autoimmune disorders including hypothyroidism (25%), diabetes mellitus (2.5%), systemic lupus erythematosus, pernicious anemia, vitiligo and rheumatoid arthritis among others. Autoantibodies most commonly occur in association with Addison's disease, as part of one of two types of autoimmune polyendocrine syndromes (APS Types 1 and 2).…”
mentioning
confidence: 99%
“…Adrenal autoimmunity is thought to account for 60-80% of autoimmune POI [32] and there is a strong association between the presence of adrenal antibodies and a diagnosis of autoimmune lymphocytic oophoritis [33]. In contrast, testing for ovarian autoantibodies is currently thought to be of limited diagnostic value as although they are found in around 50% of patients with POI, they also have a high prevalence in controls (31%) [34].…”
mentioning
confidence: 99%
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