Autoinflammatory syndromes

Meier‐Schiesser, Barbara; French, Lars E.

doi:10.1111/ddg.14332

Cited by 9 publications

(9 citation statements)

References 109 publications

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“…pathway is also seen in other autoinflammatory diseases and syndromes [12]. In addition to overactivation of innate immunity, there is evidence of an antigen-driven process.…”

Section: Epidermotropism Of Inflammatory Cells Differentiates Pyoderm...mentioning

confidence: 95%

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Epidermotropism of inflammatory cells differentiates pyoderma gangrenosum from venous leg ulcers

Ronicke

Baur

Kirr

et al. 2022

J Deutsche Derma Gesell

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Summary Background and objectives Pyoderma gangrenosum is an ulcerative autoinflammatory disease, lacking distinct histopathological characteristics to differentiate from other ulcerating conditions, like venous leg ulcers. The objective of this study was therefore to find histopathological characteristics of pyoderma gangrenosum in a head‐to‐head comparison to venous leg ulcers. Patients and methods Eight tissue samples of pyoderma gangrenosum, twelve samples of venous leg ulcers and six samples of healthy skin were stained using an immunohistological multi antigen staining technology. The immune infiltrate and its spatial distribution were analyzed with contextual tissue cytometry software using fluorescence images. Results The dense epidermal presence of CD45RO+ memory T cells and the rarefication of CD1a+ Langerhans cells in the epidermis were defining markers for pyoderma gangrenosum, implicating an epidermal immune reaction. In addition, high numbers of CD11c+CD68+ pro‐inflammatory M1 macrophages were detected in the dermis, significantly extending the numbers seen in venous leg ulcers. Conclusions The histopathological differences found between pyoderma gangrenosum and venous leg ulcer can be used to distinguish between the two diseases and thus provide an important aid for the rapid initiation of adequate therapy. In addition, our data hint at an antigen‐driven process in the epidermis, possibly involving CD1a+ Langerhans cells.

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“…pathway is also seen in other autoinflammatory diseases and syndromes [12]. In addition to overactivation of innate immunity, there is evidence of an antigen-driven process.…”

Section: Epidermotropism Of Inflammatory Cells Differentiates Pyoderm...mentioning

confidence: 95%

“…This assumption is based on the fact that in syndromal forms of PG, mutations have been found in genes coding for proteins of the inflammasome [8]. This pathway is also seen in other autoinflammatory diseases and syndromes [12]. In addition to overactivation of innate immunity, there is evidence of an antigen‐driven process.…”

Section: Introductionmentioning

confidence: 99%

Epidermotropism of inflammatory cells differentiates pyoderma gangrenosum from venous leg ulcers

Ronicke

Baur

Kirr

et al. 2022

J Deutsche Derma Gesell

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“…Cytokines, such as TNFα, IL-1β, and IL-6, are involved in processes modulated by their delivery in extracellular vesicles 9,19,20 www.nature.com/scientificreports/ inflammasomes. Activation of the inflammasome leads to the cleavage of pro-interleukin (IL)-1β and the secretion of active IL-1β 21 . In addition, NF-κB and TNFα signaling are also activated in certain autoinflammatory diseases 19 .…”

Section: Esmentioning

confidence: 99%

Elevated G-CSF, IL8, and HGF in patients with definite Meniere’s disease may indicate the role of NET formation in triggering autoimmunity and autoinflammation

Zou

Zhao

Song

et al. 2022

Sci Rep

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The etiology and mechanism causing Meniere’s disease (MD) are not understood. The present study investigated the possible molecular mechanism of autoimmunity and autoinflammation associated with MD. Thirty-eight patients with definite MD and 39 normal volunteers were recruited, and 48 human cytokines/chemokines were quantified. In patients with MD pure tone audiograms, tympanograms and standard blood tests were performed. The mean hearing loss in the worse ear was 44.1 dB nHL. Compared to the referents, the concentrations of TNFα, IL1α, IL8, CTACK, MIP1α, MIP1β, G-CSF, and HGF in the sera of patients with MD were significantly elevated, while those of TRAIL and PDGFBB were significantly decreased. The area under the receiver operating characteristic curve (AUC) showed that G-CSF, MIP1α, and IL8 were above 0.8 and could be used to diagnose MD (p < 0.01), and the AUCs of CTACK and HGF were above 0.7 and acceptable to discriminate the MD group from the control group (p < 0.01). The revised AUCs (1 − AUC) of TRAIL and PDGFBB were above 0.7 and could also be used in the diagnosis of MD (p < 0.01). The linear regression showed significant correlations between MIP1α and GCSF, between IL2Rα and GCSF, between IL8 and HGF, between MIP1α and IL8, and between SCF and CTACK; there was a marginal linear association between IP10 and MIP1α. Linear regression also showed that there were significant age-related correlations of CTACK and MIG expression in the MD group (p < 0.01, ANOVA) but not in the control group. We hypothesize that G-CSF, IL8, and HGF, which are involved in the development of neutrophil extracellular traps (NETs) and through various mechanisms influence the functions of macrophages, lymphocytes, and dendritic cells, among others, are key players in the development of EH and MD and could be useful in elucidating the pathophysiological mechanisms leading to MD. Biomarkers identified in the present study may suggest that both autoimmune and autoinflammatory mechanisms are involved in MD. In the future, it will be valuable to develop a cost-effective method to detect G-CSF, IL8, HGF, CTACK, MIP1α, TRAIL, and PDGFBB in the serum of patient that have diagnostic relevance.

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“…Its excellency and wide-spread use are attributed to the absence of radiation, portability, dynamic examination, and low cost [2]. Numerous diseases overlap both dermatology and rheumatology and many can lead to arthritis of one or more joints [3][4][5]. One of the most frequent is psoriatic arthritis (PsA), occurring in about 30 % of psoriasis patients [6] with prevalence rates of 1.8-2.1 and 2.1-2.5 per 100,000 individuals, respectively [7].…”

Section: Introductionmentioning

confidence: 99%

Establishment and validation of a didactic musculoskeletal ultrasound course for dermatologists using an innovative handheld ultrasound system – the MUDE study (Musculoskeletal Ultrasound in Dermatology)

Grobelski

Recker

Theis

et al. 2021

J Deutsche Derma Gesell

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Summary Background In the early detection of arthritis, such as psoriatic arthritis, musculoskeletal ultrasound (MSUS) of painful joints plays an important role in diagnosis. Pathological findings can be missed during clinical examination, especially if conducted by physicians who are not trained. The objective of this study was to examine a pilot MSUS course designed specifically for dermatologists, the MUDE protocol. Methods To assess the degree of MSUS expertise of the participants, a questionnaire using SurveyMonkey® was completed before the course. The course concept covered only the most important ultrasound sections of all joints and focused on the detection of joint effusion and hyperperfusion. The course consisted of three modules and was carried out over six months. The portable Butterfly IQ® system in combination with an Apple iPad was provided to enable practice between the courses. The final teaching evaluation was carried out as an objective structured clinical examination (OSCE). Results Twelve dermatologists participated. The survey revealed no prior knowledge of MSUS. The overall score of all participants in the OSCE was 21.86 (87.44 %) out of a total of 25 points, which corresponded to the school grade good. Conclusion The innovative MUDE protocol is thus particularly suitable for the training of dermatologists in MSUS, irrespective of prior knowledge.

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Autoinflammatory syndromes

Cited by 9 publications

References 109 publications

Epidermotropism of inflammatory cells differentiates pyoderma gangrenosum from venous leg ulcers

Epidermotropism of inflammatory cells differentiates pyoderma gangrenosum from venous leg ulcers

Elevated G-CSF, IL8, and HGF in patients with definite Meniere’s disease may indicate the role of NET formation in triggering autoimmunity and autoinflammation

Establishment and validation of a didactic musculoskeletal ultrasound course for dermatologists using an innovative handheld ultrasound system – the MUDE study (Musculoskeletal Ultrasound in Dermatology)

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