Autoimmune Progesterone Dermatitis: Potential Role of Cutaneous Angiogenin Expression?

Poffet, F.; Abraham, Susamma; Taramarcaz, Philip; Fontao, Lionel; Borradori, Luca

doi:10.1159/000329427

Cited by 9 publications

(11 citation statements)

References 27 publications

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“…The pathogenesis of APD is not entirely clear. Intradermal test results to progesterone can produce both type 1 and type 4 hypersensitivity reactions …”

Section: Autoimmune Progesterone Dermatitis and Oestrogen Dermatitismentioning

confidence: 99%

The menstrual cycle and the skin

2015

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Perimenstrual exacerbations of dermatoses are commonly recognized, yet our knowledge of the underlying pathophysiological mechanisms remains imperfect. Research into the effects of oestrogen on the skin has provided evidence to suggest that oestrogen is associated with increases in skin thickness and dermal water content, improved barrier function, and enhanced wound healing. Research into the effects of progesterone suggests that the presence of various dermatoses correlates with peak levels of progesterone. Dermatoses that are exacerbated perimenstrually include acne, psoriasis, atopic eczema and irritant dermatitis, and possibly also erythema multiforme. Exacerbations occur at the peak levels of progesterone in the menstrual cycle. Underlying mechanisms include reduced immune and barrier functions as a result of cyclical fluctuations in oestrogen and/or progesterone. Autoimmune progesterone and oestrogen dermatitis are the best-characterized examples of perimenstrual cutaneous reactions to hormones produced during the menstrual cycle. In this review, we describe the current understanding of the menstrual cycle, and its effect on the skin and cutaneous disorders.

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“…The pathogenesis of APD is not entirely clear. Intradermal test results to progesterone can produce both type 1 and type 4 hypersensitivity reactions …”

Section: Autoimmune Progesterone Dermatitis and Oestrogen Dermatitismentioning

confidence: 99%

The menstrual cycle and the skin

2015

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show abstract

“…[5] Due to its rarity, APD should be considered a diagnosis of exclusion. [6][7][8][9] In this case, we believe symptoms occurred as a result of increased hypersensitivity to endogenous progesterone, triggered immediately after medical abortion.…”

mentioning

confidence: 75%

“…[8,9,17] Pregnancy may either worsen or improve the condition. [6,9] APD symptoms range from minor to severe skin presentations to severe systemic complications such as symptoms of asthma or anaphylaxis .…”

Section: Discussionmentioning

confidence: 99%

“…[8,31] Though reported to be used by many clinicians, tamoxifen has shown to be associated with symptoms of oestrogen deficiency and increased risk of venous thrombosis and cataract formation. Extra monitoring is important if it is given to patients with high risk.…”

Section: Discussionmentioning

confidence: 99%

“…Extra monitoring is important if it is given to patients with high risk. [6,8,31] Surgery has been used in some severe cases of APD. This line of management is usually taken after medical options have failed.…”

Section: Discussionmentioning

confidence: 99%

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