Autoimmune progesterone dermatitis in a parturient for emergency caesarean section

Autoimmune progesterone dermatitis associated with infertility treatment

“…4,5 In our patient's case, the risk of anaphylaxis was felt to be lower given her moderate eczematous presentation and previously demonstrated response to topical corticosteroids, and the choice was made to proceed with in vitro fertilization with continued close dermatologic follow-up. One should be cautious when considering infertility treatment in a patient with a history of urticarial AIPD because there may be a true, though rare, association with anaphylaxis.…”

Urticaria and Angioedema in Pregnancy

“…In one case report, progesterone dermatitis was induced by a metabolite of progesterone that was used as supplementation during pregnancy to prevent preterm birth [24]. In another case report, progesterone dermatitis became aggravated during the third trimester of pregnancy, necessitating high doses of steroids [25].…”

Autoimmune Progesterone Dermatitis: Potential Role of Cutaneous Angiogenin Expression?

“…We describe a patient with features typical of autoimmune progesterone dermatitis (AIPD), a rare polymorphous menstrualcycle-related dermatosis [1][2][3][4][5][6] . To gain better insight into the pathogenesis of this peculiar entity, we here carried out skin testing for hypersensitivity to progesterone as well as a cytokine array study using nonlesional and lesional skin obtained during a flare of her skin disease.…”

“…Estroprogestative contraception is the most commonly used therapy [1,2,5,7,26] . Other treatments include danazol [27] , a synthetic steroid analog that inhibits LH and FSH surge, azathioprin [5] , tamoxifen [9,28] as well as oophorectomy [4,6,14] . However, LH-RH analogs which induce reversible menopause are often preferred [1,29] .…”

“…AIPD is a rare but characteristic entity, of which at least 70 cases have been described so far [1] . Its clinical presentation is extremely variable with erythematous, macular, papular and/or vesicular rashes [7][8][9] , palmoplantar dyshidrosis [2, 10] , erythemamultiforme-like lesion [2-4, 11, 12] , stomatitis [9] as well as urticaria [13,14] , angioedema [6] and anaphylactic-like shock [7,10,15] . The lesions typically and constantly relapse during the luteal phase of the menstrual cycle.…”