Autologous fat as a rectal–prostate spacer for prostate brachytherapy: Results at 6 months

Borghi, Marcelo; Becher, Ezequiel; Bou, Marcelo; de, Luis Montes; Long, Juan Fernandez; Rafailovici, Luisa; Filomia, Luisa; Becher, Edgardo

doi:10.1016/j.brachy.2019.04.001

Cited by 1 publication

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“…[ 10 ] Due to the limitations of the study conditions, none of our subjects used similar techniques, so the rectal volume of the PODT group and the PMRT group increased significantly, which was also significantly higher than the data reported in other studies. [ 11 ] It may be related to the fact that external radiation increases the target area of radiation therapy and increases the risk of rectal injury. [ 12 ] The outline of the PMRT group included the pelvic lymph node area, which greatly increased the irradiation dose of the bladder and bilateral femoral heads.…”

Section: Discussionmentioning

confidence: 99%

Treating the primary in low burden metastatic prostate cancer

Luo¹,

Fu²,

Wang³

et al. 2020

Medicine

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On the basis of endocrine therapy for patients with low burden metastatic prostate cancer (LBMP), the clinical efficacy and quality of life were compared between prostate-only directed radiotherapy (PODT) and prostate and metastasis radiotherapy (PMRT). From November 2009 to November 2015, total 91 patients newly diagnosed with LBMP were retrospectively analyzed, of which 52 patients received PODT and 39 patients received PMRT. The biochemical failure free interval (IBF), prostate specific survival (PCSS), and overall survival (OS) time were compared between the 2 groups, and expanded prostate cancer index composite (EPIC) scale was used to evaluate the difference in quality of life between the 2 groups. The median IBF of the PODT group was 31 months, which was significantly lower than the 39 months of the PMRT group ( P < .05); the 5-year OS and PCSS were 58.9%, 65.3% in PODT group, and 58.9%, 71.79% in PMRT group, respectively. There was no significant between the 2 groups ( P > .05); the side effects of acute radiotherapy in PMRT group were significantly higher than PODT group ( P < .05), especially in bone marrow suppression and gastrointestinal reactions; The scores of urinary system function and intestinal system function in PMRT group were significantly higher than PODT group at the end of radiotherapy, 3 months after radiotherapy, and 6 months after radiotherapy ( P < .05). The score of sexual function in PMRT group was significantly lower than that in PODT group after radiotherapy ( P < .05), and higher than that in PORT group at other follow-up time points ( P < .05). The hormone function was decreased at each follow-up time point in 2 groups, and there was no significant difference between the 2 groups ( P > .05). Patients with LBMP receiving PMRT can improve IBF, but cannot increase PCSS and OS, and increase the incidence of acute radiation injury.

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Section: Discussionmentioning

confidence: 99%