Autologous stem cells therapy, The first baby of idiopathic premature ovarian failure

Edessy, Mahmoud; Hosni, Hasnaa A.; Shady, Yousef A. Abu; Waf, Y.; Bakr, Samiha M. Abou; Kamel, Mohamed

doi:10.5530/ami.2016.1.7

Cited by 85 publications

(65 citation statements)

References 10 publications

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“…Along with the classical postulate, the wor sening of cancer prognosis with the use of stimulants and during pregnancy, there are the data on the ability of stem cells to suppress tumor growth independently and as a "vector" [11][12][13][14] as well as about the dif ferentiated approaches to the restoration of fertility in the women who underwent oncology [15,16]. Most researchers use the introduction of various stem cells, often of either placental or adipose origin directly into the ovary, to restore the function of the ovaries that is effective in improving sexual function and ferti lity [17][18][19][20], but requires surgery, affects less other organs, demands the use of nonstandardized culture techniques.…”

mentioning

confidence: 99%

Comparison of Various Tissue and Cell Therapy Approaches When Restoring Ovarian, Hepatic and Kidney’s Function After Chemotherapy-Induced Ovarian Failure

Kozub¹,

Prokopіuk²,

Skibina³

et al. 2017

Exp. Onc.

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About 1% of women suffer from premature ovarian failure, which leads to a significant deterioration in the life quality. Most often this condition is caused by performed chemotherapy, autoimmune diseases, surgery performed on ovaries, uterus, or fallopian tubes. The aim of this study was to compare different approaches of tissue and cell therapy in restoring the sexual function in case of ovarian failure induced by chemotherapy. Materials and Methods: The study was carried out in BALB/c mice with the modeled ovarian failure, induced by cyclophosphamide and busulfan. The restoration dynamics of ovarian and sexual function, liver and kidneys after application of cryopreserved explants, cryoextract, placental mesenchymal stem cells, those of adipose tissue has been studied. Results: It has been shown that the use of various methods of cell and tissue therapy has comparable efficacy when treating an ovarian failure induced by chemotherapy. The most rapid and complete restoration of the reproductive system, liver and kidneys was observed when using the placental explants, extract and cells, but not with the use of mesenchymal stem cells of adipose tissue. No recovery of fertility in this experiment was observed. Conclusion: Various methods of cellular and tissue therapy are perspective in treatment of the chemotherapy complications. More effective are placental derivates.

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confidence: 99%

Comparison of Various Tissue and Cell Therapy Approaches When Restoring Ovarian, Hepatic and Kidney’s Function After Chemotherapy-Induced Ovarian Failure

Kozub¹,

Prokopіuk²,

Skibina³

et al. 2017

Exp. Onc.

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“…Several groups have observed similar success and live births in mice on transplanting mesenchymal cells in both non-functional testis and ovary (24). A human baby has been born by transplanting autologus mesenchymal cells in a POF ovary (25).…”

Section: Commentarymentioning

confidence: 81%

Making gametes from pluripotent stem cells: embryonic stem cells or very small embryonic-like stem cells?

Bhartiya¹,

Anand²,

Patel³

2016

Stem Cell Investig.

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“…172 With regard to humans, one team investigated transplantation of BMSCs into ovaries of 10 women diagnosed with premature ovarian failure and reported recovery of menstruation in two cases and one pregnancy with delivery of a healthy baby. 173 Even if promising, these results should be further confirmed and viewed with caution, since risks of transformation and tumorigenicity in MSC-based therapies are still debatable. 174…”

Section: Current Evidence Of Scs In the Ovarymentioning

confidence: 99%

<p>Role of stem cells in fertility preservation: current insights</p>

Vermeulen¹,

Giudice²,

Vento³

et al. 2019

SCCAA

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While improvements made in the field of cancer therapy allow high survival rates, gonadotoxicity of chemo- and radiotherapy can lead to infertility in male and female pre- and postpubertal patients. Clinical options to preserve fertility before starting gonadotoxic therapies by cryopreserving sperm or oocytes for future use with assisted reproductive technology (ART) are now applied worldwide. Cryopreservation of pre- and postpubertal ovarian tissue containing primordial follicles, though still considered experimental, has already led to the birth of healthy babies after autotransplantation and is performed in an increasing number of centers. For prepubertal boys who do not produce gametes ready for fertilization, cryopreservation of immature testicular tissue (ITT) containing spermatogonial stem cells may be proposed as an experimental strategy with the aim of restoring fertility. Based on achievements in nonhuman primates, autotransplantation of ITT or testicular cell suspensions appears promising to restore fertility of young cancer survivors. So far, whether in two- or three-dimensional culture systems, in vitro maturation of immature male and female gonadal cells or tissue has not demonstrated a capacity to produce safe gametes for ART. Recently, primordial germ cells have been generated from embryonic and induced pluripotent stem cells, but further investigations regarding efficiency and safety are needed. Transplantation of mesenchymal stem cells to improve the vascularization of gonadal tissue grafts, increase the colonization of transplanted cells, and restore the damaged somatic compartment could overcome the current limitations encountered with transplantation.

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Autologous stem cells therapy, The first baby of idiopathic premature ovarian failure

Cited by 85 publications

References 10 publications

Comparison of Various Tissue and Cell Therapy Approaches When Restoring Ovarian, Hepatic and Kidney’s Function After Chemotherapy-Induced Ovarian Failure

Comparison of Various Tissue and Cell Therapy Approaches When Restoring Ovarian, Hepatic and Kidney’s Function After Chemotherapy-Induced Ovarian Failure

Making gametes from pluripotent stem cells: embryonic stem cells or very small embryonic-like stem cells?

<p>Role of stem cells in fertility preservation: current insights</p>

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