Autologous serum eye drops for ocular surface disorders

Geerling, Gerd; MacLennan, Sarah; Hartwig, D.

doi:10.1136/bjo.2004.044347

Cited by 376 publications

(376 citation statements)

References 43 publications

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“…Pharmaceutical lubricants offer little to no nutrition. While autologous serum eye drops have tear-like biochemical characteristics and supply nutritional components, 9 allogeneic serum can be used as an alternative in certain situations. In our study, the PED healed within 2 weeks in 41.7% (15/36) of the patients, within 4 weeks in 63.9% (23/36), and within 2 months in 72.2% (26/36).…”

Section: Discussionmentioning

confidence: 99%

Allogeneic serum eye drops for the treatment of persistent corneal epithelial defect

et al. 2008

Eye

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Section: Discussionmentioning

confidence: 99%

Allogeneic serum eye drops for the treatment of persistent corneal epithelial defect

et al. 2008

Eye

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“…[21] Research conducted by Ilham (2011) using rats that were divided into 5 groups which received treatment using autologous serum eye drops with various concentrations showed that the autologous serum has an antibacterial effect because it contains some antibacterial agents including immunoglobulins, lysozyme, and complement which caused lysis of the bacteria and provide bacteriostatic effect, whereas the anti-inflammatory effects of the autologous serum were based on the epiteliotrophic factors (epidermal growth factor, transforming growth factor B, fibronectin, and vitamin A) and neutrophilic (substance P, nerve growth factor) contained in the serum. [20,22,23] In this study, preovulation estradiol levels were higher than estradiol levels during menstruation or during the luteal phase. Based on statistic test, the p value was < 0.05.…”

Section: Discussionmentioning

confidence: 85%

“…Estradiol is the primary active estrogen. [20] At preovulation phase, estradiol levels in blood will increase. Estradiol level during preovulation phase were higher than in menstrual and luteal phase.…”

Section: Discussionmentioning

confidence: 99%

Effectivity of Preovulation Phase Autologous Serum Application on Moderate-Severe Acne Vulgaris Patients

Edison¹,

Amin²,

Djawad³

et al. 2016

AJCEM

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Acne vulgaris (AV) is the most common skin disease, including in Indonesia. This research aims to determine the effectivity of preovulation phase autologous serum application in patients with moderate-severe AV. This research was conducted in Makassar, South Sulawesi. Thirteen patient samples with moderate-severe AV who have met the inclusion criteria were taken from Dr. Wahidin Sudirohusodo General Hospital, Public Senior High School, and Medical Faculty of Hasanuddin University Laboratory. The method used is clinical trial. The examination was done by observing the clinical manifestations, sebum level using 815 sebumeter, and estradiol level examination. All patiens were given the same autologous serum treatment which is applied once a day every night and followed-up on day 21 and day 42. The data were processed using paired t test and Fisher's exact test. The result showed that there were improvements in clinical manifestation and decreased sebum level after autologous serum application (p < 0.05) on day 21 compared to day 1, on day 42 compared to day 21, and day 42 compared to day 1. Preovulation estradiol level were higher than the estradiol level on menstruation or in lutheal phase (p < 0.05). There were no significant relationship between routine activity, familial history, peanuts, chocolate, spicy and oily food consumption, wearing cosmetics, stress, and squeezing pimples (trauma) with number of acne lesion and sebum level (p < 0.05).

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“…immunoglobulin G and immunoglobulin A) and lysozyme. 8,32 Apoptosis is a distinct form of cell death controlled by an internally encoded suicide programme that includes independent extrinsic and intrinsic pathways. Amikacin, which is not metabolised and remains in hair cells for months, causes the formation of reactive oxygen species, leading to apoptosis.…”

Section: Discussionmentioning

confidence: 99%

Therapeutic and protective effects of autologous serum in amikacin-induced ototoxicity

et al. 2017

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Objective: Possible therapeutic and protective benefits of intratympanic autologous serum application in amikacininduced ototoxicity were investigated.Methods: Twenty-four guinea pigs were separated equally into two groups: therapeutic (group A) and protective (group B). Transient evoked otoacoustic emissions were recorded before and after autologous serum application. Apoptotic cells were identified in the organ of Corti, spiral limbus and spiral ganglion by the terminal deoxynucleotidyl transferase-mediated dUTP nick-end labelling ('TUNEL') method.Results: Transient evoked otoacoustic emission responses at 1, 1.4 and 2.8 kHz improved without significance after autologous serum application in group A ( p > 0.05). A significantly protective effect of autologous serum was determined at 4 kHz in group B ( p < 0.05). There were significantly fewer apoptotic cells at the spiral limbus in the therapeutic and protective groups compared to the control group ( p < 0.05).Conclusion: Autologous serum may offer protection against ototoxicity-induced hearing loss, but it cannot restore hearing. Immunohistochemically, autologous serum significantly decreases activation of the intrinsic pathway of pro-apoptotic signalling in mesenchymal cells compared to neurons and neurosensory cells.

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Autologous serum eye drops for ocular surface disorders

Cited by 376 publications

References 43 publications

Allogeneic serum eye drops for the treatment of persistent corneal epithelial defect

Allogeneic serum eye drops for the treatment of persistent corneal epithelial defect

Effectivity of Preovulation Phase Autologous Serum Application on Moderate-Severe Acne Vulgaris Patients

Therapeutic and protective effects of autologous serum in amikacin-induced ototoxicity

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