Autoimmune Thyroid Disease and Celiac Disease in Children

Ansaldi, N; Palmas, T.; Corrias, Andrea; Barbato, M.; D'Altiglia, Mario Rocco; Campanozzi, Angelo; Martire, Baldassarre; Rea, Francesco; R, Pluvio; Bonamico, Margherita; Lazzari, R; Corrao, Giovanni

doi:10.1097/00005176-200307000-00010

Cited by 95 publications

(81 citation statements)

References 11 publications

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“…However, intestinal biopsy is still the gold standard in the diagnosis of the disease (24). It has been reported in numerous previous studies that the prevalence of autoimmune thyroid disease is increased in individuals with celiac disease (25)(26)(27). However, there are a limited number of studies examining the prevalence of CD in children and adolescents with autoimmune thyroid disease.…”

Section: Discussionmentioning

confidence: 99%

Celiac disease in children and adolescents with Hashimoto Thyroiditis

et al. 2016

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Aim: The aim of this study was to evaluate clinical and laboratory findings and determine the prevalence of celiac disease (CD) in children with Hashimoto thyroiditis (HT). Material and Methods:The data of a total of 80 patients with positive anti-thyroid antibodies who were aged between 6 and 17.9 years were retrospectively studied. Age, gender, complaints at the time of presentation, family history of thyroid disorders, clinical and laboratory findings were recorded. The levels of thyrotropin, free thyroxin, thyroid autoantibodies (thyroid peroxidase and thyroglobulin antibodies), immunoglobulin A (IgA), anti-tissue transglutaminase antibodies (IgA-tTG), and thyroid ultrasonography findings were enrolled.Results: Eighty patients (65 females (81.2%) and 15 males (18,8%)) were included in the study. Family history of thyroid disease was present in 38 (47.5%) patients. The most common complaints at the time of presentation were goiter (%30) and weight gain (%25). Forty three (53.8%), 23 (28.7%), and 14 (17.5%) patients presented with euthyroidism, subclinical hypothyroidism and obvious hypothyroidism. Thirty seven (46.2%) patients had goiter. IgA-tTG was found to be positive after a diagnosis of HT was made in only one patient (1.25%) and the diagnosis of CD was confirmed when intestinal biopsy of this patient revealed villus atrophy, crypt hyperplasia and increase in the intraepithelial lymphocyte count. Conclusions:In our study, it was found that the most common complaints at presentation in patients with a diagnosis of hashimoto thyroiditis included goiter, weakness and weight gain and the prevalence of celiac diseases was found to be 1.25% (1/80). This study shows that the prevalence of CD in patients with a diagnosis of HT is higher compared to the prevalence in the healthy pediatric population.

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Section: Discussionmentioning

confidence: 99%

Celiac disease in children and adolescents with Hashimoto Thyroiditis

et al. 2016

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“…In both phases of this study a high prevalence to anti-ATM in relatives (P = 0.0050; P = 0.0117), followed for anti-PCA (P = 0.0473; P = 0.0635) was observed in CD relatives when compared with the control group. Ansaldi et al (2) showed that 26% of Italian CD patients had positive autoimmune thyroid serology compared to 10% in the control subjects. Ventura el al.…”

Section: Discussionmentioning

confidence: 99%

“…However, in this study, (1) Group > 60 years phase II x 0-18 years and 19-60 years phase II: P = 0.083 Chi-square with Yates' correction FIGURE 2. Positivity to autoantibodies in relatives of phases I and II in relation to age (1) Parents phase II x siblings phase II: P = 0.0356 (2) Parents phase II x offsprings phase II: P = 0.002 Fisher FIGURE 1. Positivity of autoantibodies in relatives of phases I and II in relation to parentage one female 52 years old, that was amongst the five relatives positive to anti-PCA in phase II (Table 2), had clinical and endoscopic diagnosis of auto-immune gastritis, while the others relatives still await for the results.…”

Section: Discussionmentioning

confidence: 99%

Autoantibodies in relatives of celiac disease patients: a follow-up of 6-10 years

Nass

Kotze

Nisihara

et al. 2012

Arq. Gastroenterol.

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-Context -Autoimmune diseases are 3 to 10 times more frequently in patients with celiac disease and their relatives than in the general population. Objective -To investigate a broad spectrum of autoantibodies in celiac disease relatives from Southern Brazil, in a serological follow-up of 6-10 years, aiming to associate with other autoimmune diseases, degree of parentage, demographic and clinical data. Methods -Serum samples of 233 relatives were analyzed in two different phases: n = 186 in phase I (1997)(1998)(1999)(2000) and n = 138 (being 91 = follow-up group and 47 = newly tested) in phase II (2006II ( -2007. As controls, 100 unrelated individuals were evaluated. Autoantibodies to smooth muscle, mitochondrial, liver-kidney microssome, parietal cell and thyroid microssome were tested by indirect immunofluorescence. Results -A significant increase of autoantibodies, in both phases, was observed in the relatives when compared to the non-relatives (P = 0.0064), specifically to anti-thyroid microssome and anti-parietal cell. In both phases, the female/male proportion of autoantibodies was of 4:1 to 3:1 (P≤0.041). The frequency of autoantibodies amongst 1st and 2nd degree relatives was 11.8% and 9.68% in phase I and 4% and 6.67% in phase II. Conclusion -Celiac disease relatives presented other autoantibodies and serological screening is a useful instrument for identifying autoimmune diseases along the years.

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“…Autoimmune thyroid disease was found in 90 (26.2%) of the CD patients, even those on a gluten free diet. This high prevalence points the importance of thyroid status assessment at diagnosis and at follow up evaluation in children with CD [56]. Meloni at al.…”

Section: Clinical Manifestationsmentioning

confidence: 97%

Hashimoto Thyroiditis in Childhood – Review of the Epidemiology, Genetic Susceptibility and Clinical Aspects of the Disease

Zdraveska

Kočova

2012

Maced J Med Sci

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Chronic autoimmune thyroiditis or Hashimoto's thyroiditis (HT) is the most common cause of thyroid diseases in children and adolescents. It is also the most common cause of acquired hypothyroidism with or without goiter. The incidence of autoimmune thyroiditis has increased dramatically over the past few decades, affecting up to 5% of the general population in iodine sufficient areas. HT is caused by the complex interplay of genetic, environmental, and endogenous factors. Significant progress has been made in identifying and characterizing the genes involved in pathogenesis of the disease.The aim of this review is to analyze current opinions and options regarding the etiology, genetic contribution to the pathogenesis, evaluation, diagnosis, treatment, and prognosis of the HT in children.

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Autoimmune Thyroid Disease and Celiac Disease in Children

Abstract: The high frequency of autoimmune thyroid disease found among patients with CD, even those on a gluten-free diet, may justify a thyroid status assessment at diagnosis and at follow-up evaluation of children with CD.

Cited by 95 publications

References 11 publications

Celiac disease in children and adolescents with Hashimoto Thyroiditis

Celiac disease in children and adolescents with Hashimoto Thyroiditis

Autoantibodies in relatives of celiac disease patients: a follow-up of 6-10 years

Hashimoto Thyroiditis in Childhood – Review of the Epidemiology, Genetic Susceptibility and Clinical Aspects of the Disease

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