Autoimmune thyroid disease in Libyan children and young adults with type 1 diabetes mellitus

Ghawil, Millad; Tonutti, Elio; Abusrewil, S. S.; Visentini, Daniela; Hadeed, Ibtisam; Miotti, Valeria; Pecile, Paolo; Morgham, Amel; Tenore, Alfred

doi:10.1007/s00431-010-1386-1

Cited by 32 publications

(37 citation statements)

References 25 publications

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“…The prevalence reported and study sample size varied from one study to another study. The prevalence of subclinical hypothyroidism was reported as 2.3 times in adult population of Libya (Ghawil et al, 2011) compared with study conducted in Colorado documented that the prevalence of subclinical hypothyroid in the general population ranged between 4 and 10% (Canaris et al, 2000). So, our review suggested that the prevalence in Arab region is comparatively low.…”

Section: Discussionmentioning

confidence: 49%

“…The review results showed different study designs as follows: seven cross-sectional studies were conducted in different Arab regions, including Libya, Saud Arabia, Egypt, Algeria, Bahrain and Oman (El-Mougi et al, 2004;Ghawil et al, 2011;Henjum et al, 2010;Lamfon, 2008;Moosa et al, 2000;Nouh et al, 2008;Elbualy et al,1998). The sample size found varied from 99 to 749 subjects except for one study conducted in Oman in which 36000 babies were diagnosed.…”

Section: Methodsmentioning

confidence: 99%

“…The prevalence of different types of thyroid disease varied between the studies. The study conducted in 2011 in Libya reported the prevalence of subclinical hypothyroidism as 2.3% (Ghawil et al, 2011), and prevalence of hypothyroidism was reported as 6.18% in Libya (Nouh et al, 2008) and 47.34% in Saud Arabia (Makkah region) (Lamfon, 2008) and the prevalence of goiter was reported by many studies conducted in Egypt, Algeria and Bahrain (25.25, 86 and 1.7%, respectively) (El-Mougi et al, 2004;Henjum et al, 2010;Moosa et al, 2000).…”

Section: Prevalence Of Thyroid Lesionsmentioning

confidence: 99%

See 2 more Smart Citations

The epidemiology of thyroid diseases in the Arab world: A systematic review

Shahrani¹,

El-Metwally²,

Al-Surimi³

et al. 2016

J. Public Health Epidemiol.

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Thyroid gland diseases are a public health problem worldwide. Imbalance in the regulation of thyroid gland hormones can cause many disorders that range from a small goiter to life threatening diseases, such as thyroid cancer. Thyroid dysfunction both hyper and hypothyroidism can affect circulatory system by affecting cardiac output, cardiac contractility, blood pressure, vascular resistance and rhythm disturbance which can further cause heart failure, fibrillation, congestive heart failure and blood pressure. Westernization and nutrition transition in Arab world have increased the burden of adenocarcinomas, including thyroid cancer. This review aims to present the aggregated burden, risk factors and prognosis of various thyroid diseases prevalent in Arab countries. An electronic databases search was conducted using PubMed in addition to searching of accessible local journals in Arab world, using keywords and terms like epidemiology, burden, odds, risks, etc. After applying exclusion and inclusion criteria, 21 articles were selected to include in this review. The review showed that the prevalence of different types of thyroid disease varied between the reported studies in Arab world ranging from 6.18 to 47.34% prevalence of goiter reported by several studies conducted in Arab world, such as Egypt, Algeria and Bahrain with 25.25, 86 and 1.7%, respectively. Gender, dietary factors, iodine deficiency, family history, diabetes and x-ray radiation were reported as risk factors associated with different type of thyroid diseases. The most prevalence of thyroid disease was concluded to be thyroid lesions which varied in different regions of Arab and the burden of thyroid cancer is very high and very common in different Arab region, and further longitudinal studies are still needed to investigate the prognosis and determinants of these thyroid diseases in the Arab world.

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Section: Discussionmentioning

confidence: 49%

Section: Methodsmentioning

confidence: 99%

Section: Prevalence Of Thyroid Lesionsmentioning

confidence: 99%

See 1 more Smart Citation

The epidemiology of thyroid diseases in the Arab world: A systematic review

Shahrani¹,

El-Metwally²,

Al-Surimi³

et al. 2016

J. Public Health Epidemiol.

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“…Thyroid autoimmunity is increased in females and with longer duration of diabetes (2,12,37,54). Prospective follow-up showed that the development of thyroid disease was related to the female gender and the presence of TPO antibodies, and measuring of circulating antibodies against thyroid peroxidase (anti-TPO Ab) and thyroglobolin (antiTg Ab) can be made easily (70).…”

Section: Discussionmentioning

confidence: 99%

“…Type one diabetes mellitus (T1DM) is an autoimmune disorder that is yet the most common type of diabetes in children and adolescents (1,2). This disorder results from immune and non-immune destruction of β-cell islets of the pancreas (3).…”

Section: Contextmentioning

confidence: 99%

Type 1 Diabetes Mellitus Associated With Autoimmune Thyroid Disorders in Iranian Children: A Review

Zamanfar¹,

Aarabi²,

Sadeghian³

2015

J Pediatr Rev

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Context: Type one diabetes mellitus (T1DM) is an autoimmune disorder that is yet the most common type of diabetes in children and adolescents. Several genetic risk factors have been associated with T1DM, auto immune thyroiditis and other autoimmune disorder. Among autoimmune disorders, autoimmune thyroid disease (ATD) is the most frequent disorder associated with T1DM. Its prevalence varies depending on age, sex and ethnic origin of the subjects and is considerably higher than the general population and increases with duration of T1DM. The aim of this study was to review the prevalence of ATD in Iranian children with T1DM compared with other countries. Evidence Acquisition: We conducted a review on all papers published on the association between autoimmune thyroiditis and T1DM, which was available on Google Scholar, Scientific Information Database (SID), Magiran and Iran Medex databases up to June 2014. Both Persian and English articles were checked. The searched terms were: diabetes mellitus, autoimmune thyroiditis, prevalence, frequency, Iranian children and adolescents. All papers which were done on patients with age under 20 years old and have used Anti-TPO and Anti-TG to evaluate patients were included. Results: Six papers met all the criteria. A total of 736 participants were included in this review. After review of all the papers, the prevalence of Anti-TPO was reported between 8% and 30% and Anti-TG was reported 6.06% to 23.6% in diabetic children in Iran. Conclusions: Autoimmune thyroid disorders are the most prevalent immunological diseases in patients with type 1 diabetes. All these studies have shown a higher prevalence of the disorder in patients with T1DM compared to the Iranian healthy population. Anti-TPO reported between 8% and 30% and Anti-TG reported 6.06% to 23.6% in diabetic children in Iran that was similar to the studies in other countries.

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Association between subclinical hypothyroidism and metabolic disorders: A retrospective chart review study in an emerging university hospital

Aldossari

Al-Ghamdi

Al-Zahrani

et al. 2019

Clinical Laboratory Analysis

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BackgroundSubclinical hypothyroidism is defined as an increase in serum levels of Thyroid Stimulating Hormone (TSH) above the normal range, without alteration of total T4 concentrations that is reported to have association with various metabolic conditions. The study aimed to investigate any association between subclinical hypothyroidism and metabolic disorders in Al Kharj city.MethodsThis is a cross‐sectional study that included review of patients’ charts from prince Sattam bin Abdul‐Aziz University, Al Kharj, Saudi Arabia, from August 1 to November 30, 2016. Data were analyzed with SPSS version 21. Descriptive statistics were obtained as frequencies. Pearson chi‐square analysis was used to assess any differences between disease status and study variables. P‐value < 0.05 was considered significant.ResultsThe mean age was 30.65 ± 13.3 with a female predominance. The average BMI was 29.5 ± 7.71; 46 (11.5%) had hypertension, 52 (46.8%) had diabetes, 173 (44%) had anemia, and 192 (56%) had vitamin D deficiency. Due to increased TSH levels, male gender had higher prevalence of subclinical hypothyroidism with P‐value < 0.001 and 0.011, respectively.ConclusionSubclinical hypothyroidism is a significant topic worldwide whose prevalence is rising. In this study, we could not find any significant association between subclinical hypothyroidism and metabolic disorder. Further longitudinal studies with large sample size are needed to study this association.

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Autoimmune thyroid disease in Libyan children and young adults with type 1 diabetes mellitus

Cited by 32 publications

References 25 publications

The epidemiology of thyroid diseases in the Arab world: A systematic review

The epidemiology of thyroid diseases in the Arab world: A systematic review

Type 1 Diabetes Mellitus Associated With Autoimmune Thyroid Disorders in Iranian Children: A Review

Association between subclinical hypothyroidism and metabolic disorders: A retrospective chart review study in an emerging university hospital

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