Autologous granulation tissue tubes for replacement of urethral defects: An experimental study in male rabbits

Jiang, Shiwei; Xu, Zhonghua; Zhao, Yuanyuan; Yan, Lei; Zhang, Zhou; Gu, Gang-Li

doi:10.1016/j.jpurol.2017.07.019

Cited by 2 publications

(1 citation statement)

References 21 publications

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“…For decades, the major challenges that urologists are eager to overcome include the injury and function loss of urinary tissue caused by congenital disorders, inflammation, tumor, trauma, and degenerative diseases ( Drewa et al, 2012 ; Zhang et al, 2020 ). For a long time, as a gold standard for clinical treatment, autologous tissue has played an important role in replacing damaged urinary system tissues, such as bladder mucosa, oral mucosa, and genital skin ( Jiang et al, 2018 ). However, its prominent limitations lie in the insufficient source of donor tissue, immune rejection, the essential difference of structure and function between the donor site and the transplantation site, as well as related various complications, including infection, stone formation, metabolic disorder, excessive mucus production, and so on ( Wang et al, 2021a ; Chen et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Research progress of biomaterials and innovative technologies in urinary tissue engineering

Duan

Wang

Fan

et al. 2023

Front. Bioeng. Biotechnol.

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Substantial interests have been attracted to multiple bioactive and biomimetic biomaterials in recent decades because of their ability in presenting a structural and functional reconstruction of urinary tissues. Some innovative technologies have also been surging in urinary tissue engineering and urological regeneration by providing insights into the physiological behavior of the urinary system. As such, the hierarchical structure and tissue function of the bladder, urethra, and ureter can be reproduced similarly to the native urinary tissues. This review aims to summarize recent advances in functional biomaterials and biomimetic technologies toward urological reconstruction. Various nanofirous biomaterials derived from decellularized natural tissues, synthetic biopolymers, and hybrid scaffolds were developed with desired microstructure, surface chemistry, and mechanical properties. Some growth factors, drugs, as well as inorganic nanomaterials were also utilized to enhance the biological activity and functionality of scaffolds. Notably, it is emphasized that advanced approaches, such as 3D (bio) printing and organoids, have also been developed to facilitate structural and functional regeneration of the urological system. So in this review, we discussed the fabrication strategies, physiochemical properties, and biofunctional modification of regenerative biomaterials and their potential clinical application of fast-evolving technologies. In addition, future prospective and commercial products are further proposed and discussed.

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Section: Introductionmentioning

confidence: 99%

Research progress of biomaterials and innovative technologies in urinary tissue engineering

Duan

Wang

Fan

et al. 2023

Front. Bioeng. Biotechnol.

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Study on Protein Nanomarker Combined with Vascular Endothelial Growth Factor to Improve Vascularization of Rabbit Urethral Defect Tissue Engineering

Yang¹,

Liu

Ying

2022

j biomater tissue eng

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To construct the tissue engineering urethral material that is closest to the normal urethral structure in the true sense in vitro. Abdominal ADSC from a 2-month-old New Zealand white rabbit was extracted and directly compounded with non-woven polyglycolic acid (PGA) (control group) to induce the differentiation of myoblasts and epithelial-like cells in vitro and shaped into urethral structure lumen Observation group); After Gd chelating protein nano-labeling and VEGF-loaded sustained release, the rabbit model of a long urethral defect was replanted and cultured for 4 weeks, 8 weeks and 12 weeks, respectively. There was no difference in urinary tract patency rate, urinary tract infection, and renal dysfunction rate between the two groups (P > 0.05). The urine flow rate in the observation group was significantly higher than that in the control group, and the residual volume decreased (P < 0.05). The blood vessel density and CD31 percentage in the observation group increased (P < 0.05). Compared with the conventional ADSC directly in contact with the composite material to construct the urethra, in vitro induction of ADSC to myoblasts and epithelial-like cells respectively, and then use the cell membrane technology to build a tissue engineering urethral material that is closest to the normal urethral structure in the true sense, and loaded with VEGF Loop release technology can significantly improve urodynamic functions, optimize tissue engineering urethral structure and vascularization, and is expected to become a new technology for constructing new tissue engineering urethral materials.

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Autologous granulation tissue tubes for replacement of urethral defects: An experimental study in male rabbits

Cited by 2 publications

References 21 publications

Research progress of biomaterials and innovative technologies in urinary tissue engineering

Research progress of biomaterials and innovative technologies in urinary tissue engineering

Study on Protein Nanomarker Combined with Vascular Endothelial Growth Factor to Improve Vascularization of Rabbit Urethral Defect Tissue Engineering

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