Autoimmune thyroid disease and antiphospholipid antibodies

Nabriski, Dan; Ellis, Martin; Ness‐Abramof, Rosanne; Shapiro, Mia; Shenkman, Louis

doi:10.1002/(sici)1096-8652(200005)64:1<73::aid-ajh14>3.3.co;2-l

Cited by 15 publications

(21 citation statements)

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“…31 32 These findings support the notion that nonspecific autoantibody production, secondary to 'overstimulation' of autoreactive B cell clones, may accompany the synthesis of thyroid-specific immunoglobulin in autoimmune disease. 31 Therefore patients with ATD need not be examined routinely for the presence of aPL. Primary Sjögren's syndrome (pSS) is an autoimmune exocrine disorder characterized by lymphoid infiltration and functional deterioration of the exocrine glands, especially the lacrymal and salivary glands, and by B cell hyper-responsiveness and an increase of antibodies against nuclear antigens, including SS-A and SS-B.…”

Section: Adrenalsupporting

confidence: 70%

“…In contrast, Petri and coworkers were unable to replicate these results in a cohort of patients with Graves' disease and Hashimoto's thyoiditis and concluded that aPL is no more common in ATD than in healthy individuals. 28 31 It was concluded that the prevalence of aPL in ATD is increased compared to healthy individuals but that this is likely to be an epiphenomenon. 31 32 These findings support the notion that nonspecific autoantibody production, secondary to 'overstimulation' of autoreactive B cell clones, may accompany the synthesis of thyroid-specific immunoglobulin in autoimmune disease.…”

Section: Adrenalmentioning

confidence: 99%

“…28 31 It was concluded that the prevalence of aPL in ATD is increased compared to healthy individuals but that this is likely to be an epiphenomenon. 31 32 These findings support the notion that nonspecific autoantibody production, secondary to 'overstimulation' of autoreactive B cell clones, may accompany the synthesis of thyroid-specific immunoglobulin in autoimmune disease. 31 Therefore patients with ATD need not be examined routinely for the presence of aPL.…”

Section: Adrenalmentioning

confidence: 99%

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Endocrinologic Manifestations of the Antiphospholipid Syndrome

Uthman

Salti

Khamashta

2006

Lupus

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Our objective was to study the endocrinologic manifestations of the antiphospholipid syndrome (APS). We reviewed the medical literature from 1968 until 2005 using MEDLINE and the key words: APS, anticardiolipin antibodies, lupus anticoagulant, antiphospholipid antibodies, adrenal, thyroid, parathyroid, pituitary, diabetes, ovaries and testes. Adrenal insufficiency is the most common endocrinologic manifestation and can be the presenting symptom of APS. In patients with autoimmune thyroid disease circulating aPL have been detected. However, no clinical manifestations of APS have been described. A few cases of hypopituitarism have been reported, including a case of Sheehan's syndrome. aPL has been detected in the sera of diabetic patients, probably associated with some macroangiopathic complications. Finally only very few cases of ovarian and testicular involvement have been reported. The adrenals are the most commonly involved glands in the APS. Clinicians should keep a high index of suspicion for adrenal insufficiency in patients with APS.

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Section: Adrenalsupporting

confidence: 70%

Section: Adrenalmentioning

confidence: 99%

Section: Adrenalmentioning

confidence: 99%

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Endocrinologic Manifestations of the Antiphospholipid Syndrome

Uthman

Salti

Khamashta

2006

Lupus

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“…Although some preliminary data report an increased prevalence of anticardiolipin antibodies in patients with ATD [25], the prevalence of ATA in the setting of the antiphospholipid syndrome (APS), either primary or secondary, is not known so far. Conflicting is also the data in patients with scleroderma [21,22].…”

Section: Lesson 1: Antithyroid Antibodies Are Fre-quent In Limited Scmentioning

confidence: 99%

Systemic Autoimmune Manifestations: When Should Underlying Thyroid Autoimmunity be Considered?

Mavragani¹,

Danielides²,

Moutsopoulos

2006

CRR

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Autoimmune thyroid disease is among the most common autoimmune disorders affecting 10% of the population. It is characterized by diffuse lymphocytic infiltration of the thyroid gland, the presence of antithyroid antibodies and diffuse hypoechogenicity on thyroid ultrasound. Despite the fact that autoimmune thyroid disease is classically considered a localized disease of the thyroid gland, systemic features, such as musculoskeletal complaints, sicca symptomatology, pregnancy loss and even neurological manifestations are not uncommon. Although thyroid dysfunction could account for some of these features, concomitant autoimmune disorders or even thyroid autoimmunity itself could be involved. In the current report new clinical and laboratory data from our department are presented and the existing literature regarding the systemic/rheumatic features of autoimmune thyroid disease is reviewed.

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“…[21][22][23] Although patients with TAI seem more prone to produce several auto-Ab, the presence of aLN-1 was not yet investigated in infertile women with HT.…”

Section: Introductionmentioning

confidence: 99%

Anti-laminin-1 antibodies in serum and follicular fluid of women with Hashimoto’s thyroiditis undergoing in vitro fertilization

Caccavo

Pellegrino

Nardelli

et al. 2016

Int J Immunopathol Pharmacol

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The aim of this study is to evaluate the presence of anti-laminin-1 antibodies (aLN-1) in sera and follicular fluid (FF) of infertile women affected by Hashimoto's thyroiditis (HT) undergoing in vitro fertilization (IVF) and its impact on oocyte maturation and IVF outcome. aLN-1 were measured by a home-made enzyme linked immunosorbent assay (ELISA) in: (1) sera and FF from 44 infertile women affected by HT (HTIW) with tubal factor or male factor as primary cause of infertility; (2) in sera and FF from 28 infertile women without HT, with tubal factor or male factor as cause of infertility (infertile controls-ICTR); and (3) in sera from 50 fertile women (FW). aLN-1 serum levels were significantly higher in HTIW when compared with both fertile women and ICTR (P <0.001and P <0.01, respectively). Assuming as cutoff the 99th percentile of values obtained in sera of FW, 43.2% of HTIW and 3.6% of ICTR were aLN-1 positive (P = 0.0001). Also aLN-1 detected in FF from HTIW were significantly higher in comparison with those found in FF of ICTR (P = 0.006). In HTIW, metaphase II oocyte count showed inverse correlation with both serum and FF aLN-1 levels (r = 0.34, P = 0.02 and r = 0.33, P = 0.03, respectively). Implantation and pregnancy rates were significantly lower in HTIW (7.9% and 9.1%, respectively) when compared with ICTR (23% and 31.1%, respectively) (P = 0.015 and P = 0.03, respectively). Our results demonstrated for the first time the presence of aLN-1 in a relevant percentage of HTIW and suggest that these auto-antibodies may impair IVF outcome.

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Autoimmune thyroid disease and antiphospholipid antibodies

Cited by 15 publications

References 0 publications

Endocrinologic Manifestations of the Antiphospholipid Syndrome

Endocrinologic Manifestations of the Antiphospholipid Syndrome

Systemic Autoimmune Manifestations: When Should Underlying Thyroid Autoimmunity be Considered?

Anti-laminin-1 antibodies in serum and follicular fluid of women with Hashimoto’s thyroiditis undergoing in vitro fertilization

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