Autologous bone marrow-derived mesenchymal stem cells provide complete regeneration in a rabbit model of the Achilles tendon bundle rupture

Chailakhyan, R. K.; Kon, Elizaveta; Shekhter, Anatoly B.; Ivannikov, S. V.; Tel’pukhov, V. I.; Grosheva, A. G.; Suslin, D S; Vorobieva, N. N.; Gerasimov, Yury V.; Churbanov, Semyon; Kotova, Svetlana; Fayzullin, Alexey; Лычагин, А.В.; Lipina, Marina; Timashev, Peter

doi:10.1007/s00264-021-05168-1

Cited by 10 publications

(6 citation statements)

References 40 publications

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“…Nevertheless, due to their higher proliferative capacity and easier accessibility for tissue harvesting, ADSCs are also increasingly being used to facilitate tendon regeneration, increasing the number of cells available for clinical usage ( Torres-Torrillas et al, 2019 ). In a recent study, scaffolds loaded with and without autologous BMSCs were implanted into adult rabbit models of AT injury ( Chailakhyan et al, 2021 ). The BMSC-loaded scaffold group developed spindle-shaped tenocytes, neovascularization, and parallel collagen fibers 6 months after surgery.…”

Section: Tissue Regeneration Strategies For Achilles Tendon Injury Tr...mentioning

confidence: 99%

Advanced Nanofiber-Based Scaffolds for Achilles Tendon Regenerative Engineering

Zhu

He²,

Ji³

et al. 2022

Front. Bioeng. Biotechnol.

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The Achilles tendon (AT) is responsible for running, jumping, and standing. The AT injuries are very common in the population. In the adult population (21–60 years), the incidence of AT injuries is approximately 2.35 per 1,000 people. It negatively impacts people’s quality of life and increases the medical burden. Due to its low cellularity and vascular deficiency, AT has a poor healing ability. Therefore, AT injury healing has attracted a lot of attention from researchers. Current AT injury treatment options cannot effectively restore the mechanical structure and function of AT, which promotes the development of AT regenerative tissue engineering. Various nanofiber-based scaffolds are currently being explored due to their structural similarity to natural tendon and their ability to promote tissue regeneration. This review discusses current methods of AT regeneration, recent advances in the fabrication and enhancement of nanofiber-based scaffolds, and the development and use of multiscale nanofiber-based scaffolds for AT regeneration.

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Section: Tissue Regeneration Strategies For Achilles Tendon Injury Tr...mentioning

confidence: 99%

Advanced Nanofiber-Based Scaffolds for Achilles Tendon Regenerative Engineering

Zhu

He²,

Ji³

et al. 2022

Front. Bioeng. Biotechnol.

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“…Yang et al developed engineered tenogenesis TSCs admixed with scaffolds such as chitosan/β-glycerophosphate/collagen hydrogel in a rat AT model [ 146 ]. Autologous BM-MSCs loaded with collagen sponge in a vicryl mesh tube exhibited organized collagen fibers, neovasculogenesis, and spindle-shaped tenocytes with complete regeneration of tendons in a rabbit model Achilles tendon rupture [ 147 ]. In a rat model of Achilles tendon defects, seeding of hypoxia preconditioned AD-MSCs on small intestine submucosa (SIS) reported superior healing than cell-free SIS [ 148 ].…”

Section: Future Prospects In Atmentioning

confidence: 99%

Application of Orthobiologics in Achilles Tendinopathy: A Review

Ramires

Jeyaraman

Muthu

et al. 2022

Life

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Orthobiologics are biological materials that are intended for the regeneration of bone, cartilage, and soft tissues. In this review, we discuss the application of orthobiologics in Achilles tendinopathy, more specifically. We explain the concepts and definitions of each orthobiologic and the literature regarding its use in tendon disorders. The biological potential of these materials can be harnessed and administered into injured tissues, particularly in areas where standard healing is disrupted, a typical feature of Achilles tendinopathy. These products contain a wide variety of cell populations, cytokines, and growth factors, which have been shown to modulate many other cells at local and distal sites in the body. Collectively, they can shift the state of escalated inflammation and degeneration to reestablish tissue homeostasis. The typical features of Achilles tendinopathy are failed healing responses, persistent inflammation, and predominant catabolic reactions. Therefore, the application of orthobiologic tools represents a viable solution, considering their demonstrated efficacy, safety, and relatively easy manipulation. Perhaps a synergistic approach regarding the combination of these orthobiologics may promote more significant clinical outcomes rather than individual application. Although numerous optimistic results have been registered in the literature, additional studies and clinical trials are still highly desired to further illuminate the clinical utility and efficacy of these therapeutic strategies in the management of tendinopathies.

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“…Current research cell therapy with adipose-derived stem cells (ADSCs) shows excellent results in animal models (Arnaud-Franco et al 2022; Chailakhyan et al 2021;Shen et al 2020). However, the clinical approach in humans is still not well understood.…”

Section: Introductionmentioning

confidence: 99%

Effect of Cell Therapy With Adipose-Derived Stem Cells in the Treatment of Acute Rupture of the Achilles Tendon in Humans

Vieira,

Schweich-Adami,

Oliveira

et al. 2024

Preprint

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The aim of this study was to evaluate the effect of adipose-derived stem cells (ADSCs) in the treatment of acute rupture of the Achilles tendon. It was a cross-sectional study involving 15 patients. Patients were randomly divided: group 1 - rupture; group 2 – suture; group 3 – rupture + ADSCs. In the AOFAS score, the score was higher in group 3 with a significant difference. In the ATRS score, the score was higher in groups 2 and 3, also with a significant difference. As for the ultrasound score, there was a significant difference between the experimental groups in relation to this score, however, in the multiple comparisons test, comparing two groups at a time, it was possible to observe a significant difference of the experimental groups. It can be concluded that cell therapy in this condition may be a treatment option due to tissue regeneration and significant recovery of function.

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Autologous bone marrow-derived mesenchymal stem cells provide complete regeneration in a rabbit model of the Achilles tendon bundle rupture

Cited by 10 publications

References 40 publications

Advanced Nanofiber-Based Scaffolds for Achilles Tendon Regenerative Engineering

Advanced Nanofiber-Based Scaffolds for Achilles Tendon Regenerative Engineering

Application of Orthobiologics in Achilles Tendinopathy: A Review

Effect of Cell Therapy With Adipose-Derived Stem Cells in the Treatment of Acute Rupture of the Achilles Tendon in Humans

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