Autologous “Blood Patch” Pleurodesis for Persistent Pulmonary Air Leak

Mallen, John K.; Landis, John N.; Frankel, Kenneth M.

doi:10.1378/chest.103.1.326-a

Cited by 18 publications

(17 citation statements)

References 1 publication

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“…Its mechanism of action is thought to be the direct sealing of the air leak by coagulated blood as well as functioning as a true pleurodesis (17,21) and it can be employed even if the lung is not fully expanded (18). Therefore, it is an easily applied treatment for pneumothorax, even in patients with less compliant lungs, such as seen in ILD.…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, it can contribute to the onset of acute exacerbation of idiopathic pulmonary fibrosis (14,15). As an alternative, autologous blood-patch pleurodesis has been used for the treatment of primary and secondary pneumothorax (16)(17)(18)(19)(20)(21). The injection of autologous blood into the pleural space is a simple, safe, and inexpensive treatment for pneumothorax and is available not only in patients with persistent air leak but also in those with residual air space (18).…”

Section: Introductionmentioning

confidence: 99%

“…As an alternative, autologous blood-patch pleurodesis has been used for the treatment of primary and secondary pneumothorax (16)(17)(18)(19)(20)(21). The injection of autologous blood into the pleural space is a simple, safe, and inexpensive treatment for pneumothorax and is available not only in patients with persistent air leak but also in those with residual air space (18). However, there have been no reports which have compared the efficacy and safety between the two methods of pleurodesis in patients with pneumothorax secondary to ILD.…”

Section: Introductionmentioning

confidence: 99%

“…However, since 2001, and based on previous reports (14,18,20), we have switched to using autologous blood-patch pleurodesis as first-line treatment in these patients. The aim of this study was to evaluate the efficacy and safety of autologous blood-patch pleurodesis in ILD patients.…”

Section: Introductionmentioning

confidence: 99%

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Efficacy of Blood-Patch Pleurodesis for Secondary Spontaneous Pneumothorax in Interstitial Lung Disease

et al. 2011

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Objective We identified the prognostic relevance of pneumothorax in interstitial lung disease (ILD) patients and evaluated the efficacy and safety of autologous blood-patch pleurodesis. Methods We retrospectively reviewed 59 occurrences of pneumothorax in 34 ILD patients identified over a 12-year period. Results Air leakage ceased in 16 of 22 (72.7%) episodes after blood pleurodesis and in 11 of 14 (78.6%) episodes after chemical pleurodesis. Both the cure ratio and recurrence ratio in the cure episodes were comparable with those in the chemical pleurodesis group (p=0.99 and 0.99, respectively). In addition, there were no harmful events associated with blood pleurodesis. The median survival time after the first episode of pneumothorax was less than 9 months in patients with idiopathic interstitial pneumonia (IIP) and only around 3 years in the patients with other types of ILD, which have essentially favorable outcomes. Kaplan-Meier survival estimates were significantly worse in the patients with concomitant pneumomediastinum than in those without (p<0.05). A multivariate Cox regression analysis identified that the number of episodes of pneumothorax, IIP diagnosis and concomitant pneumomediastinum were independent predictors of death. Conclusion Autologous blood-patch pleurodesis is safe and worth considering as a first-line treatment for pneumothorax secondary to ILD. However, despite treatments, the prognosis after the onset of pneumothorax in ILD patients was found to be poor. In addition, concomitant pneumomediastinum may further worsen the prognosis.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Efficacy of Blood-Patch Pleurodesis for Secondary Spontaneous Pneumothorax in Interstitial Lung Disease

et al. 2011

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“…Then, Dumire et al [7] reported its use after pulmonary lobectomy, with immediate success. Since 1992, there have been very few reports on the beneficial use of autologous blood for sealing persistent air leaks either in patients with spontaneous pneumothorax or after pulmonary resections [8][9][10][11][12].…”

Section: Introductionmentioning

confidence: 99%